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2,236 results for “inhalation”
Dataset related to the manuscript entitled "Inhalation with Vitamin D3 Metabolites - A Novel Strategy to Restore Vitamin D3 Deficiencies in Lung Tissue"
<p><strong>The dataset contains the results presented in the manuscript entitled "Inhalation with Vitamin D3 Metabolites - A Novel Strategy to Restore Vitamin D3 Deficiencies in Lung Tissue" Appl. Sci. 2023, 13, 10672. </strong></p><p> </p><p>The presented dataset contains the results of the implementation of the following research project: </p><p><i>Project title</i><strong>:</strong> "Assessment of the possibility of using vitamin D3 in the prevention and treatment of pulmonary fibrosis in the course of hypersensitivity pneumonitis - <i>in vivo</i> studies"</p><p><i>Founder</i><strong>: </strong>National Scientific Center, Poland</p><p><i>Project number</i><strong>:</strong> UMO-2020/38/E/NZ7/00366</p><p><i>Principal Investigator</i>: Marta Kinga Lemieszek</p><p><i>Main investigators:</i><strong> </strong>Michał Chojnacki, Jakub Anisiewicz, Ilona Leśniowska</p><p><i>Place of project implementation</i><strong>:</strong> Department of Medical Biology, Institute of Rural Health, Jaczewskiego 2, 20-090 Lublin, Poland</p>
Raw Data for the article: Donor Preconditioning with Inhaled Sevoflurane Mitigates the Effects of Ischemia-Reperfusion Injury in a Swine Model of Lung Transplantation
<p>Primary graft dysfunction (PGD) and ischemia-reperfusion injury (IRI) occur in up to 30% of patients undergoing lung transplantation and may impact on the clinical outcome. Several strategies for the prevention and treatment of PGD have been proposed, but with limited use in clinical practice. In this study, we investigate the potential application of sevoflurane (SEV) preconditioning to mitigate IRI after lung transplantation. The study included two groups of swines (preconditioned and not preconditioned with SEV) undergoing left lung transplantation after 24-hour of cold ischemia. Recipients' data was collected for 6 hours after reperfusion. Outcome analysis included assessment of ventilatory, hemodynamic, and hemogasanalytic parameters, evaluation of cellularity and cytokines in BAL samples, and histological analysis of tissue samples. Hemogasanalytic, hemodynamic, and respiratory parameters were significantly favorable, and the histological score showed less inflammatory and fibrotic injury in animals receiving SEV treatment. BAL cellular and cytokine profiling showed an anti-inflammatory pattern in animals receiving SEV compared to controls. In a swine model of lung transplantation after prolonged cold ischemia, SEV showed to mitigate the adverse effects of ischemia/reperfusion and to improve animal survival. Given the low cost and easy applicability, the administration of SEV in lung donors may be more extensively explored in clinical practice.</p>
The Upper-Airway Microbiome as a Biomarker of Asthma Exacerbations despite Inhaled Corticosteroid Treatment
<p>The response to inhaled corticosteroids (ICS) in asthma is affected by the interplay of several factors. Among these, the role of the upper-airway microbiome has been scarcely investigated. We aimed to evaluate the association between the salivary, pharyngeal, and nasal microbiome with asthma exacerbations despite ICS use. Samples from 250 asthma patients from the Genomics and Metagenomics of Asthma Severity (GEMAS) study treated with ICS were analyzed. Controls/cases were defined by the absence/presence of asthma exacerbations in the past six months despite being treated with ICS. The bacterial microbiota was profiled by sequencing the V3-V4 region of the 16S rRNA gene. Differences between groups were assessed by PERMANOVA and regression models adjusted for potential confounders. A false discovery rate (FDR) of 5% was used to correct for multiple comparisons. Classification models of asthma exacerbations despite ICS treatment were built with machine learning approaches based on clinical, genetic, and microbiome data. In nasal and saliva samples, cases had lower bacterial diversity (Richness, Shannon, and Faith indexes) than controls (0.007≤p≤0.037). Asthma exacerbations accounted for 8-9% of the interindividual variation of the salivary and nasal microbiomes (0.003≤p≤0.046). Three, four, and eleven bacterial genera from the salivary, pharyngeal, and nasal microbiomes were differentially abundant between groups (4.09x10<sup>-12</sup>≤FDR≤0.047). Integrating clinical, genetic, and microbiome data showed good discrimination for the development of asthma exacerbations despite ICS use (AUC<sub>training</sub>:0.82 and AUC<sub>validation</sub>:0.77). The diversity and composition of the upper-airway microbiome are associated with asthma exacerbations despite ICS treatment. The salivary microbiome has a potential application as a biomarker of asthma exacerbations despite ICS use.</p> <p>The summary results of the association between bacterial genera and asthma exacerbations despite ICS use are published in this repository. Analyses were conducted using the DESeq2 package adjusting for potential confounders (see more details in the manuscript). The submitted summary tables contains the following columns:</p> <ul> <li>Kingdom: Taxonomic classification at Kingdom level</li> <li>Phylum: Taxonomic classification at Phylum level</li> <li>Class: Taxonomic classification at Class level</li> <li>Order: Taxonomic classification at Order level</li> <li>Family: Taxonomic classification at Family level</li> <li>Genus: Taxonomic classification at Genus level</li> <li>log2FC: log<sub>2</sub>(fold-change). Positive values indicate higher abundance in cases and negative values in controls</li> <li>SE: standard error of log<sub>2</sub>(fold-change)</li> <li>P.Value: p-value of the regression model</li> <li>FDR: adjusted p-value by false discovery rate (Benjamin-Hochberg method)</li> </ul>
Рис. 2. Laternula elliptica: А – раковина вЗрослого моллюска иЗ морЯ Дейвиса, L=87 мм, вид сбоку; Б – вид с дорсальной стороны (по: Егорова [1982]); В – расположение пустых раковин Laternula elliptica в осыпаюЩемсЯ песчаном грунте на склоне подводного холма (по рисунку иЗ полевого дневника Б.И. Сиренко, ЗИН РАН); Г – наружные отверстиЯ вводного и выводного сифонов Laternula elliptica (King, 1832) на поверхности грунта. Fig. 2. Laternula elliptica: А – shell of adult mollusc from the Davis Sea, L=87 mm, lateral view; Б – dorsal view (after: Егорова [1982]); В – empty shells of Laternula elliptica in friable sand on a slope of underwater hill (after sketch in the field journal of Dr. B.I. Sirenko, Zool. Inst. RAS); Г – external openings of inhalant and exhalant siphons of Laternula elliptica on surface of bottom deposits. in Species of warm-water origin Laternula elliptica (King, 1832) (Mollusca: Bivalvia: Laternulidae), a widespread mollusk in recent Antarctica
Рис. 2. Laternula elliptica: А – раковина вЗрослого моллюска иЗ морЯ Дейвиса, L=87 мм, вид сбоку; Б – вид с дорсальной стороны (по: Егорова [1982]); В – расположение пустых раковин Laternula elliptica в осыпаюЩемсЯ песчаном грунте на склоне подводного холма (по рисунку иЗ полевого дневника Б.И. Сиренко, ЗИН РАН); Г – наружные отверстиЯ вводного и выводного сифонов Laternula elliptica (King, 1832) на поверхности грунта. Fig. 2. Laternula elliptica: А – shell of adult mollusc from the Davis Sea, L=87 mm, lateral view; Б – dorsal view (after: Егорова [1982]); В – empty shells of Laternula elliptica in friable sand on a slope of underwater hill (after sketch in the field journal of Dr. B.I. Sirenko, Zool. Inst. RAS); Г – external openings of inhalant and exhalant siphons of Laternula elliptica on surface of bottom deposits.
Resuspension of Inhalable Particles from Clothing: A Manikin-Based Chamber Study
<p>These data are part of the study 'Resuspension of Inhalable Particles from Human Clothing: A Manikin-Based Chamber Study.'</p> <p>The videos of a thermal manikin performing upper body movements at 0.25 Hz, 0.5 Hz, and 0.75 Hz, corresponding to experimental IDs 1, 2, and 3.</p>
Human Genetics Influences Microbiome Composition Involved in Asthma Exacerbations despite Inhaled Corticosteroid Treatment
<p>Additional Supplement Data of the manuscript Perez-Garcia J, Espuela-Ortiz A, Hernández-Pérez JM, et al. Human Genetics Influences Microbiome Composition Involved in Asthma Exacerbations despite Inhaled Corticosteroid Treatment (in press). <em>J Allergy Clin Immunol</em>. 2023;S0091-6749(23)00748-0. doi:10.1016/j.jaci.2023.05.021.</p> <p>This Supplement Data contains the following items:</p> <table> <tbody> <tr> <td>Additional Table 1</td> <td>List of independent mbQTLs associated with p<1x10<sup>-5</sup> in the mbGWAS from saliva samples in Europeans (discovery).</td> </tr> <tr> <td>Additional Table 2</td> <td>List of independent mbQTLs associated with p<1x10<sup>-5</sup> in the mbGWAS from pharyngeal samples in Europeans (discovery).</td> </tr> <tr> <td>Additional Table 3</td> <td>List of independent mbQTLs associated with p<1x10<sup>-5</sup> in the mbGWAS from nasal samples in Europeans (discovery).</td> </tr> <tr> <td>Additional Table 4</td> <td>Summary results of enrichment analyses using the Enrichr platform.</td> </tr> <tr> <td>Additional Table 5</td> <td>Summary results of stratified enrichment analyses by biological sample type.</td> </tr> <tr> <td>Additional Table 6</td> <td>List of independent mbQTLs associated with p<1x10<sup>-5</sup> in the mbGWAS from saliva samples in African Americans (replication phase).</td> </tr> <tr> <td>Additional Table 7</td> <td>List of independent mbQTLs associated with p<1x10<sup>-5</sup> in the mbGWAS from saliva samples in Latinos (replication phase).</td> </tr> <tr> <td>Additional Table 8</td> <td>Summary results of replication enrichment analyses in saliva samples.</td> </tr> <tr> <td>Additional Table 9</td> <td>Summary statistics of the mbQTL analysis of <em>Streptococcus</em> in nasal samples.</td> </tr> <tr> <td>Additional Table 10</td> <td>Summary statistics of the mbQTL analysis of <em>Campylobacter</em> in pharyngeal samples.</td> </tr> <tr> <td>Additional Table 11</td> <td>Summary statistics of the mbQTL analysis of <em>Tannerella</em> in pharyngeal samples.</td> </tr> <tr> <td>Additional Table 12</td> <td>Summary table of the different genetic models tested for each mbQTL pair.</td> </tr> </tbody> </table>
Study of Drug Exposure in Systemic Circulation of Primatene Mist by Oral Inhalation, Versus Epinephrine Injection by Intramuscular Injection and ProAir by Oral Inhalation in Healthy Individuals
ClinicalTrials.gov study NCT04207840. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Efficacy and Safety Evaluation of Budesonide/Formoterol SPIROMAX® Inhalation Powder Versus SYMBICORT® TURBOHALER®
ClinicalTrials.gov study NCT01803555. IPD Sharing: YES. Countries: 16. Publications: 1.
Inhaled Oxytocin and HPA Axis Reactivity
ClinicalTrials.gov study NCT03593473. IPD Sharing: YES. Countries: 1. Publications: 1.
Efficacy and Safety of Indacaterol Acetate Delivered Via the Concept1 Inhalation Device in Children Greater or Equal to 6 and Less Than 12 Years of Age With Asthma
ClinicalTrials.gov study NCT02892019. IPD Sharing: UNDECIDED. Countries: 11. Publications: 1.
Dose-finding Study to Assess the Efficacy, Safety and Tolerability of Tobramycin Inhalation Powder in Patients With Non-Cystic Fibrosis Bronchiectasis and Pulmonary P. Aeruginosa Infection
ClinicalTrials.gov study NCT02712983. IPD Sharing: YES. Countries: 6. Publications: 2.
Data from 90-day quantitative inhalation toxicology study evaluating the dose-response and fate in the lung and pleura of chrysotile-containing brake dust
<p>The final results from this multi-dose, 90-day inhalation toxicology study in the rat with life-time post-exposure observation have shown a significant fundamental difference in pathological response and tumorgenicity between brake dust generated from brake pads manufactured with chrysotile or from chrysotile alone in comparison to the amphiboles, crocidolite and amosite asbestos.</p> <p>The groups exposed to brake dust showed no significant pathological or tumorigenic response in the respiratory track compared to the air control group at exposure concentrations and deposited doses well above those at which humans have been exposed. Slight alveolar/interstitial macrophage accumulation of particles was noted. Wagner grades were 1–2 (1 = control group), similar to the TiO2 particle control group. Chrysotile was not biopersistent, exhibiting in the lung a deterioration of its matrix which results in breakage into particles and short fibers which can be cleared by alveolar macrophages and which can continue to dissolve. Particle-laden macrophage accumulation was observed, leading to a very-slight interstitial inflammatory response (Wagner grade 1–3). There was no peribronchiolar inflammation, occasional very-slight interstitial fibrosis (Wagner grade 4), and no exposure-related tumorigenic response.</p> <p>The pathological response of crocidolite and amosite compared to the brake dust and chrysotile was clearly differentiated by the histopathology and the confocal analysis. Crocidolite and amosite induced persistent inflammation, microgranulomas, persistent fibrosis (Wagner grades 4), and a dose-related lung tumor response. Confocal microscopy quantified extensive inflammatory response and collagen development in the lung, visceral and parietal pleura as well as pleural adhesions.</p> <p>These results provide a clear foundation for differentiating the innocuous effects of brake dust exposure from the adverse effects following amphibole asbestos exposure.</p>
Dataset underpinning the development of a PBK model for inhalation of TiO2 NPs in rats
<table> <tbody> <tr> <td> <p>This dataset contains concentration-time profiles (expressed as % of the initial dose) of 20 nm TiO2 nanoparticles following a 2-hour inhalation experiment in rats, with tissue and excreta samples taken over a period of 28 days post exposure. The data were extracted from the publication of Kreyling et al. (2019) (<a href="https://doi.org/10.1186/s12989-019-0303-7">https://doi.org/10.1186/s12989-019-0303-7</a>) </p> <p> </p> <p> </p> </td> </tr> </tbody> </table>
Inspiratory Flow Rates Achieved by the COPD Patients Through Breezhaler®, Ellipta® and Handihaler® Inhaler Devices
ClinicalTrials.gov study NCT02596009. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Clinical Investigation Into Inhaled Treprostinil Sodium in Patients With Severe Pulmonary Arterial Hypertension (PAH)
ClinicalTrials.gov study NCT00147199. IPD Sharing: Not stated. Countries: 10. Publications: 1.
A Clinical Study Assessing Critical Errors, Training/Teaching Time, and Preference Attributes of the ELLIPTA® Dry Powder Inhaler, in Comparison to Combinations of Dry Powder Inhalers Used to Provide T
ClinicalTrials.gov study NCT02982187. IPD Sharing: NO. Countries: 2. Publications: 1.
Long Term Administration of Inhaled Mannitol in Cystic Fibrosis
ClinicalTrials.gov study NCT00630812. IPD Sharing: Not stated. Countries: 7. Publications: 11.
The Study is Enrolling Kids From 8 to 17 Years Old. The BreathSmart Device Attaches to the Inhaler to Measure Adherence.
ClinicalTrials.gov study NCT03734861. IPD Sharing: NO. Countries: 1. Publications: 2.
Cyclosporine Inhalation Solution (CIS) in Lung Transplant and Hematopoietic Stem Cell Transplant Recipients for the Treatment of Bronchiolitis Obliterans Syndrome
ClinicalTrials.gov study NCT01287078. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Inflammatory Indices in Predicting the Failure of Inhaled Corticosteroids Reduction in Young Participants With Asthma
ClinicalTrials.gov study NCT03788057. IPD Sharing: NO. Countries: 1. Publications: 11.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.