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295 results for “hypothalamus”
Fig. 1 in Glyphosate commercial formulation effects on preoptic area and hypothalamus of Cardinal Neon Paracheirodon axelrodi (Characiformes: Characidae)
Fig. 1. Cross-section of preoptic area (AP) and posterior diencephalic region (PDR) of Paracheirodon axelrodi showing its different neuronal nuclei. a. Panoramic view of AP showing different neuronal nuclei. b. Panoramic view of PDR, including HT neuronal nuclei. Technique: high resolution optical microscopy (HROM) Bar 100 μm.
Full summary statistics of mixQTL for GTEx v8 Brain_Hypothalamus
The mixQTL method is described in paper doi.org/10.1101/2020.04.22.050666. Please cite the original paper if using the data.
Psychedelic drug effects on reactivity of the paraventricular nucleus of the hypothalamus and threat responding behavior
<p>Psychedelics have experienced renewed interest following studies suggesting potential therapeutic effects in patients with affective disorders. While clinical results look promising, the neurobiological mechanisms underlying acute and prolonged effects of psychedelics remain unclear. Many psychiatric disorders involve hypothalamic-pituitary-adrenal (HPA) axis dysfunction. The paraventricular nucleus of the hypothalamus (PVN) is a midline hypothalamic nucleus that plays an integral role in HPA stress reactivity, autonomic functioning, social behavior, and many other affective processes. We investigated the effect of psilocin, the psychoactive metabolite of psilocybin, on PVN reactivity in Sprague Dawley rats. Psilocin increased stimulus-independent activity as measured by c-Fos expression in the PVN of male and female rats. Psilocin also increased PVN reactivity (ΔF/F) to an aversive air-puff stimulus in males but not females. PVN reactivity was restored at 2- and 7-days post-injection with no group differences. Additionally, we found that prior psilocin injection did not affect PVN reactivity following acute restraint stress. Experimental groups were sub-classified by baseline threat responding and psilocin-induced increases in male PVN reactivity were found to be driven by baseline active threat responders. Overall, these data demonstrate that the PVN is a significant site of psychedelic drug action with implications for threat responding behavior.</p>
Psychedelic drug effects on reactivity of the paraventricular nucleus of the hypothalamus and threat responding behavior
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A distinct hypothalamus-habenula circuit governs risk preference raw data
<p>Here we deposit raw data from in vivo two-photon, silicon probe and multi-fiber recordings from the Article 'A distinct hypothalamus-habenula circuit governs risk preference' by Groos et al. </p>
Evaluation of Efficacy and Hypothalamus-pituitary-adrenal Axis Suppression Due to Corticosteroids Intrabursal Injection
ClinicalTrials.gov study NCT01652495. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Data from: KCNB1-Leptin receptor complexes couple electric and endocrine function in the melanocortin neurons of the hypothalamus
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MERFISH data from the murine hypothalamus in health and under induced sickness states
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Data from quantitative real-time PCR of corticotropin-releasing hormone and glucocorticoid receptor in the hippocampus and hypothalamus of rats subjected to midline fluid percussion injury or control sham surgery.
<p>These files contain all data from quantitative real-time PCR of corticotropin-releasing hormone (CRH) and glucocorticoid receptor (GR) measured in the hippocampus and hypothalamus of male and female rats. Rats were randomly assigned to a treatment group before the initiation of the study. Rats received a control sham surgery or were subjected to midline fluid percussion injury to induce a diffuse traumatic brain injury. Tissue biopsies were collected at 7 days post-injury and analyzed via quantitative real-time PCR. </p> <p> </p>
Functional Study of the Hypothalamus in Magnetic Resonance Imaging (MRI) in Polycystic Ovary Syndrome (PCOS)
ClinicalTrials.gov study NCT03043924. IPD Sharing: NO. Countries: 1. Publications: 1.
Hypothalamus Connectivity in Chronic and Episodic Migraine
ClinicalTrials.gov study NCT02328976. IPD Sharing: NO. Countries: 1. Publications: 2.
Deep Brain Stimulation of the Lateral Hypothalamus to Augment Motor Function of Patients With Spinal Cord Injury
ClinicalTrials.gov study NCT04965727. IPD Sharing: NO. Countries: 1. Publications: 10.
Data from quantitative real-time PCR of corticotropin-releasing hormone and glucocorticoid receptor in the hippocampus and hypothalamus of rats subjected to midline fluid percussion injury or control sham surgery.
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Fig. 2 in Glyphosate commercial formulation effects on preoptic area and hypothalamus of Cardinal Neon Paracheirodon axelrodi (Characiformes: Characidae)
Fig. 2. Cross-sections of preoptic area (AP) of Paracheirodon axelrodi for different treatments with Roundup ActivoẈ. MC cells are present at different AP nuclei in all treatments. Mid dorsal telencephalic nucleus (MD). Anterior preoptic parvocelular nucleus (PPa). Lateral dorsal telencephalic nucleus (LD). Adjacent blood vessels (AV) and internal blood vessels (IV) are shown. MC cells are shown by black arrows. Technique: high resolution optical microscopy (HROM). Bar 25 μm.
Fig. 4 in Glyphosate commercial formulation effects on preoptic area and hypothalamus of Cardinal Neon Paracheirodon axelrodi (Characiformes: Characidae)
Fig. 4. Number of AP and PDR parenchyma MC cells found for each one of Roundup ActivoẈ treatments. Each value represents mean ± SD. Different letters correspond to significant differences (P<0.05 values). The treatments are in units of mg / L. N= 3.
Fig. 3 in Glyphosate commercial formulation effects on preoptic area and hypothalamus of Cardinal Neon Paracheirodon axelrodi (Characiformes: Characidae)
Fig. 3. Cross-sections of posterior diencephalic region (PDR) of Paracheirodon axelrodi for different treatments with Roundup ActivoẈ. MC cells were found at different neuronal nuclei of posterior diencephalic area (PDR) in all treatments. Optic Tectum (TeO), gray periventricular area of optic tectum (PGZ), Torus semicircularis (TS), Torus lateralis (TLa), Hypothalamus with ventral are of periventricular hypothalamus (Hv) and anterior tuberal nucleus (ATN). Adjacent blood vessels (AV), internal blood vessels (IV), nerve (N). MC cells are shown by black arrows. Technique: high resolution optical microscopy (HROM). Bar 25 µm.
Dynamic encoding of social threat and spatial context in the hypothalamus - calcium activity recordings and behavioural dataset
<p>Social aggression and avoidance are defensive behaviors expressed by territorial animals in a manner appropriate to spatial context and experience. The ventromedial hypothalamus controls both social aggression and avoidance, suggesting that it may encode an general internal state of threat modulated by space and experience. Here we show that neurons in the mouse ventromedial hypothalamus are activated both by the presence of a social threat as well as by a chamber where social defeat previously occurred. Moreover, under conditions where the animal could move freely between a home and defeat chamber, firing activity emerged that predicted the animal's position, demonstrating the dynamic encoding of spatial context in the hypothalamus. Finally, we found that social defeat induced a functional reorganization of neural activity as optogenetic activation could elicit avoidance after, but not before social defeat. These findings reveal how the hypothalamus dynamically encodes spatial and sensory cues to drive social behaviors.</p>
Homeostatic regulation of REM sleep by the preoptic area of the hypothalamus
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Transcriptional conservation and innovation of cell types across mammalian hypothalamus development
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Dynamic encoding of social threat and spatial context in the hypothalamus - calcium activity recordings and behavioural dataset
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.