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34 results for “interleukin 6”
A Complement Atlas identifies interleukin 6 dependent alternative pathway dysregulation as a key druggable feature of COVID-19.
<p>Improvements in COVID-19 treatments, especially for the critically ill, require deeper understanding of the mechanisms driving disease pathology. The complement system is a crucial component of innate host defense, but can also contribute to tissue injury. Although all complement pathways have been implicated in COVID-19 pathogenesis, the upstream drivers and downstream effects on tissue injury remain poorly defined. We demonstrate that complement activation is primarily mediated by the alternative pathway, and we provide a comprehensive atlas of the complement alterations around the time of respiratory deterioration. Proteomic and single-cell sequencing mapping across cell types and tissues reveals a division of labor between lung epithelial, stromal, and myeloid cells in complement production, in addition to liver-derived factors. We identify IL-6 and STAT1/3 signaling as an upstream driver of complement responses, linking complement dysregulation to approved COVID-19 therapies. Furthermore, an exploratory proteomic study indicates that inhibition of complement C5 decreases epithelial damage and markers of disease severity. Collectively, these results support complement dysregulation as a key druggable feature of COVID-19.</p>
In silico study for screening of natural phytochemicals and metformin as a potential inhibitor of interleukin 6 as target for covid-19
<p>Interleukin 6 is considered the corner stone at treatment of covid-19 specially the severe cases and it is the marker of severe inflammation and the gate of cytokine storm , so the future studies for this important proinflammatory cytokine storm , the first target for speed recovery from sars cov2 it is overcoming this cytokine which is immune response to virus , it is responsible about the fever and most sypmtoms of severity of covid-19 also may has role at smell and taste , so this study target this interleukin-6 by discovering natural potential inhibitors of IL-6. We do molecular docking for some natural phytochemicals like EGCG , bromelain , luteolin , vitexin and isovitexin , in adding to metformin and polyetheylene glycocl </p>
Vitamin D Effect on A Disintegrin-like And Metalloprotease Thrombospondin1 Motif 13& Interleukin 6 in Leukemia
ClinicalTrials.gov study NCT05149339. IPD Sharing: UNDECIDED. Countries: 1. Publications: 7.
Saliva Irisin Level is Higher and Related With Interleukin 6 in Generalized Periodontitis
ClinicalTrials.gov study NCT05474820. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Effect of Simvastatin Versus Calcium Hydroxide Intracanal Medications on Post-operative Pain and Interleukin 6 and 8
ClinicalTrials.gov study NCT05525013. IPD Sharing: NO. Countries: 1. Publications: 2.
Evaluation of Interleukine 6 (and Other Cytokines and Inflammatory Markers) in COVID-19 Patients With a Systemic Inflammatory Response Syndrome
ClinicalTrials.gov study NCT04346017. IPD Sharing: NO. Countries: 1. Publications: 1.
THE VALUE OF INTERLEUKIN 6 AS A DIAGNOSTIC MARKER IN NEONATAL SEPSIS
ClinicalTrials.gov study NCT05585957. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Evaluation of Serum Interleukin 6 and 8 in Children With Acute Gastroenteritis
ClinicalTrials.gov study NCT05213325. IPD Sharing: NO. Countries: 1. Publications: 3.
Effect of Interleukin 6 Receptor Antagonists in SARS-CoV-2 Patients
ClinicalTrials.gov study NCT05367882. IPD Sharing: NO. Countries: 1. Publications: 1.
Fig. 6. X in Guaianolides from Artemisia codonocephala suppress interleukine-1β secretion in macrophages
Fig. 6. X-ray ORTEP drawings of 6‒7.
Clazakizumab (Anti-Interleukin 6 (IL-6) Monoclonal) Compared to Placebo for Coronavirus Disease 2019 (COVID-19)
ClinicalTrials.gov study NCT04348500. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
The Effect of Locally Dilvered Ciprofloxacine Loaded Injectable Platelet-rich Fibrin as an Adjunct to Non-surgical Periodontal Therapy on the Gingival Crevicular Level of Interleukin 6
ClinicalTrials.gov study NCT06968286. IPD Sharing: NO. Countries: 1. Publications: 0.
Gene expression in kidney of interleukin-18 knockout mice at 6 and 12 weeks of age
GEO Series GSE64310. Mus musculus. 12 samples. Type: Expression profiling by array.
Gene expression in brain of interleukin-18 knockout mice at 6 and 12 weeks of age
GEO Series GSE64307. Mus musculus. 12 samples. Type: Expression profiling by array.
Gene expression in liver of interleukin-18 knockout mice at 6 and 12 weeks of age
GEO Series GSE64309. Mus musculus. 12 samples. Type: Expression profiling by array.
Gene expression in brown adipose tissue of interleukin-18 knockout mice at 6 and 12 weeks of age
GEO Series GSE64308. Mus musculus. 12 samples. Type: Expression profiling by array.
Comparison Between Effect of Vitamin D Versus Dexmedetomidine in Patients with Head Trauma Using Interleukin 6
ClinicalTrials.gov study NCT06565338. IPD Sharing: NO. Countries: 1. Publications: 0.
Whole Body Vibration Versus Aerobic Training on Interleukin 6 and Endurance After Renal Transplantation
ClinicalTrials.gov study NCT07333105. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Comparison Between Interleukin 6 and Procalcitonin in Detecting Sepsis and Incidence of Mortality in Burn ICU Patients
ClinicalTrials.gov study NCT06915974. IPD Sharing: YES. Countries: 1. Publications: 0.
Music Therapy on Neutrophyl Lymphocytes Ratio, Interleukin 6 and Interleukin 10 Levels of Burnout Syndrome
ClinicalTrials.gov study NCT05750160. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.