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7 results for “hybrid lethality”
Characterizing a lethal mitonuclear incompatibility in naturally hybridizing Xiphophorus swordtails
<p><span>The evolution of reproductive barriers is the first step in the formation of new species and can help us understand the diversification of life on Earth. These reproductive barriers often take the form of "hybrid incompatibilities," where alleles derived from two different species no longer interact properly in hybrids</span><span>. Theory predicts that hybrid incompatibilities may be more likely to arise at rapidly evolving genes</span><span> and that incompatibilities involving multiple genes should be common</span><span>, but there has been sparse empirical data to evaluate these predictions. Here, we describe a mitonuclear incompatibility involving three genes in physical contact within respiratory Complex I </span><span>of </span><span>naturally hybridizing swordtail fish species. Individuals homozygous for mismatched protein combinations fail to complete embryonic development or die as juveniles, while those heterozygous for the incompatibility have reduced </span><span>Complex I </span><span>function and unbalanced representation of parental alleles in the mitochondrial proteome. We find that the impacts of different genetic interactions on survival are non-additive, highlighting subtle complexity in the genetic architecture of hybrid incompatibilities. </span><span>Finally, we</span><span> document the evolutionary history of the genes involved, showing </span><span>signals of accelerated</span> <span>evolution and the first</span> <span>case of </span><span>an incompatibility transferred between species via hybridization. </span></p>
Characterizing a lethal mitonuclear incompatibility in naturally hybridizing Xiphophorus swordtails
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Data from: The hologenomic basis of speciation: gut bacteria cause hybrid lethality in the genus Nasonia
Although the gut microbiome influences numerous aspects of organismal fitness, its role in animal evolution and the origin of new species is largely unknown. Here we present evidence that beneficial bacterial communities in the guts of closely related species of the genus Nasonia form species-specific phylosymbiotic assemblages that cause lethality in interspecific hybrids. Bacterial constituents and abundance are irregular in hybrids relative to parental controls, and antibiotic curing of the gut bacteria significantly rescues hybrid survival. Moreover, feeding bacteria to germ-free hybrids reinstates lethality and recapitulates the expression of innate immune genes observed in conventionally reared hybrids. We conclude that in this animal complex, the gut microbiome and host genome represent a coadapted "hologenome" that breaks down during hybridization, promoting hybrid lethality and assisting speciation.
Data from: The hologenomic basis of speciation: gut bacteria cause hybrid lethality in the genus Nasonia
Although the gut microbiome influences numerous aspects of organismal fitness, its role in animal evolution and the origin of new species is largely unknown. Here we present evidence that beneficial bacterial communities in the guts of closely related species of the genus Nasonia form species-specific phylosymbiotic assemblages that cause lethality in interspecific hybrids. Bacterial constituents and abundance are irregular in hybrids relative to parental controls, and antibiotic curing of the gut bacteria significantly rescues hybrid survival. Moreover, feeding bacteria to germ-free hybrids reinstates lethality and recapitulates the expression of innate immune genes observed in conventionally reared hybrids. We conclude that in this animal complex, the gut microbiome and host genome represent a coadapted "hologenome" that breaks down during hybridization, promoting hybrid lethality and assisting speciation.
Data from: The hologenomic basis of speciation: gut bacteria cause hybrid lethality in the genus Nasonia
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Data from: The hologenomic basis of speciation: gut bacteria cause hybrid lethality in the genus Nasonia
Open the record for dataset details and reuse information.
Lethality of MalE-LacZ hybrid protein shares mechanistic attributes with oxidative component of antibiotic lethality
GEO Series GSE98505. Escherichia coli; Escherichia coli str. K-12 substr. MC4100. 36 samples. Type: Expression profiling by array.
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