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125 results for “human cytomegalovirus”
Correlative 3D SBFSEM data from: Intermittent bulk release of human cytomegalovirus
<p>Human Cytomegalovirus (HCMV) can infect a variety of cell types by using virions of varying glycoprotein compositions. It is still unclear how this diversity is generated, but spatio-temporally separated envelopment and egress pathways might play a role. So far, one egress pathway has been described in which HCMV particles are individually enveloped into small vesicles and are subsequently exocytosed continuously. However, some studies have also found enveloped virus particles inside multivesicular structures but could not link them to productive egress or degradation pathways.<br>We used a novel 3D-CLEM workflow allowing us to investigate these structures in HCMV morphogenesis and egress at high spatio-temporal resolution. We found that multiple envelopment events occurred at individual vesicles leading to multiviral bodies (MViBs), which subsequently traversed the cytoplasm to release virions as intermittent bulk pulses at the plasma membrane to form extracellular virus accumulations (EVAs). Our data support the existence of a novel bona fide HCMV egress pathway, which opens the gate to evaluate divergent egress pathways in generating virion diversity.</p>
Correlative 3D SBFSEM data from: Intermittent bulk release of human cytomegalovirus
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Intermittent bulk release of human cytomegalovirus: associated data
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Direct nanopore sequencing of human cytomegalovirus ge-nomes from high-titre clinical samples
<p>This archive contains the nanopore generated HCMV genomes from the urine and lung clinical samples. The illumina derived genome sequences have been uploaded to GenBank as they are of higher quality, the nanopore sequences are uploaded here to avoid duplication on GenBank. Raw FASTQ reads from the virus are uploaded to NCBI SRA. The full paper abstract is given below. Nanopore sequencing is becoming increasingly commonplace in clinical settings, particularly for diagnostics and outbreak investigations. Its portability, low cost and ability to operate in near real-time has propelled it to the forefront of the recent SARS-CoV-2 pandemic. Although high sequencing error rates initially hampered its wider implementation, improvements have continually been made with each iteration of the nanopore flow cells and base calling software. Here, we assess the feasibility of using nanopore sequencing to determine the complete genome of human cytomegalovirus (HCMV) present in high-titre clinical samples without viral DNA enrichment, PCR amplification or prior knowledge of the sequences. We utilised a hybrid bioinformatic approach that involved assembling the reads<em> de novo</em>, improving the <em>de novo</em> consensus through alignment of reads to the best-matching genome from a collated set of published genomes, and polishing the improved consensus. The final consensus genome sequences from a urine and a lung sample, the latter with an HCMV to human DNA load approximately 50 times lower than the former, achieved 99.97 and 99.93% identity, respectively, to the bench-mark consensuses obtained independently by Illumina sequencing. Thus, we demonstrate that nanopore sequencing is capable of determining HCMV genomes directly from high-titre clinical samples with high accuracy. </p>
Safety and Immunogenicity of the Human Cytomegalovirus (CMV) Vaccine (V160) in Healthy Japanese Men (V160-003)
ClinicalTrials.gov study NCT03840174. IPD Sharing: YES. Countries: 1. Publications: 1.
MK-8228 (Letermovir) in the Prevention of Human Cytomegalovirus (CMV) Infection and Disease in Adult Japanese Kidney Transplant Recipients (MK-8228-042)
ClinicalTrials.gov study NCT04129398. IPD Sharing: YES. Countries: 1. Publications: 1.
Letermovir Versus Valganciclovir to Prevent Human Cytomegalovirus Disease in Kidney Transplant Recipients (MK-8228-002)
ClinicalTrials.gov study NCT03443869. IPD Sharing: YES. Countries: 16. Publications: 3.
Study to Evaluate Safety, Tolerability, and Immunogenicity of Candidate Human Cytomegalovirus Vaccine in Healthy Adults
ClinicalTrials.gov study NCT02826798. IPD Sharing: NO. Countries: 1. Publications: 19.
Data from: Cryoelectron tomography of enveloped human cytomegalovirus particles
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Supplementary Materials for Discovery of Hub Genes and Construction of Competitive Endogenous RNA Network in Human Cytomegalovirus Infection Using Computational and Bioinformatics Tools
<p><span>Table S1: List of targeted genes by 41 differentially expressed microRNAs (DEMs) agreed in Targetscan and miRDB; Table S2: Significant biological process (BP) of 144 genes associated with Human Cytomegalovirus (HCMV); Table S3: Significant cellular components (CC) of 144 genes associated with HCMV; Table S4: Enriched molecular function (MF) of 144 genes associated with HCMV; Table S5: Pathways significantly affected by 144 genes in HCMV; Figure S1: Number of interactions for each gene in protein-protein interaction (PPI) network.</span></p>
Fig. 7 in Unusual matrine-adenine hybrids isolated from Sophora davidii and their inhibitory effects on human cytomegalovirus
Fig. 7. Molecular docking model of 1 (A), 2 (B), 3 (C), and 4 (D) bound to the HCMV protease (PDB: 2WPO). Hydrogen bond interactions are depicted with red dashes, while π–π and π–cation stacking interactions are displayed with green and yellow dashes, respectively. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)
A Study to Evaluate the Anti-inflammatory Effects of Letermovir (Prevymis) in Adults With Human Immunodeficiency Virus (HIV)-1 and Asymptomatic Cytomegalovirus (CMV) Who Are on Suppressive Antiretrovi
ClinicalTrials.gov study NCT04840199. IPD Sharing: YES. Countries: 1. Publications: 0.
Epidemiology of Human Cytomegalovirus Excretion in the Saliva of Children Attending Nursery in France
ClinicalTrials.gov study NCT01704222. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy Study of Human Cytomegalovirus (HCMV) Hyperimmune Globulin to Prevent Congenital HCMV Infection
ClinicalTrials.gov study NCT00881517. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Prospective, Randomized Study for Predicting Human Cytomegalovirus (hCMV) Infection Based on Baseline hCMV Specific T-cell Response in Kidney Transplant
ClinicalTrials.gov study NCT02550639. IPD Sharing: Not stated. Countries: 2. Publications: 3.
Prevalence of Cytomegalovirus, Epstein Barr Virus and Human Herpes 6 Virus in Inflammatory Bowel Disease
ClinicalTrials.gov study NCT00222378. IPD Sharing: Not stated. Countries: 1. Publications: 15.
Safety, Tolerability, and Immunogenicity of the Human Cytomegalovirus Vaccine (V160) in Healthy Adults (V160-001)
ClinicalTrials.gov study NCT01986010. IPD Sharing: YES. Countries: 0. Publications: 2.
Data from: Human cytomegalovirus epidemiology and relationship to tuberculosis and cardiovascular disease risk factors in a rural Ugandan cohort
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Data from: On the relative roles of background selection and genetic hitchhiking in shaping human cytomegalovirus genetic diversity
A central focus of population genetics has been examining the contribution of selective and neutral processes in shaping patterns of intraspecies diversity. In terms of selection specifically, surveys of higher organisms have shown considerable variation in the relative contributions of background selection and genetic hitchhiking in shaping the distribution of polymorphisms, though these analyses have rarely been extended to bacteria and viruses. Here, we study the evolution of a ubiquitous, viral pathogen, human cytomegalovirus (HCMV), by analyzing the relationship among intraspecies diversity, interspecies divergence, and rates of recombination. We show that there is a strong correlation between diversity and divergence, consistent with expectations of neutral evolution. However, after correcting for divergence, there remains a significant correlation between intraspecies diversity and recombination rates, with additional analyses suggesting that this correlation is largely due to the effects of background selection. In addition, a small number of loci, centered on long non-coding RNAs, also show evidence of selective sweeps. These data suggest that HCMV evolution is dominated by neutral mechanisms as well as background selection, expanding our understanding of linked selection to a novel class of organisms.
Fig. 5 in Unusual matrine-adenine hybrids isolated from Sophora davidii and their inhibitory effects on human cytomegalovirus
Fig. 5. Experimental and calculated ECD spectra of 2.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.