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28
datasets available to search
ShareScore release 0.9.0
Dataset results
28 results for “immunostimulant”
Evaluation of the immunostimulant effect of microvesicles of Lactobacillus acidophilus isolated from wild Rattus norvegicus.
<p><span>Lactic acid bacteria are components of the microbiota of the gastrointestinal tract in both humans and animals and are widely used as probiotics. The bacterial strain <em>Lactobacillus sp</em>. is the most related to probiotic activity and released<span> </span>membrane microvesicles (MVs). Some of their primary functions are to carry and transmit antigens to the host tissues and modulate the host defense responses. In the present study, <em>Lactobacillus acidophilus</em> was isolated from the ileum of free-living <em>Rattus norvegicus</em> to evaluate the immunostimulant effect of their MVs in two biological models. MVs from <em>L. acidophilus</em> were characterized using sodium dodecyl sulfate-polyacrylamide gel electrophoresis, electron microscopy</span><span>, and nanoparticle tracking analysis. The immunostimulant effect of</span><span> MVs</span><span> from </span><em><span>L. acidophilus</span></em><span> on ovine abomasal explants, previously stimulated with 30 µg/1h of MVs and subsequently challenged with third-stage larvae (L3) of <em>Haemonchus contortus</em>, was probed, demonstrating a decrease in the percentage of larvae association, and favoring the migration of inflammatory cells to the infection site. In contrast, cells line of the RAW 264.7 were stimulated by 10 µg/3h of MVs from <em>L. acidophilus</em> to evaluate their activation through the expression of transcripts coding for IL-1β and TNF-α. In both cases, the immunostimulatory effect</span><span>s of </span><span>MVs<em> </em><span>from <em>L. acidophilus</em></span> isolated from free-living <em>R. norvegicus</em> were verified, demonstrating that these structures are capable of immunostimulated the </span><span>evaluated biological models and </span><span>could carried important antigen that can be considerate in a formulation to promote the intestinal health in livestock production.<span> </span>The present study is the first report of MVs secreted by <em>L. acidophilus</em> isolated from free-living <em>R. norvegicus </em>caring that this rodent is resistant to many bacterial pathogens that normally affect the gastrointestinal tract of other mammals.</span></p> <p><span>In the atachment file we present the data obtained of the porcentage of asocciation and porcentage of mortality of L3 stage larvae from <em>H. contort</em></span><span><em>u</em>s in abomasal tissue stimulated with microvesicles from <em>L. acidophilus</em>. In the other hand the expression of IL-1</span><span>β</span><span> and TNF</span><span>α. </span><span> mRNA from RAW 264.7 cells stimulated with microvesicles from <em>L. acidophilus.</em> </span></p>
Fig 1 in A mini-review: Potential of Phyllanthus niruri L as immunostimulators in fish aquaculture
Fig 1: Phyllanthus niruri L. Plant
A Study On An Immunostimulant Antibody In Combination With Chemotherapy For Advanced Cancer Of The Pancreas
ClinicalTrials.gov study NCT00711191. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Influence of Nonspecific Immunostimulation on Changes in the Concentration of iNKT Cells
ClinicalTrials.gov study NCT04802616. IPD Sharing: Not stated. Countries: 1. Publications: 15.
Immunostimulating Interstitial Laser Thermotherapy in Breast Cancer
ClinicalTrials.gov study NCT03039127. IPD Sharing: NO. Countries: 1. Publications: 6.
Immunostimulating Interstitial Laser Thermotherapy in Pancreatic Cancer
ClinicalTrials.gov study NCT02973217. IPD Sharing: NO. Countries: 1. Publications: 1.
The Effects of Immunostimulation With GM-CSF or IFN-y on Immunoparalysis Following Human Endotoxemia
ClinicalTrials.gov study NCT01374711. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Impact of Immunostimulating Nutrition on the Outcome of Surgery
ClinicalTrials.gov study NCT00558155. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Standard and Immunostimulating Enteral Nutrition in Surgical Patients
ClinicalTrials.gov study NCT00576940. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Supporting Data - Temperature and immunostimulants modulate transcription of the ubiquitin and apoptosis pathways in the Antarctic Harpagifer antarcticus and sub-Antarctic Harpagifer bispinis
<p>C<sub>t</sub> values obtained from Real-Time PCR (<em>ß-ACTIN</em>, <em>UBE3</em>, <em>SMAC/DIABLO</em> and <em>BAX</em> genes) of cDNA from liver, gills and spleen of <em>Harpagifer antarcticus</em> and <em>Harpagifer bispinis</em> fish stimulated with LPS, Poly I:C or non-stimulated (control, PBS-injected) under three temperatures (2, 5 and 8°C).</p>
Evaluation of immunostimulating effects of mineral heat ware in pig
GEO Series GSE131821. Sus scrofa. 12 samples. Type: Expression profiling by array.
Trancriptome profiling of murine lung after pneumococcal respiratory infection, antibiotic administation, and treatment with immunostimulants
GEO Series GSE118860. Mus musculus. 24 samples. Type: Expression profiling by array.
Short duplex RNAs induce potent immunostimulation via Hoogsteen G-G base pairing-mediated dimerization
GEO Series GSE181827. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Analysis of the long-lived responses induced by immunostimulants and their effects on a viral infection in zebrafish (Danio rerio)
GEO Series GSE113241. Danio rerio. 32 samples. Type: Expression profiling by array.
Improved Innate and Adaptive Immunostimulation by Genetically Modified HIV-1 Protein Expressing NYVAC Vectors
GEO Series GSE26239. Homo sapiens. 80 samples. Type: Expression profiling by array.
Immunostimulating Interstitial Laser Thermotherapy in Solid Cancers
ClinicalTrials.gov study NCT02690428. IPD Sharing: NO. Countries: 1. Publications: 0.
Immunostimulating Interstitial Laser Thermotherapy in Malignant Melanoma
ClinicalTrials.gov study NCT02650492. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Improving Survival of COlorectal LIver Metastases by RFA-mediated Immunostimulation
ClinicalTrials.gov study NCT04798898. IPD Sharing: NO. Countries: 1. Publications: 0.
Percutaneous Immunostimulating Interstitial Laser Thermotherapy in Pancreatic Cancer
ClinicalTrials.gov study NCT03187587. IPD Sharing: NO. Countries: 1. Publications: 0.
Functional Transition of CD11b+CD33+HLA-DR-/lowCD14- G-MDSC: Immunostimulation to Immunosuppression Post Allo-HSCT
GEO Series GSE260477. Homo sapiens. 14 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.