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13 results for “household transmission study”

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zenodo40/100

An epidemiological Study to Assess Household Transmission & Associated Risk Factors for COVID-19 Disease amongst Residents of Delhi, India.

<p><strong><em>Executive summary</em></strong>:&nbsp;Studying the spread and epidemiological characteristics of COVID-19 virus specially in household settings are needed to prepare our self-better in preventing and controlling this epidemic. In this study we proposed a conceptual framework of four level of determinates and tried to understand the transmission dynamics of COVID-19 among household contacts along with clinical, epidemiological and virologic&nbsp;characteristics of the infection.&nbsp;</p> <p><strong>Aims &amp; Objectives:</strong></p> <ol> <li>the proportion of asymptomatic cases and symptomatic cases;</li> <li>the incubation period of COVID-19 and the duration of infectiousness and of detectable shedding;</li> <li>the serial interval of COVID-19 infection;&nbsp;</li> <li>clinical risk factors for COVID-19, and the clinical course and severity of disease;&nbsp;</li> <li>high-risk population subgroups;</li> <li>the secondary infection rate and secondary clinical attack rate of COVID-19 infection among household contacts; and</li> <li>the associations of various factors across four dimensions interaction associated with risk of transmission</li> </ol> <p><strong>Methodology:</strong>&nbsp;This was a case-ascertained study where all susceptible contacts of a laboratory confirmed COVID-19 case were studied prospective for four weeks after their enrolment. It was&nbsp;done in New Delhi, during the end of first wave as well as whole second wave from December&nbsp;2020 to July 2021. The study team collected the key information by questionnaire along with blood and oro-nasal swab during the household visits. Follow-up was done on day 7, 14 and 28&nbsp;for observing the disease characteristic and symptomatology along with confirmation by serum&nbsp;and oro-nasal swab testing. Daily characteristics of the infection were noted by the participants on&nbsp;symptoms diary.</p> <p><strong>Results:&nbsp;</strong>We enrolled 99 households, each having one laboratory-confirmed COVID-19 index case along with their 318 susceptible contacts. By the end of the follow-up, secondary infection rate was seen at 55.5%, while seroconversion in 46.6%.&nbsp;&nbsp;Hospitalization and case fatality rate was 3.83% and 1.7% respectively. Among epidemiological characteristics we observed serial interval of 8.0 &plusmn; 6.7 days, generation time 3.8&nbsp;&nbsp;&plusmn; 6.4, while secondary attack rate was 54.9%. The predictors of secondary infection among individual contact level were being female (OR:2.13, 95% CI:1.27 - 3.57), age of the household contact (1.01;1.00 - 1.03), symptoms at baseline (3.39; 1.61- 7.12) and during follow-up (3.18; 1.64 - 6.19), while only symptoms during follow-up (3.81: 1.43 - 10.14) and being RT-PCR positive (8.32; 3.22 -21.54) was significantly and independently associated with seroconversion among household contacts. Among index case-level age of the primary case (1.03; 1.01 -1.04) and any symptoms during follow-up (6.29; 1.83-21.63) significantly and independently associated with secondary infection while any symptoms during follow-up was associated with seroconversion among household contacts. Among household-level characteristics having more rooms (4.44; 2.16 - 9.13) independently associated with secondary infection, while more rooms (3.98; 1.23 -12.90) along with overcrowding (0.37; 0.16 - 0.82) associated with seroconversion. Among contact pattern only taking care of the index case (2.02;1.21- 3.38) was significantly and independently associated with secondary infection, while none was associated with seroconversion.</p> <p><strong>Conclusion:&nbsp;</strong>A high secondary cases and&nbsp;secondary attack rate was seen in our study. This highlights the need to adopts strict measure and advocate COVID appropriate behaviours in order to break the transmission chain at household level. The&nbsp;targeted approach at household contacts with higher risk would be efficient in limiting the development of infection among susceptible contacts.&nbsp;</p>

opencc-by-4.0Nov 2021View details →
ClinicalTrials.gov36/100

Study to Assess the Efficacy of Baloxavir Marboxil Versus Placebo to Reduce Onward Transmission of Influenza A or B in Households

ClinicalTrials.gov study NCT03969212. IPD Sharing: YES. Countries: 16. Publications: 2.

controlledIPD-YESFeb 2026View details →
zenodo32/100

Transmission Dynamics of COVID-19 Disease among household contacts in Delhi, India (SARS CoV-2 HT Study)

<p>Results from households in the MAMC Delhi FFX Unity study&nbsp;</p>

opencc-by-4.0Feb 2022View details →
ClinicalTrials.gov32/100

Household Influenza Transmission Study

ClinicalTrials.gov study NCT01251679. IPD Sharing: Not stated. Countries: 1. Publications: 2.

restrictedIPD-UNDECIDEDFeb 2026View details →
dryad32/100

Data from: Transmission of multidrug-resistant and drug-susceptible tuberculosis within households: a prospective cohort study

Open the record for dataset details and reuse information.

publicJun 2016View details →
ClinicalTrials.gov28/100

Household Study of COVID-19, Influenza and RSV Burden, Transmission Dynamics and Viral Interaction in South Africa

ClinicalTrials.gov study NCT05277298. IPD Sharing: YES. Countries: 1. Publications: 0.

controlledIPD-YESFeb 2026View details →
ClinicalTrials.gov28/100

COVID-19 Household Transmission Study

ClinicalTrials.gov study NCT04445233. IPD Sharing: YES. Countries: 1. Publications: 0.

controlledIPD-YESFeb 2026View details →
ClinicalTrials.gov24/100

Transmission of Respiratory Viruses in Households in The Gambia: a Longitudinal Cohort Study (TransVIR)

ClinicalTrials.gov study NCT05952336. IPD Sharing: NO. Countries: 1. Publications: 0.

closedIPD-NOFeb 2026View details →
ClinicalTrials.gov24/100

Household Transmission Investigation Study for COVID-19 in Tropical Regions

ClinicalTrials.gov study NCT04328129. IPD Sharing: NO. Countries: 3. Publications: 0.

closedIPD-NOFeb 2026View details →
ClinicalTrials.gov24/100

A Surveillance Study of Susceptibility to Baloxavir Marboxil in Pediatric Participants With Influenza and Transmission of Influenza to Household Contacts

ClinicalTrials.gov study NCT06094010. IPD Sharing: YES. Countries: 4. Publications: 0.

controlledIPD-YESFeb 2026View details →
ClinicalTrials.gov20/100

A Study to Investigate the Transmission and Burden of PVL-MRSA in Households in Sri Lanka

ClinicalTrials.gov study NCT04884958. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.

restrictedIPD-UNDECIDEDFeb 2026View details →
ClinicalTrials.gov20/100

A Prospective Household Observational Cohort Study of Influenza, Respiratory Syncytial Virus and Other Respiratory Pathogens Community Burden and Transmission Dynamics in South Africa

ClinicalTrials.gov study NCT02519803. IPD Sharing: Not stated. Countries: 0. Publications: 0.

restrictedIPD-UNDECIDEDFeb 2026View details →
zenodo16/100

A Prospective Study on the Transmission dynamics of Corona virus disease (2019) (COVID-19) among Household contacts in Delhi, India. (SARS CoV-2 HT Study)

<p>This is raw data set for the research on transmission dynamics of COVID-19 among households in Delhi, India.</p>

restrictedNov 2022View details →

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