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Dataset results
18 results for “host-microbe interactions”
Temperature perturbation of cellular host-microbe interactions explains continent-wide endosymbiont prevalence
<p>Endosymbioses influence host physiology, reproduction, and fitness, but these relationships require efficient microbe transmission between host generations to persist. Maternally transmitted <i>Wolbachia</i> are the most common known endosymbionts, but their frequencies vary widely within and among host populations for unknown reasons. Here we integrate genomic, cellular, and phenotypic analyses with mathematical models to provide an unexpectedly simple explanation for global <i>w</i>Mel <i>Wolbachia</i> prevalence in <i>Drosophila melanogaster</i>. Cooling temperatures decrease <i>w</i>Mel cellular abundance at a key stage of host oogenesis, producing temperature-dependent variation in maternal transmission that plausibly explains latitudinal clines of <i>w</i>Mel frequencies on multiple continents. <i>w</i>Mel sampled from a temperate climate targets the germline more efficiently in the cold than a recently differentiated tropical variant (~2,200 years ago), indicative of rapid <i>w</i>Mel adaptation to climate. Genomic analyses identify a very narrow list of <i>w</i>Mel alleles—most notably, a derived stop codon in the major <i>Wolbachia</i> surface protein WspB—that underlie thermal sensitivity of cellular<i>Wolbachia</i> abundance and covary with temperature globally. Decoupling temperate <i>w</i>Mel and host genomes further reduces transmission in the cold, a pattern that is characteristic of host-microbe co-adaptation to a temperate climate. Complex interactions among <i>Wolbachia</i>, hosts, and the environment (GxGxE) mediate <i>w</i>Mel cellular abundance and maternal transmission, implicating temperature as a key determinant of <i>Wolbachia</i> spread and equilibrium frequencies, in conjunction with <i>Wolbachia</i> effects on host fitness and reproduction. Our results motivate strategic use of locally selected <i>w</i>Mel variants for <i>Wolbachia</i>-based biocontrol efforts, which currently protect millions of individuals from arboviruses that cause human disease.</p>
Temperature perturbation of cellular host-microbe interactions explains continent-wide endosymbiont prevalence
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Bern Human Organoid-Study to Study Host-microbe Interaction
ClinicalTrials.gov study NCT05323357. IPD Sharing: Not stated. Countries: 1. Publications: 1.
An Anaerobic In Vitro Flow Model for Studying Interactions at the Gastrointestinal Host-Microbe Interface
GEO Series GSE284670. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
The effects of host-microbe interactions on the epigenetic signatures of cervicovaginal epithelial cells [ATAC-Seq]
GEO Series GSE233444. Homo sapiens. 18 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Mutual reinforcement of pathophysiological host-microbe interactions that maintain steady state conditions of disease
GEO Series GSE59320. Mus musculus. 16 samples. Type: Expression profiling by array.
The effects of host-microbe interactions on cervicovaginal epithelial cells
GEO Series GSE234837. Homo sapiens. 81 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Host-Microbe Interactions in the Nasal Cavity of Dogs with Chronic Idiopathic Rhinitis
GEO Series GSE255529. Canis lupus familiaris. 12 samples. Type: Expression profiling by high throughput sequencing.
The effects of host-microbe interactions on the transcriptomic signatures of cervicovaginal epithelial cells [RNA-seq]
GEO Series GSE234836. Homo sapiens. 63 samples. Type: Expression profiling by high throughput sequencing.
Trans-Golgi protein TVP23B regulates host-microbe interactions via Paneth cell homeostasis and Goblet cell glycosylation
GEO Series GSE224516. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
The microbiome buffers tadpole hosts from heat stress: a hologenomic approach to understand host-microbe interactions under warming
GEO Series GSE208645. Lithobates clamitans. 20 samples. Type: Expression profiling by high throughput sequencing.
Host-Microbe Interactions in Biliary Dilatation
ClinicalTrials.gov study NCT07152496. IPD Sharing: NO. Countries: 1. Publications: 0.
Host-microbe interactions and changes during intestinal epithelial cell death-dependent dysbiosis
GEO Series GSE244920. Escherichia coli. 24 samples. Type: Expression profiling by high throughput sequencing.
Host-microbe interactions following L. plantarum administration in SIV-infected and uninfected rhesus macaques
GEO Series GSE139271. Macaca mulatta. 12 samples. Type: Expression profiling by array.
Microbially competent 3D skin - a novel test system for studying host-microbe interaction
GEO Series GSE129864. Homo sapiens. 9 samples. Type: Expression profiling by array.
Hydra modifies bacterial quorum sensing signals for stabilizing host-microbe interactions
GEO Series GSE81281. Curvibacter sp. AEP1.3. 15 samples. Type: Expression profiling by high throughput sequencing.
Spatial transcriptomics revealing host-microbe interactions
GEO Series GSE210738. mouse gut metagenome; Mus musculus. 10 samples. Type: Other.
The microbiome buffers tadpole hosts from the deleterious effects of heat stress: a hologenomic approach to understand host-microbe interactions under warming conditions.
GEO Series GSE208646. Lithobates clamitans. 20 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.