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55 results for “hyperthyroidism”
Rapid hyperthyroidism-induced adaptation of Salmonid fish in response to environmental pollution
<p><span>The streams draining volcanic landscapes are often characterized by a complex of factors that negatively affect hydrobionts and lead to a decline of their populations. However, in a number of cases, hydrobionts ensure the resilience of populations througth a range of rapid adaptive changes. Here, we present both field and experimental data shedding light on the physiological basis of adaptation in populations of Dolly Varden charr (<em>Salvelinus malma</em>) differing in the duration of isolation in volcanic streams contaminated with heavy metals. The study reveals that isolated populations have a physiological phenotype that distinguishes them from the populations inhabiting clean waters. They are characterized by a hyperthyroid status accompanied by an increased metabolic rate, elevated activity of antioxidant enzymes, decreased ionic conductivity of tissues and reduced stored energetic reserves. The experimental data elucidate that hyperthyroidism is an adaptive characteristic enhancing the resistance to heavy metal contamination and shaping the evolution of these populations. The similarity of physiological, developmental and morphological changes in isolated populations suggests a common source and mechanisms underpinning their "evolutionary rescue". Thus, populations of <em>S. malma</em> trapped in volcanic streams represent a genuine case of a rapid neuroendocrine-driven adaptation to changing environmental stimuli.</span></p>
Rapid hyperthyroidism-induced adaptation of Salmonid fish in response to environmental pollution
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Direct oral anticoagulants in atrial fibrillation patients with concomitant hyperthyroidism
Objective <p>Patients with hyperthyroidism were excluded from randomized clinical trials of direct oral anticoagulants(DOACs) for stroke prevention in patients with non-valvular atrial fibrillation (NVAF).</p> Methods <p>We performed a nationwide retrospective cohort study using data from the Taiwan National Health Insurance Research Database. We enrolled 3,213 and 1,181 NVAF patients with hyperthyroidism taking DOACs and warfarin, respectively, from June 1, 2012 to December 31, 2017. We also enrolled 53,591 and 16,564 NVAF patients without hyperthyroidism taking DOACs and warfarin, respectively. We used propensity score-based stabilized weights (PSSWs) to balance covariates across the study groups. We also used 1:4 matching on both taking DOACs, with (n=3,213) and without hyperthyroidism (n=12,852); and both taking warfarin, with (n=1,181) and without hyperthyroidism (n=4,724).</p> Results <p>After PSSW, DOAC had a comparable risk of ischemic stroke/systemic embolism (IS/SE) and a lower risk of major bleeding (hazard ratio (HR):0.65; [95% confidential interval (CI):0.44-0.96]; <i>P</i>=0.0295) than warfarin among patients with hyperthyroidism. There were comparable risks of IS/SE and major bleeding between those patients with and without hyperthyroidism. However, patients taking warfarin with hyperthyroidism had a lower risk of IS/SE than those without hyperthyroidism (HR:0.61; [95%CI:0.43-0.86]; <i>P</i>=0.0050).</p> Conclusion <p>Among NVAF Asian patients with concomitant hyperthyroidism, DOACs may be an effective and safer alternative to warfarin. Thromboprophylaxis with DOACs may be considered for such patients, and it is important to validate this finding in further prospective study.</p>
Supplemental materials for "Hyperthyroidism in Graves' disease causes sleep disorders related to sympathetic hypertonia"
<p>Supplemental Figure 1. Study protocol. On the first visit, all participants that met the inclusion criteria and did not meet the exclusion criteria were enrolled after providing written informed consent. On the second visit, an evaluation was performed for all participants (Evaluation No. 1). On the additional visit, patients in the HT group were observed for 12 months and reevaluated using the same parameters (Evaluation No.2).</p> <p>*Vital signs, general health conditions (renal dysfunction etc.), the Pittsburgh Sleep Quality Index, portable sleep monitoring, thyroid function test (TSH, Free thyroxine), TSH receptor autoantibody, and urinary total metanephrines were included in the evaluation.</p> <p>Abbreviations: CR, normal control; HT, hyperthyroidism; NF, normal thyroid function.</p>
Hyperthyroid Follow-Up Study
ClinicalTrials.gov study NCT02989103. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Follow-up Study of the RAI-Treated Hyperthyroid Patients
ClinicalTrials.gov study NCT00471458. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Postoperative Hyperthyroidism
ClinicalTrials.gov study NCT01095341. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Serum Betatrophin Levels and Its Influencing Factors in Patients With Hyperthyroidism
ClinicalTrials.gov study NCT02812888. IPD Sharing: YES. Countries: 1. Publications: 8.
Does Radioiodine Treatment Prevent Atrial Fibrillation and Bone Loss in Endogenous Subclinical Hyperthyroidism?
ClinicalTrials.gov study NCT00151723. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Comparison of Different Doses of 131I in Severe Graves' Hyperthyroidism
ClinicalTrials.gov study NCT01039818. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Thumb-ECG Ambulant Screening for Atrial Fibrillation in Patients Treated for Hyperthyroidism (TAMBOURINE)
ClinicalTrials.gov study NCT01945229. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Effect of Hyperthyroidism and Its Treatment in Graves' Disease to Early Marker of Atherosclerosis
ClinicalTrials.gov study NCT05118542. IPD Sharing: NO. Countries: 1. Publications: 6.
Morbidity and Mortality Associated With the Care Journey in Children and Adolescents With Hyperthyroidism
ClinicalTrials.gov study NCT03951532. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Low Doses of Cholestyramine in the Treatment of Hyperthyroidism
ClinicalTrials.gov study NCT00677469. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Selenium Supplementation Versus Placebo in Patients With Graves' Hyperthyroidism
ClinicalTrials.gov study NCT01611896. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Thermogenesis in Hyperthyroidism and Effect of Anti-Adrenergic Therapy
ClinicalTrials.gov study NCT03379181. IPD Sharing: NO. Countries: 1. Publications: 2.
Exercise Capacity, Physical Activity Levels in Patients With Hyperthyroid
ClinicalTrials.gov study NCT04825964. IPD Sharing: NO. Countries: 1. Publications: 6.
Efficacy and Safety of Cholestyramine and Prednisolone as Adjunctive Therapy in Treatment of Overt Hyperthyroidism
ClinicalTrials.gov study NCT03303053. IPD Sharing: UNDECIDED. Countries: 1. Publications: 16.
Direct oral anticoagulants in atrial fibrillation patients with concomitant hyperthyroidism
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Insulin Resistance in Relation to Hyperthyroidism and Hypothyroidism
ClinicalTrials.gov study NCT06399796. IPD Sharing: Not stated. Countries: 0. Publications: 6.
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