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175
datasets available to search
ShareScore release 0.9.0
Dataset results
175 results for “imiquimod”
Safety and Effectiveness Study of Imiquimod Creams for the Treatment of Actinic Keratoses (AKs)
ClinicalTrials.gov study NCT00603798. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Imiquimod for Breast Cancer Patients With Chest Wall Recurrence or Skin Metastases
ClinicalTrials.gov study NCT00899574. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Open-label Study to Evaluate Clearance of Superficial Basal Cell Carcinoma After Use of Imiquimod 5% Cream
ClinicalTrials.gov study NCT00189306. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Betaglucin 0.2% Versus Imiquimod 5% in Treatment of Ano-genital Warts: Combined Results From Triple Blind Controlled Study
ClinicalTrials.gov study NCT03901690. IPD Sharing: YES. Countries: 1. Publications: 2.
Combining Topical Imiquimod 5% Cream With a Pulsed Dye Laser to Treat Port Wine Stain Birthmarks
ClinicalTrials.gov study NCT00585247. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Imiquimod, Fluorouracil, or Observation in Treating HIV-Positive Patients With High-Grade Anal Squamous Skin Lesions
ClinicalTrials.gov study NCT02059499. IPD Sharing: UNDECIDED. Countries: 2. Publications: 1.
Safety and Effectiveness Study of Imiquimod Creams for Treatment of Actinic Keratoses (AKs)
ClinicalTrials.gov study NCT00605176. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Open-Label Safety Study to Evaluate Imiquimod Cream, 5% for Large Areas of Actinic Keratosis
ClinicalTrials.gov study NCT00116649. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Topical Imiquimod and Abraxane in Treating Patients With Advanced Breast Cancer
ClinicalTrials.gov study NCT00821964. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Combination Therapy With Imiquimod Cream 5% and Tazarotene Cream 0.1% for the Treatment of Lentigo Maligna
ClinicalTrials.gov study NCT00707174. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Topical Imiquimod in Conjunction With Nd:YAG Laser for Tattoo Removal
ClinicalTrials.gov study NCT00638651. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Neoadjuvant Imiquimod Immunotherapy for Oral Cancer
ClinicalTrials.gov study NCT04883645. IPD Sharing: NO. Countries: 1. Publications: 1.
NY-ESO-1 Protein Vaccine With Imiquimod in Melanoma (Adjuvant Setting)
ClinicalTrials.gov study NCT00142454. IPD Sharing: NO. Countries: 1. Publications: 1.
Dataset related to article "Poly(I:C) stimulation is superior than Imiquimod to induce the antitumoral functional profile of tumor-conditioned macrophages."
<p>Macrophage plasticity is the ability of mononuclear phagocytes to change phenotype, function, and genetic reprogramming upon encounter of specific local stimuli. In the tumor microenvironment, Tumor-Associated Macrophages (TAMs) acquire an immune-suppressive and tumor-promoting phenotype. With the aim to re-educate TAMs to antitumor effectors, in this study, we used two immunestimulatory compounds: the TLR7 agonist Imiquimod (IMQ) and the TLR3 agonist Poly(I:C). To better mimic in vitro the response of TAMs, we used Tumor-Conditioned Macrophages (TC-Mϕ) differentiated in the presence of tumor cell supernatants. Our results show that TC-Mϕ respond differently from conventional M2-polarized macrophages. Upon stimulation with IMQ, TC-Mϕ did not upregulate major histocompatibility complex (MHC II) molecules and unexpectedly expressed increased CD206. With both compounds, TC-Mϕ produced higher levels of inflammatory cytokines than M2 macrophages. IMQ and Poly(I:C) differed in the types of regulated genes and secreted mediators. Reflecting their signaling pathways, only IMQ significantly induced IL-1β and IL-6, while only Poly(I:C) stimulated CXCL10, and both upregulated CCL5. Of note, using a novel cytotoxicity assay, Poly(I:C), but not IMQ, was effective in triggering the cytotoxic activity of TC-Mϕ against cancer cells. Overall, the results demonstrate that Poly(I:C) stimulation of TC-Mϕ is superior than IMQ in terms of macrophage re-education toward antitumor effectors.</p>
Intra-dermal With Topical Imiquimod Pretreatment Versus Intra-muscular Hepatitis B Vaccination in IBD Patients
ClinicalTrials.gov study NCT04083157. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Imiquimod Treatment of Residual or Recurrent CIN Lesions: a Study Protocol
ClinicalTrials.gov study NCT02669459. IPD Sharing: UNDECIDED. Countries: 1. Publications: 24.
Combination Therapy of Topical Imiquimod Plus Multipeptide Vaccination for Cutaneous Metastases of Melanoma
ClinicalTrials.gov study NCT01264731. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Imiquimod and Influenza Vaccine for Immunocompromised Patients
ClinicalTrials.gov study NCT02960815. IPD Sharing: NO. Countries: 1. Publications: 3.
Imiquimod Plus Antimony Immunochemotherapy for Cutaneous Leishmaniasis
ClinicalTrials.gov study NCT00257530. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Imiquimod Versus Photodynamic Therapy of Actinic Keratoses in Organ Transplant Recipients
ClinicalTrials.gov study NCT01538901. IPD Sharing: Not stated. Countries: 1. Publications: 6.
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.