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ShareScore release 0.9.0
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52 results for “immediate early genes”
Dim artificial light at night alters immediate early gene expression throughout the avian brain
<p>Artificial light at night (ALAN) is a pervasive pollutant that alters physiology and behavior. However, the underlying mechanisms triggering these alterations are unknown, as previous work shows that dim levels of ALAN may have a masking effect, bypassing the central clock. Light stimulates neuronal activity in numerous brain regions which could in turn activate downstream effectors regulating physiological response. In the present study, taking advantage of immediate early gene (IEG) expression as a proxy for neuronal activity, we determined the brain regions activated in response to ALAN. We exposed zebra finches to dim ALAN (1.5 lux) and analyzed 24 regions throughout the brain. We found that the overall expression of two different IEGs, cFos and ZENK, in birds exposed to ALAN were significantly different from birds inactive at night. Additionally, we found that ALAN-exposed birds had significantly different IEG expression from birds inactive at night and active during the day in several brain areas associated with vision, movement, learning and memory, pain processing, and hormone regulation. These results give insight into the mechanistic pathways responding to ALAN that underlie downstream, well-documented behavioral and physiological changes.</p>
Dim artificial light at night alters immediate early gene expression throughout the avian brain
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Role of immediate early genes in the development of salivary gland organoids in polyisocyanopeptide hydrogels
GEO Series GSE220084. Homo sapiens. 19 samples. Type: Expression profiling by high throughput sequencing.
Activation of immediate early response genes initiates a restorative gene expression program during each arousal from torpor in hibernating 13-lined ground squirrels
GEO Series GSE207211. Ictidomys tridecemlineatus. 31 samples. Type: Expression profiling by high throughput sequencing.
Rapid transcription of arc/arg3.1 and other very fast immediate early genes in response to neuronal activity is mediated by a stalled RNA polymerase II mechanism
GEO Series GSE22878. Rattus norvegicus. 1 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Opto-seq reveals input-specific immediate early gene induction in ventral tegmental area cell types
GEO Series GSE235086. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
NR4A1 suppresses cancer replication stress through R-loop-dependent inhibition of immediate early gene transcriptional elongation [bulk RNA-seq]
GEO Series GSE161779. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
Control of immediate early gene expression by CPEB4-mediated mRNA degradation [CLIP-seq]
GEO Series GSE188693. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing; Other.
NR4A1 suppresses cancer replication stress through R-loop-dependent inhibition of immediate early gene transcriptional elongation
GEO Series GSE161853. Homo sapiens. 111 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
A DGCR8/FLII-dominated on-off switch for immediate-early genes governs embryo implantation in mouse and human [RNA-seq]
GEO Series GSE256381. Mus musculus; Homo sapiens. 171 samples. Type: Expression profiling by high throughput sequencing.
Differential expression of Dusp1 and immediate early response genes in hippocampus of rats, subjected to forced swimming test
GEO Series GSE162524. Rattus norvegicus. 25 samples. Type: Expression profiling by high throughput sequencing.
Identification of immediate early genes in the nervous system of snail Helix lucorum
GEO Series GSE123558. Helix lucorum. 35 samples. Type: Expression profiling by high throughput sequencing.
Chromatin Remodeling and Immediate Early Gene Activation by SLFN11 in Response to Replication Stress
GEO Series GSE140938. Homo sapiens. 52 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
Stress-induced splicing activation of immediate early genes by nuclear speckle reorganization
GEO Series GSE231521. Homo sapiens. 36 samples. Type: Expression profiling by high throughput sequencing.
Stress-induced splicing activation of immediate early genes by nuclear speckle reorganization [ThioU]
GEO Series GSE231520. Homo sapiens. 8 samples. Type: Expression profiling by high throughput sequencing.
Stress-induced splicing activation of immediate early genes by nuclear speckle reorganization [HLs]
GEO Series GSE231519. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Cohesins Repress KSHV Immediate Early Gene Transcription During Latency
GEO Series GSE38411. Homo sapiens; Human gammaherpesvirus 8. 5 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
THOC5 controls 3´end-processing of immediate early genes via interaction with CPSF100
GEO Series GSE59561. Mus musculus. 2 samples. Type: Expression profiling by array; Non-coding RNA profiling by array.
A DGCR8/FLII-dominated on-off switch for immediate-early genes governs embryo implantation in mouse and human [smallRNA-seq]
GEO Series GSE256197. Mus musculus. 8 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Analysis of immediate-early induced target genes of the BMP and WNT pathways in human ES cells
GEO Series GSE97625. Homo sapiens. 4 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.