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ShareScore release 0.9.0
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32 results for “host-microbe”
Temperature perturbation of cellular host-microbe interactions explains continent-wide endosymbiont prevalence
<p>Endosymbioses influence host physiology, reproduction, and fitness, but these relationships require efficient microbe transmission between host generations to persist. Maternally transmitted <i>Wolbachia</i> are the most common known endosymbionts, but their frequencies vary widely within and among host populations for unknown reasons. Here we integrate genomic, cellular, and phenotypic analyses with mathematical models to provide an unexpectedly simple explanation for global <i>w</i>Mel <i>Wolbachia</i> prevalence in <i>Drosophila melanogaster</i>. Cooling temperatures decrease <i>w</i>Mel cellular abundance at a key stage of host oogenesis, producing temperature-dependent variation in maternal transmission that plausibly explains latitudinal clines of <i>w</i>Mel frequencies on multiple continents. <i>w</i>Mel sampled from a temperate climate targets the germline more efficiently in the cold than a recently differentiated tropical variant (~2,200 years ago), indicative of rapid <i>w</i>Mel adaptation to climate. Genomic analyses identify a very narrow list of <i>w</i>Mel alleles—most notably, a derived stop codon in the major <i>Wolbachia</i> surface protein WspB—that underlie thermal sensitivity of cellular<i>Wolbachia</i> abundance and covary with temperature globally. Decoupling temperate <i>w</i>Mel and host genomes further reduces transmission in the cold, a pattern that is characteristic of host-microbe co-adaptation to a temperate climate. Complex interactions among <i>Wolbachia</i>, hosts, and the environment (GxGxE) mediate <i>w</i>Mel cellular abundance and maternal transmission, implicating temperature as a key determinant of <i>Wolbachia</i> spread and equilibrium frequencies, in conjunction with <i>Wolbachia</i> effects on host fitness and reproduction. Our results motivate strategic use of locally selected <i>w</i>Mel variants for <i>Wolbachia</i>-based biocontrol efforts, which currently protect millions of individuals from arboviruses that cause human disease.</p>
Temperature perturbation of cellular host-microbe interactions explains continent-wide endosymbiont prevalence
Open the record for dataset details and reuse information.
Integrating Metagenomic and Metabolomic Insights into Host-Microbe Connections for Gut-Lung Axis in Childhood Asthma
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Bern Human Organoid-Study to Study Host-microbe Interaction
ClinicalTrials.gov study NCT05323357. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Multi-Center Protocol for Obtaining and Storing Human Samples for Immediate or Future Microbial, Immune, or Host-Microbe Scientific Study
ClinicalTrials.gov study NCT00764023. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Transmission efficiency drives host-microbe associations
<p>MatLab code to accompany "Transmission efficiency drives host-microbe associations" Modelling is divided into three files - Asexual hosts, Male mate choice and Female mate choice. </p>
Data from: The microbiota of diapause: how host-microbe associations are formed after dormancy in an aquatic crustacean
1. A critical question in symbiosis research is where and how organisms obtain beneficial microbial symbionts in different ecological contexts. Microbiota of juveniles are often derived directly from their mother or from the immediate environment. The origin of beneficial symbionts, however, is less obvious in organisms with diapause and dispersal stages, such as plants with dormant seeds and animals in ephemeral or strongly seasonal habitats. In these cases, parents and offspring are separated in time and space, which may affect opportunities for both vertical and horizontal transmission of symbionts. 2. The planktonic crustacean Daphnia produces long-lasting resting eggs to endure winter freezing and summer droughts and requires microbiota for growth and reproduction. It is unknown how hatchlings from resting stages form associations with microbial consorts after diapause. 3. Using natural samples of D. magna resting eggs after several years of storage, we show that the total bacterial community derived from both the exterior and interior of the eggs' ephippial cases is sufficiently beneficial to ensure normal Daphnia functioning in otherwise bacteria-free conditions. We do not find direct evidence that the required bacteria are of maternal origin, though sequencing reveals that the resting stage is accompanied by bacterial taxa previously found in association with adult animals. 4. These findings suggest that while Daphnia are strongly dependent on environmental bacteria for normal functioning, host-bacteria associations are somewhat general and availability of specific bacteria is not a strong constraint on host ecology. Nevertheless, animals and microbes may be ecologically linked through co-dispersal.
Effect of Dupilumab (Anti-IL4Rα) on the Host-Microbe Interface in Atopic Dermatitis
ClinicalTrials.gov study NCT03389893. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Plasma Host-Microbe Proteomics to Predict Complications in High-risk Febrile Neutropenia
ClinicalTrials.gov study NCT07277387. IPD Sharing: YES. Countries: 1. Publications: 0.
Data from: The microbiota of diapause: how host-microbe associations are formed after dormancy in an aquatic crustacean
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Impact of radiation dose and time since radiation exposure on host-microbe relationship
GEO Series GSE244571. Mus musculus. 38 samples. Type: Other.
An Anaerobic In Vitro Flow Model for Studying Interactions at the Gastrointestinal Host-Microbe Interface
GEO Series GSE284670. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
The effects of host-microbe interactions on the epigenetic signatures of cervicovaginal epithelial cells [ATAC-Seq]
GEO Series GSE233444. Homo sapiens. 18 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Mutual reinforcement of pathophysiological host-microbe interactions that maintain steady state conditions of disease
GEO Series GSE59320. Mus musculus. 16 samples. Type: Expression profiling by array.
The effects of host-microbe interactions on cervicovaginal epithelial cells
GEO Series GSE234837. Homo sapiens. 81 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Host-Microbe Interactions in the Nasal Cavity of Dogs with Chronic Idiopathic Rhinitis
GEO Series GSE255529. Canis lupus familiaris. 12 samples. Type: Expression profiling by high throughput sequencing.
The effects of host-microbe interactions on the transcriptomic signatures of cervicovaginal epithelial cells [RNA-seq]
GEO Series GSE234836. Homo sapiens. 63 samples. Type: Expression profiling by high throughput sequencing.
Therapeutic Delivery of CCL2 Modulates Immune Response and Restores Host-microbe Homeostasis
GEO Series GSE274721. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing; Other.
Trans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell glycosylation
GEO Series GSE224516. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Integrated host-microbe metagenomics of cell-free nucleic acid for sepsis diagnosis in critically ill adults [paxgene]
GEO Series GSE189400. Homo sapiens. 221 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.