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Dataset results
31 results for “hypogonadotropic hypogonadism”
Safety and Efficacy of BGS649 in Male Obese Subjects With Hypogonadotropic Hypogonadism
ClinicalTrials.gov study NCT02730169. IPD Sharing: NO. Countries: 4. Publications: 1.
GnRH deficient patients with congenital hypogonadotropic hypogonadism: Novel genetic findings in ANOS1, RNF216, WDR11, FGFR1, CHD7 and POLR3A genes
<p><b>Background: </b>Congenital hypogonadotropic hypogonadism (CHH) is a rare genetic disease caused by Gonadotropin-Releasing Hormone (GnRH) deficiency. So far a limited number of variants in several genes have been associated with the pathogenesis of the disease. In this original research and review manuscript the retrospective analysis of known variants in <i>ANOS1</i> (<i>KAL1)</i>, <i>RNF216</i>,<i> WDR11</i>,<i> FGFR1</i>,<i> CHD7</i> and <i>POLR3A</i> genes is described, along with novel variants identified in patients with CHH by the present study.</p> <p><b>Methods:</b> Seven GnRH deficient unrelated Cypriot patients underwent whole exome sequencing (WES) by Next Generation Sequencing (NGS). The identified novel variants were initially examined by <i>in silico </i>computational algorithms and structural analysis of their predicted pathogenicity at the protein level was confirmed.</p> <p><b>Results:</b> In four nonrelated GnRH males, a novel X-linked pathogenic variant in <i>ANOS1 </i>gene, two novel autosomal dominant (AD) probably pathogenic variants in <i>WDR11 </i>and <i>FGFR1 </i>genes and one rare AD probably pathogenic variant in <i>CHD7</i> gene were identified. A rare autosomal recessive (AR) variant in the <i>SRA1</i> gene was identified in homozygosity in a female patient, whilst two other male patients were also respectively found to carry novel or previously reported rare pathogenic variants in more than one genes; <i>FGFR1</i>/<i>POLR3A </i>and <i>SRA1/RNF216</i>.</p> <p><b>Conclusion: </b>This report embraces the description of novel and previously reported rare pathogenic variants in a series of genes known to be implicated in the biological development of CHH. Notably, patients with CHH can harbor pathogenic rare variants in more than one gene which raises the hypothesis of locus-locus interactions providing evidence for digenic inheritance. The identification of such aberrations by NGS can be very informative for the management and future planning of these patients.</p>
Rec-LH PD and Safety Profile in Hypogonadotropic Hypogonadism Men
ClinicalTrials.gov study NCT04189133. IPD Sharing: NO. Countries: 1. Publications: 8.
Examination of Idiopathic Hypogonadotropic Hypogonadism (IHH)and Kallmann Syndrome (KS)
ClinicalTrials.gov study NCT00392756. IPD Sharing: Not stated. Countries: 1. Publications: 38.
Sequential Therapy for Hypogonadotropic Hypogonadism
ClinicalTrials.gov study NCT01403532. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Study of the Efficacy and Safety of Corifollitropin Alfa (MK-8962) in Combination With Human Chorionic Gonadotropin (hCG) in Adult Men With Hypogonadotropic Hypogonadism (HH) (P07937)
ClinicalTrials.gov study NCT01709331. IPD Sharing: NO. Countries: 0. Publications: 1.
Efficacy and Safety of Long Term Use of hCG or hCG Plus hMG in Males With Isolated Hypogonadotropic Hypogonadism (IHH)
ClinicalTrials.gov study NCT03687606. IPD Sharing: YES. Countries: 1. Publications: 2.
Human Menopausal Gonadotropin Combining With Human Chorionic Gonadotropin Treat Congenital Hypogonadotropic Hypogonadism
ClinicalTrials.gov study NCT02880280. IPD Sharing: NO. Countries: 1. Publications: 1.
GnRH deficient patients with congenital hypogonadotropic hypogonadism: Novel genetic findings in ANOS1, RNF216, WDR11, FGFR1, CHD7 and POLR3A genes
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A Phase 2a Pharmacodynamic Study of TAK-448 in Participants With Hypogonadotropic Hypogonadism
ClinicalTrials.gov study NCT02369796. IPD Sharing: Not stated. Countries: 1. Publications: 0.
A Multi-Center Study in Men With Acquired Hypogonadotropic Hypogonadism to Compare Changes in Body Composition and Metabolic Parameters With Diet and Exercise in Conjunction With Treatment With 12.5 m
ClinicalTrials.gov study NCT02651688. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Effects on the Brain of Lupron Induced Hypogonadotropic Hypogonadism With and Without Testosterone Replacement
ClinicalTrials.gov study NCT00001412. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Efficacy and Safety of Pulsatile Gonadotropin Releasing Hormone Pump Treatment in Patients With Idiopathic Hypogonadotropic Hypogonadism
ClinicalTrials.gov study NCT02310074. IPD Sharing: Not stated. Countries: 0. Publications: 1.
A Study Using Recombinant Human Luteinizing Hormone (r-hLH, Luveris®) in the Treatment of Chinese Women With Hypogonadotropic Hypogonadism
ClinicalTrials.gov study NCT01084265. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Opioid Antagonism in Hypogonadotropic Hypogonadism
ClinicalTrials.gov study NCT04975334. IPD Sharing: NO. Countries: 1. Publications: 0.
Luveris® (Lutropin Alfa for Injection) in Women With Hypogonadotropic Hypogonadism (Luteinizing Hormone [LH] Less Than [<] 1.2 International Unit Per Liter [IU/L])
ClinicalTrials.gov study NCT00328926. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Efficacy and Safety of Corifollitropin Alfa (MK-8962) in Combination With Human Chorionic Gonadotropin (hCG) in Adolescent Males With Hypogonadotropic Hypogonadism (HH) (MK-8962-043)
ClinicalTrials.gov study NCT03019575. IPD Sharing: NO. Countries: 6. Publications: 0.
Hypogonadotropic Hypogonadism in Obese Young Males
ClinicalTrials.gov study NCT03245827. IPD Sharing: NO. Countries: 1. Publications: 0.
Safety and Efficacy of BGS649 in Obese, Hypogonadotropic Hypogonadal Men
ClinicalTrials.gov study NCT01200862. IPD Sharing: NO. Countries: 2. Publications: 0.
LutrePulse Hypogonadotropic Hypogonadism
ClinicalTrials.gov study NCT01976728. IPD Sharing: Not stated. Countries: 2. Publications: 0.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
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International Brain Laboratory public data
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OpenNeuro
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