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27 results for “insulin-like growth factor-1”
Data from: Compensatory growth is accompanied by changes in insulin-like growth factor-1 but not markers of cellular aging in a long-lived seabird
<p>Developing organisms often plastically modify growth in response to environmental circumstances, which may be adaptive, but is expected to entail long-term costs. However, the mechanisms that mediate these growth adjustments and any associated costs are less well understood. In vertebrates, one mechanism that may be important in this context is the highly conserved signaling factor insulin-like growth factor-1 (IGF-1), which is often positively related to post-natal growth and negatively related to longevity. To test this idea, we exposed captive Franklin's gulls (<em>Leucophaeus</em> <em>pipixcan</em>) to a physiologically relevant nutritional stressor by restricting food availability during post-natal development and examined the effects on growth, IGF-1, and two potential biomarkers of cellular and organismal aging (oxidative stress, and telomeres). During food restriction, experimental chicks gained body mass more slowly and had lower IGF-1 levels than controls. Following the food restriction, experimental chicks underwent compensatory growth, which was accompanied by an increase in IGF-1 levels. Interestingly however, there were no significant effects of the experimental treatment or of variation in IGF-1 levels on oxidative stress or telomeres. These findings suggest that IGF-1 is responsive to changes in resource availability but is not associated with increased markers of cellular aging during development in this relatively long-lived species.</p>
Effects of SomatoKine (Iplex)Recombinant Human Insulin-like Growth Factor-1/Recombinant Human Insulin-like Growth Factor-binding Protein-3 (rhIGF-I/rhIGFBP-3) in Myotonic Dystrophy Type 1 (DM1)
ClinicalTrials.gov study NCT00233519. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Pilot Treatment Study of Insulin-Like Growth Factor-1 (IGF-1) in Autism Spectrum Disorder
ClinicalTrials.gov study NCT01970345. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Insulin-like Growth Factor-1 in Amyotrophic Lateral Sclerosis (ALS) Trial
ClinicalTrials.gov study NCT00035815. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Treatment for Growth Failure in Patients With X-Linked Severe Combined Immunodeficiency: Phase 2 Study of Insulin-Like Growth Factor-1
ClinicalTrials.gov study NCT00490100. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Data from: Compensatory growth is accompanied by changes in insulin-like growth factor-1 but not markers of cellular aging in a long-lived seabird
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Effect of a High Protein Diet on the 24-hour Profile of Ghrelin, GH (Growth Hormone) and IGF-1 (Insulin-like Growth Factor-1)
ClinicalTrials.gov study NCT00108225. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Global Patient Registry to Monitor Long-term Safety and Effectiveness of Increlex® in Children and Adolescents With Severe Primary Insulin-like Growth Factor-1 Deficiency (SPIGFD).
ClinicalTrials.gov study NCT00903110. IPD Sharing: Not stated. Countries: 11. Publications: 4.
Status of Growth Hormone/ Insulin-like Growth Factor-1 (GH/IGF-1) Axis and Growth Failure in Ataxia Telangiectasia (AT)
ClinicalTrials.gov study NCT01052623. IPD Sharing: Not stated. Countries: 1. Publications: 10.
A 48-Week (24-Week Baseline Followed by a 24-Week Treatment) Phase II Pilot Study of the Tolerability and Effect/Efficacy of Subcutaneously Administered Insulin-Like Growth Factor-1 (rhIGF) (CEP-151)
ClinicalTrials.gov study NCT00001669. IPD Sharing: Not stated. Countries: 1. Publications: 3.
A New Marker for Early Diagnosis of Pneumoperitoneum-Related Acute Kidney Injury: Insulin-Like Growth Factor-1 (IGF-1)
ClinicalTrials.gov study NCT05612802. IPD Sharing: NO. Countries: 1. Publications: 4.
Food restriction delays breeding and affects insulin-like growth factor-1, oxidative damage, and haematocrit value before egg-laying in female canaries
<p>Environmental challenges, such as fluctuations in food availability, could influence reproductive investment. If resource availability is poor, individuals need to decide in which life-history process they invest more energy and vital compounds, which determine the cost of reproduction. In resource allocation, the physiological pathways have important roles. The aim of our study was to examine whether food availability influenced physiological traits (insulin-like growth factor-1 (IGF-1) concentration, antioxidant capacity (OXY), level of oxidative damage (ROM) and haematocrit value) prior to egg-laying in female canaries (<i>Serinus canaria</i>). We also tested whether these physiological traits were associated with traits reflecting the reproductive investment in egg macro- (egg mass and yolk mass) and micronutrient content (eggshell biliverdin- and protoporphyrin-based colouration). To test these questions we conducted a food restriction experiment with control and food-restricted (72% of control food) groups. Our study showed that food-restricted canary females delayed egg-laying and the physiological traits differed between the groups. At the pre-laying period, after 9-11 days of treatment, a reduction in plasma IGF-1 concentration, ROM level, and haematocrit value was detected in the control group, whereas in the food-restricted group plasma IGF-1 concentration increased, while ROM level and haematocrit value did not change. Plasma level of OXY was not influenced by treatment or breeding period. Plasma concentration of IGF-1, haematocrit value and oxidative status before egg laying did not affect the egg characteristics. Our study highlights the importance of breeding stage when studying and interpreting the effects of food restriction on physiological traits of breeding birds. Moreover, our data suggest that nutritional limitation had an effect on the timing of egg-laying that could be mediated by changes in physiological variables.</p>
Growth Hormone Feedback to Insulin-like Growth Factor-I (IGF-1) and Oral Glucose Tolerance Test (OGTT)
ClinicalTrials.gov study NCT00915954. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Recombinant Human Insulin-Like Growth Factor (rhIGF-1) Treatment of Short Stature Associated With IGF-1 Deficiency
ClinicalTrials.gov study NCT00125190. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Prepubertal Children With Growth Failure Associated With Primary Insulin-Like Growth Factor-1 (IGF-1) Deficiency
ClinicalTrials.gov study NCT00125164. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Food restriction delays breeding and affects insulin-like growth factor-1, oxidative damage, and haematocrit value before egg-laying in female canaries
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RIZ1 repression is associated with insulin-like growth factor-1 signaling activation in chronic myeloid leukemia...
GEO Series GSE2243. Homo sapiens. 8 samples. Type: Expression profiling by array.
Selective loss of resident macrophage derived insulin-like growth factor-1 abolishes adaptive cardiac growth to stress
GEO Series GSE179343. Homo sapiens; Mus musculus. 7 samples. Type: Expression profiling by high throughput sequencing.
Circulating insulin-like growth factor (IGF)-1 Regulates Hippocampal IGF-1 Levels and Brain Gene Expression During Adolescence
GEO Series GSE29512. Rattus norvegicus. 24 samples. Type: Expression profiling by array.
Assessment of Nutritional Status and Role of Insulin-like Growth Factor-1 in Children
ClinicalTrials.gov study NCT05529550. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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OpenNeuro
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