Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
84
datasets available to search
ShareScore release 0.9.0
Dataset results
84 results for “infection intensity”
Figure 1 in Cyclosporine A increases the intensity of Toxocara canis infection in swiss mice
Figure 1. Relative mRNA transcription of interleukins IL-4, IL-10, IL-12 in splenocytes of Swiss mice treated with CsA (50 mg/Kg), infected with Toxocara canis eggs and euthanized 30 days postinoculation.
Fig. 1 in Variable changes in nematode infection prevalence and intensity after Rabbit Haemorrhagic Disease Virus emerged in wild rabbits in Scotland and New Zealand
Fig. 1. Differences in mean intensity of nematode parasite infection in rabbits sampled seasonally from New Zealand and Scotland before the spread of RHDV (a), rabbits sampled seasonally from Sotland before and after RHDV (b), and rabbits sampled in autumn season from New Zealand and Scotland before and after RHDV (c). Nematode parasites included T. retortaeformis (i) G. strigosum (ii) and P. ambiguus (iii) found in rabbits sampled in spring (Spr), summer (Sum), autumn (Aut) and winter (Win).
Data from: Dynamic effects of thermal acclimation on chytridiomycosis infection intensity and transmission potential in Xenopus laevis
Open the record for dataset details and reuse information.
Data from: Reduced skin bacterial diversity correlates with increased pathogen infection intensity in an endangered amphibian host
The fungal pathogen Batrachochytrium dendrobatidis (Bd) infects the skin of amphibians, and has caused severe declines and extinctions of amphibians globally. In this study, we investigate the interaction between Bd and the bacterial skin microbiome of the endangered Sierra Nevada yellow-legged frog, Rana sierrae, using both culture-dependent and culture-independent methods. Samples were collected from two populations of R. sierrae that likely underwent Bd epizootics in the past, but that continue to persist with Bd in an enzootic disease state, and we address the hypothesis that such "persistent" populations are aided by mutualistic skin microbes. Our 16S rRNA metabarcoding data reveal that the skin microbiome of highly infected juvenile frogs is characterized by significantly reduced species richness and evenness, and by strikingly lower variation between individuals, compared to juveniles and adults with lower infection levels. Over 90% of DNA sequences from the skin microbiome of highly infected frogs were derived from bacteria in a single order, Burkholderiales, compared to just 54% in frogs with lower infection levels. In a culture-dependent Bd-inhibition assay, the bacterial metabolites we evaluated all inhibited the growth of Bd. Together, these results illustrate the disruptive effects of Bd infection on host skin microbial community structure and dynamics, and suggest possible avenues for the development of anti-Bd probiotic treatments.
Data from: Flowering plant composition shapes pathogen infection intensity and reproduction in bumble bee colonies
<p><span>Pathogens pose significant threats to pollinator health and food security. Pollinators can transmit diseases during foraging, but the consequences of plant species composition for infection is unknown. In agroecosystems, flowering strips or hedgerows are often used to augment pollinator habitat. We used canola as a focal crop in tents, and manipulated flowering strip composition using plant species we had previously shown to result in higher or lower bee infection in short-term trials. We also manipulated initial colony infection to assess impacts on foraging behavior. Flowering strips using high-infection plant species nearly doubled bumble bee colony infection intensity compared to low-infection plant species, with intermediate infection in canola-only tents. Both infection treatment and flowering strips reduced visits to canola, but we saw no evidence that infection treatment shifted foraging preferences. Although high-infection flowering strips increased colony infection intensity, colony reproduction was improved with any flowering strips compared to canola alone. Effects of flowering strips on colony reproduction were explained by nectar availability, but effects of flowering strips on infection intensity were not. Thus, flowering strips benefited colony reproduction by adding floral resources, but certain plant species also come with a risk of increased pathogen infection intensity.</span></p>
Effects of an alternative host on the prevalence and infection intensity of a bumble bee parasite
<p>Several bee parasites are transmitted through flowers, and some of them can infect multiple host species. Given the shared use of flowers by bee species, parasites can potentially encounter multiple host species, which could affect the evolution of parasite virulence. We used the trypanosomatid parasite <em>Crithidia bombi</em> and its host, the common eastern bumble bee (<em>Bombus impatiens</em>), to explore the effect of infecting an alternative host, the alfalfa leaf-cutter bee (<em>Megachile rotundata</em>), on parasite infectivity and ability to replicate. We conducted a serial passage experiment on primary and alternative hosts, assessing infectivity and intensity of infection during five passes. Parasite cells from each pass through the alternative host were also used to infect a group of primary hosts. We found that serial passes through the alternative host increased infectivity, but there was no effect on intensity of infection. Interestingly, both the probability and intensity of infection on the primary host increased after serial passage through the alternative host. This increase in intensity of infection could be due to maladaptation after selection of new <em>C. bombi</em> strains has occurred in the alternative host. This study suggests that host switching has the potential to affect the adaptation of bee parasites to their hosts.</p>
Short Duration High Intensity Intrapleural Alteplase With Pulmozyme in Pleural Infection Management
ClinicalTrials.gov study NCT04915586. IPD Sharing: NO. Countries: 1. Publications: 1.
Inulin for Infections in the Intensive Care Unit
ClinicalTrials.gov study NCT03865706. IPD Sharing: NO. Countries: 1. Publications: 2.
Trial of 2% Chlorhexidine Bathing on Nosocomial Infections in the Surgical Intensive Care Unit
ClinicalTrials.gov study NCT01640925. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Study of Bathing With Chlorhexidine Impregnated Cloths on Nosocomial Infections in the Pediatric Intensive Care Unit
ClinicalTrials.gov study NCT00549393. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effects of an alternative host on the prevalence and infection intensity of a bumble bee parasite
Open the record for dataset details and reuse information.
Data from: Reduced skin bacterial diversity correlates with increased pathogen infection intensity in an endangered amphibian host
Open the record for dataset details and reuse information.
Data from: Flowering plant composition shapes pathogen infection intensity and reproduction in bumble bee colonies
Open the record for dataset details and reuse information.
Pleiotropic effects of melanin pigmentation: Haemoparasite infection intensity but not telomere length is associated with morph in black sparrowhawks
Open the record for dataset details and reuse information.
Intensity of infection with intracellular Eimeria spp. and pinworms is reduced in hybrid mice compared to parental subspecies
Open the record for dataset details and reuse information.
Data from: Individual consumption of supplemental food as a predictor of reproductive performance and viral infection intensity
1.Supplemental food is often provided to threatened species in order to maintain or enhance reproductive fitness and thus population growth. However, its impact on individual reproductive fitness is rarely evaluated, despite being associated with both positive and negative consequences. 2. We used stable isotope analyses to characterise the relative proportional consumption of supplemental food and quantitative polymerase chain reaction (qPCR) to assess beak and feather disease viral infection intensity among parakeets. Life-history and nest-site data from a long-term monitoring effort was incorporated. 3. Older females benefitted the most from supplemental feeding; demonstrated by a greater reproductive uplift than younger females. There were no strong predictors of viral infection levels among nestlings. 4. Reproductive fitness, measured by the number of fledglings produced per brood, was positively associated with proportional dietary content of supplemental food among adult parakeets and breeding pairs that nested closer to feeding stations consumed more supplemental food than those nesting further away. 5. Synthesis and applications. Our study demonstrates that supplementary feeding can lead to an overall increase in population growth. However, by characterising individual consumption, we also reveal subtle patterns of use and differential benefits on reproductive fitness within a population. Manipulating the delivery of supplemental food may help to reduce demand on finite resources or target the proportion of a population that derives the most benefit, but is associated with trade-offs in fecundity. For example the use of, and access to feeding stations could potentially be targeted towards specific individuals or, positioned in the habitats most deficient in native food. However, increasing reproductive fitness in one component of the population may be accompanied by a decrease in another. This knowledge can be incorporated into adaptive management strategies that aim to fulfil specific objectives associated with species recovery and long-term viability as long as the relative importance of each objective is be considered.
Data from: Infection intensity and infectivity of the tick-borne pathogen Borrelia afzelii
The 'trade-off' hypothesis for virulence evolution assumes that between-host transmission rate is a positive and saturating function of pathogen exploitation and virulence, but there are as yet few tests of this assumption, in particular for vector-borne pathogens. Here, I show that the infectivity (probability of transmission) of the tick-borne bacterium Borrelia afzelii from two of its natural rodent hosts (bank vole and yellow-necked mouse) to its main tick vector increases asymptotically with increasing exploitation (measured as bacterial load in skin biopsies). Hence, this result provides support for one of the basic assumptions of the 'trade-off hypothesis'. Moreover, there was no difference in infectivity between bank voles and yellow-necked mice despite bacterial loads being on average an order of magnitude higher in bank voles, most likely because ticks took larger blood meals from mice. This shows that interspecific variation in host resistance does not necessarily translate into a difference in infectivity.
NEUMOBACT checklist about infection-prevention performance of intensive care nurses in simulation-based scenarios
<p>To design, develop and validate a new tool, called NEUMOBACT, to evaluate critical care nurses' knowledge and skills in ventilator-associated pneumonia (VAP) and catheter-related bacteraemia (CRB) prevention through simulation scenarios involving central venous catheter (CVC), endotracheal suctioning (ETS) and mechanically ventilated patient care (PC) stations.</p>
Chikungunya intra-vector infection dynamics in a French Aedes albopictus population reveals low vector barrier intensity and supports an explosive epidemic potential
<p>Arbovirus emergence and epidemic potential, as approximated by the vectorial capacity formula, depends on host and vector parameters, including the vector’s intrinsic ability to replicate then transmit the pathogen known as vector competence. Vector competence is a complex, time-dependent, quantitative phenotype influenced by biotic and abiotic factors. A combination of experimental and modelling approaches is required to assess arbovirus intra-vector dynamics and estimate its epidemic potential. In this study, we measured infection, dissemination, and transmission dynamics of chikungunya virus (CHIKV) in a field-derived <em>Aedes albopictus</em> population (Lyon metropolis, France) after oral exposure to a range of virus doses spanning human viraemia. Statistical modelling indicates rapid and efficient CHIKV progression in the vector mainly due to an absence of a dissemination barrier, with 100% of the infected mosquitoes ultimately exhibiting a disseminated infection, regardless of the virus dose. Transmission rate data revealed a time-dependent, but overall weak, transmission barrier, with individuals transmitting as soon as 2 days post-exposure (dpe) and >50% infectious mosquitoes at 6 dpe for the highest dose. Based on these experimental intra-vector dynamics data, epidemiological simulations conducted with an agent-based model showed that even at low mosquito biting rates, CHIKV could trigger explosive outbreaks. Together, this reveals the high epidemic potential of CHIKV upon transmission by <em>Aedes albopictus</em> in mainland France.</p>
Respiratory Syncytial Virus Infection in Neonatal Intensive Care Units Throughout Turkey: Prospective Multicenter Study (TurkNICU-RSV Trial)
ClinicalTrials.gov study NCT01915394. IPD Sharing: Not stated. Countries: 1. Publications: 3.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.