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81 results for “inflammation suppression”
Designer high-density lipoprotein particles enhance endothelial barrier function and suppress inflammation
<p>High-density lipoprotein (HDL) nanoparticles promote endothelial cell (EC) function and suppress inflammation, but their utility in treating EC dysfunction has not been fully explored. Here, we describe a fusion protein named ApoA1-ApoM (A1M) consisting of apolipoprotein A1 (ApoA1), the principal structural protein of HDL that forms lipid nanoparticles, and ApoM, a chaperone for the bioactive lipid sphingosine 1-phosphate (S1P). A1M forms HDL-like particles, binds S1P, and is signaling competent. Molecular dynamic simulations showed that the S1P-bound ApoM moiety in A1M efficiently activated the EC surface receptors. Treatment of human umbilical vein endothelial cells (HUVECs) with A1M-S1P stimulated barrier function either alone or cooperatively with other barrier-enhancing molecules, including the stable prostacyclin analog iloprost, and suppressed cytokine-induced inflammation. A1M-S1P injection into mice during sterile inflammation suppressed neutrophil influx and inflammatory mediator secretion. Moreover, systemic A1M administration led to a sustained increase in circulating HDL-bound S1P and suppressed inflammation in a murine model of LPS-induced endotoxemia. We propose that A1M administration may enhance vascular endothelial barrier function, suppress cytokine storm, and promote resilience of the vascular endothelium.</p>
Data from: Docosahexaenoic acid intake suppresses acute silica-induced inflammation, autoantibody production, and autoimmune-related gene expression in lupus-prone mice
<p class="MsoNormal">Short-term repeated intranasal exposure crystalline silica (cSiO<sub>2</sub>), a known human autoimmune trigger, induces uncontrolled inflammation, upregulated IFN-stimulated gene expression, diverse autoantibody production, and glomerulonephritis in lupus-prone female NZBWF1 mice. Dietary supplementation with the omega-3 fatty acid docosahexaenoic acid (DHA) prevents subchronic cSiO<sub>2</sub> triggering of these lupus hallmarks. To understand how this intervention impacts acute effects of cSiO<sub>2</sub>, we fed NZBWF1 mice control (CON) or DHA-containing diet, subjected them to a single acute intranasal instillation of 2.5 mg cSiO<sub>2</sub>, then compared pulmonary inflammatory/autoimmune responses and autoimmune-related gene expression in experimental cohorts terminated at 7 and 28 d post-instillation (PI). Acute cSiO<sub>2 </sub>exposure of CON-fed mice elicited decreased macrophage and increased neutrophil numbers at 7 d PI, whereas at 28 d PI, CON-fed mice treated with particle displayed elevated total cell, macrophage, neutrophil, and lymphocyte counts. In contrast, DHA-fed mice treated with cSiO<sub>2</sub> exhibited less macrophage loss at 7 d PI and reduced total cell, macrophage, and lymphocyte accumulation at 28 d PI. Terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) of lung sections suggested that cSiO<sub>2</sub> induced more robust cell death at 7 d PI in CON-fed than DHA-fed mice. Targeted multiplex ELISA of lung extracts showed that at 28 d PI, cSiO<sub>2</sub> induced higher concentrations of inflammation-associated cytokines (IL-1α, IL-6, and GM-CSF) and IFN-stimulated chemokines (CCL2, CCL3, CXCL10) in the CON-fed cohort than in the DHA-fed cohort. Autoantigen protein microarray of BALF collected at 28 d PI indicated that cSiO<sub>2</sub> induced higher autoantibody responses for representative nuclear, ribosomal, mitochondrial, and complement proteins in CON-fed mice than DHA-fed mice. Gene expression analyses with NanoString Autoimmune Gene Expression assay revealed greater cSiO<sub>2</sub>-triggered upregulation of genes associated with TLR activation, DNA signaling, proinflammatory cytokines, chemokines, type 1 and 2 IFN response signatures, lymphocyte trafficking, MHC class 1 antigen presentation, B and T cell activation at 7 and 28 d PI in CON-fed mice than those fed DHA. Ingenuity Pathway Analysis (IPA) further demonstrated that DHA supplementation quelled cSiO<sub>2</sub>-induced responses top upstream regulators of proinflammatory and IFN-regulated gene networks to observed in CON-fed mice. Altogether, this short-term model illustrated that DHA suppression of aberrant acute cSiO<sub>2</sub>-induced inflammation is linked to altered regulation of autoimmune-related gene expression in lupus-prone mice.</p>
Designer high-density lipoprotein particles enhance endothelial barrier function and suppress inflammation
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IL-3 receptor signaling suppresses chronic intestinal inflammation by controlling mechanobiology and tissue egress of regulatory T cells
<p>RNA from unchallenged mouse <em>Il3r</em><sup>-/-</sup> and <em>Il3r</em><sup>+/+</sup> thymocytes was isolated with the NucleoSpin RNA Kit for RNA isolation (Machery Nagel). RNA-Analysis and sequencing was performed by the Core unit next generation sequencing of the University Hospital Erlangen. The quality of isolated RNA was determined using an Agilent 2100 bioanalyzer with RNA 6000 Nano kit and related software (Agilent). Sequencing libraries were generated from RNA samples using the TruSeq Stranded mRNA Kit (Illumina). Libraries were sequenced on a HiSeq 2500 platform (Illumina). The reads were aligned with Star v2.5.4b against the GRCm38 reference genome. Reads were counted with featureCounts of the Rsubread package v2.8.1.</p>
Fig. 8. Forrestline F suppressed LPSinduced inflammatory activity through Nrf2 in Diterpenoid alkaloids from Delphinium forrestii var. viride and their anti-inflammation activity
Fig. 8. Forrestline F suppressed LPSinduced inflammatory activity through Nrf2 pathways and promoted the LPSinduced nuclear translocation of Nrf2. (A–B) The cells were exposed to forrestline F (5, 10, 20 μM) for 3 h and cultured with LPS for 24 h, except for the control group. The protein expression of Keap-1/Nrf2 pathway was determined by western blotting and the quantifications of protein expression were performed by Image J. (C) The inhibitory effect of forrestline F (20 μM) on the nuclear translocation of Nrf2 induced by LPS via confocal laser scanning microscopy, in conjunction with nuclear DAPI stain (scale bar: 50 μM). The values are presented as mean ± SD of three independent experiments, n = 3. ###p <0.001, vs. the control group; ***p <0.001, vs. LPS-stimulated group.
Colchicine to Suppress Inflammation and Improve Insulin Resistance in Adults and Adolescents With Obesity
ClinicalTrials.gov study NCT05017571. IPD Sharing: YES. Countries: 1. Publications: 3.
Does Extra-fine Hydrofluoroalkane-beclomethasone Dipropionate (HFA-BDP) Suppress Small Airways Inflammation in Chronic Obstructive Pulmonary Disease (COPD)?
ClinicalTrials.gov study NCT00921921. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Testing of HIV Protease Inhibitors to Suppress Inflammation and Improve Cardio Pulmonary Hemodynamics in Subjects With Pulmonary Arterial Hypertension
ClinicalTrials.gov study NCT02023450. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Does Intensive Acid Suppression Reduce Esophageal Inflammation and Recurrent Barrett's Esophagus Following Ablation?
ClinicalTrials.gov study NCT01093755. IPD Sharing: NO. Countries: 1. Publications: 0.
Polyopes affinis Suppressed IFN-γ- and TNF-α-Induced Inflammation in Human Keratinocytes via Down-Regulation of the NF-κB and STAT1 Pathways
GEO Series GSE270435. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Sg SCS suppresses inflammation and oral microbiome
GEO Series GSE211078. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Glucocorticoids and androgens suppress group 2 innate lymphoid cell activation and protect from pathogenic gastric inflammation and metaplasia
GEO Series GSE147177. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
C9orf72 in myeloid cells suppresses STING-induced inflammation
GEO Series GSE151936. Homo sapiens; Mus musculus. 87 samples. Type: Expression profiling by high throughput sequencing.
The 11q13.5 immune disease risk locus contains a distal enhancer required for Treg-mediated suppression of gut inflammation [RNA-Seq]
GEO Series GSE128198. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Critical Role of Synovial Tissue-resident Macrophage Niche in Joint Homeostasis and Suppression of Chronic Inflammation
GEO Series GSE158446. Mus musculus. 39 samples. Type: Expression profiling by high throughput sequencing.
SENP1 prevents steatohepatitis by suppressing RIPK1-driven apoptosis and inflammation
GEO Series GSE193509. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
Deletion of Bmal1 in Intestinal Epithelium Protects against Colonic Inflammation by Suppressing the Apoptosis Pathway
GEO Series GSE271174. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Cardio-immune Interaction via a Clusterin-TLR4 Axis Suppresses Inflammation and Triggers Regeneration
GEO Series GSE307310. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
TBK1 suppresses RIPK1-driven apoptosis and inflammation during development and in aging
GEO Series GSE116613. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Itaconate suppresses atherosclerosis by impeding inflammation through Nrf2 signaling
GEO Series GSE235749. Mus musculus. 9 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.