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55 results for “hip dysplasia”
Developmental Dysplasia of the Hip: Observation vs. Bracing
ClinicalTrials.gov study NCT05869851. IPD Sharing: NO. Countries: 1. Publications: 1.
Biomechanical Reconstruction of Three Different Hip Stem Designs in Hip Dysplasia Using a 3D CT-based Planning Software
ClinicalTrials.gov study NCT04904640. IPD Sharing: NO. Countries: 1. Publications: 4.
Computed tomography reveals hip dysplasia in the extinct Pleistocene saber-tooth cat Smilodon
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UK dogs data from: Genome-wide association studies for canine hip dysplasia in single and multiple populations – implications and potential novel risk loci
<p>Background: <span>Association mapping studies of quantitative trait loci (QTL) for canine hip dysplasia (CHD) </span><span>can contribute to the understanding of the genetic background of this common and debilitating disease and might contribute to its genetic improvement. The power of association studies for CHD is limited by relatively small sample numbers for CHD records within countries, suggesting potential benefits of joining data across countries. However, this is complicated due to the use of different scoring systems across countries. In this study, we incorporated routinely assessed CHD records and genotype data of German Shepherd dogs from </span><span><span>two</span></span><span> countries </span><span><span>(UK and Sweden)</span></span><span> to perform </span><span>genome-wide association stud</span><span>ies (GWAS) within populations using different variations of CHD phenotypes. As phenotypes, dogs were either classified into cases and controls based on the </span><i><span>Fédération Cynologique Internationale</span></i><span> (FCI) five-level grading of the worst hip or the FCI grade was treated as an ordinal trait. </span><span><span>In a subsequent meta-analysis, we added publicly available data from a Finnish population and performed the GWAS across all populations.</span></span><span> Genetic associations for the CHD phenotypes were evaluated in a linear mixed model using 62,089 SNPs.</span></p> <p>Results: <span><span>Multiple SNPs with genome-wide significant and suggestive</span></span><span><span> associations</span></span><span> </span><span><span>were detected in single-population GWAS and the meta-analysis.</span></span><span> Few of these SNPs overlapped between populations </span><span><span>or between single-population GWAS and the meta-analysis</span></span><span>, suggesting that many CHD-related QTL are population-specific. More significant or suggestive SNPs were identified when FCI grades were used as phenotypes in comparison to the case-control approach. </span><i><span>MED13</span></i><span> (Chr 9) and </span><i><span>PLEKHA7</span></i><span> (Chr 21) emerged as novel positional candidate genes associated with hip dysplasia.</span></p> <p>Conclusions: <span>Our findings confirm the complex genetic nature of hip dysplasia in dogs, with multiple loci associated with the trait, </span><span><span>most</span></span><span> of which are population-specific. Routinely assessed CHD information collected across countries provide an opportunity to increase sample sizes and statistical power for association studies. While the lack of standardisation of CHD assessment schemes across countries poses a challenge, we showed that conversion of traits can be utilised to overcome this obstacle.</span></p>
Comparison Between Two Techniques of Capsulotomy During Capsulorrhaphy in Cases of Developmental Dysplasia of the Hip
ClinicalTrials.gov study NCT06439147. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
In Patients With Hip Dysplasia, Mid-Term Lower Extremities and Spine After Hip Arthroplasty Natural Course
ClinicalTrials.gov study NCT06176612. IPD Sharing: NO. Countries: 1. Publications: 3.
Modified Hip Capsular Incision: an Easier Way to do Hip Capsulorrhaphy in Developmental Dysplasia of the Hip (DDH)
ClinicalTrials.gov study NCT05717829. IPD Sharing: NO. Countries: 1. Publications: 4.
Movement Pattern in Patients With Hip Dysplasia
ClinicalTrials.gov study NCT01344421. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Ultrasound Screening for Developmental Dysplasia of the Hip in Newborns
ClinicalTrials.gov study NCT01818934. IPD Sharing: Not stated. Countries: 1. Publications: 7.
Pavlik Harness Treatment vs Monitoring for Treatment of Developmental Dysplasia of the Hip (DDH) in Babies Diagnosed With Graf Type 2 Hips
ClinicalTrials.gov study NCT07111858. IPD Sharing: NO. Countries: 1. Publications: 1.
Efficacy and Satisfaction Comparing Two Braces in the Treatment of Developmental Dysplasia of the Hip (DDH) in Infants
ClinicalTrials.gov study NCT01375218. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Early Abduction Splintage on Stable Hips in Infants With Developmental Dysplasia of the Hip
ClinicalTrials.gov study NCT02885831. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Physical Capacity Among Patients Treated With Periacetabular Osteotomy for Hip Dysplasia: a Cross-sectional Study
ClinicalTrials.gov study NCT04591067. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Mid-term Functional Comparisons of Unilateral and Bilateral Developmental Dysplasia of the Hip
ClinicalTrials.gov study NCT05853510. IPD Sharing: NO. Countries: 1. Publications: 0.
Truncal Blocks for Pediatric With Developmental Dysplasia of the Hip Undergoing Open Reduction
ClinicalTrials.gov study NCT03189966. IPD Sharing: NO. Countries: 1. Publications: 27.
Exercise and Patient Education Compared With Usual Care in Patients With Hip Dysplasia
ClinicalTrials.gov study NCT04795843. IPD Sharing: YES. Countries: 1. Publications: 3.
Evaluation of Aid to Diagnosis for Congenital Dysplasia of the Hip in General Practice
ClinicalTrials.gov study NCT04101903. IPD Sharing: YES. Countries: 1. Publications: 1.
UK dogs data from: Genome-wide association studies for canine hip dysplasia in single and multiple populations – implications and potential novel risk loci
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Using Artificial Intelligence to Screen for Hip Dysplasia
ClinicalTrials.gov study NCT06647225. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Ligamentum Teres in Management of Developmental Hip Dysplasia
ClinicalTrials.gov study NCT07356921. IPD Sharing: Not stated. Countries: 0. Publications: 2.
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