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264 results for “interneuron”
nNOS-expressing interneurons control basal and behaviorally evoked arterial dilation in somatosensory cortex of mice
<p>Cortical neural activity is coupled to local arterial diameter and blood flow. However, which neurons control the dynamics of cerebral arteries is not well understood. We dissected the cellular mechanisms controlling the basal diameter and evoked dilation in cortical arteries in awake, head-fixed mice. Locomotion drove robust arterial dilation, increases in gamma band power in the local field potential (LFP), and increases calcium signals in pyramidal and neuronal nitric oxide synthase (nNOS)-expressing neurons. Chemogenetic or pharmocological modulation of overall neural activity up or down caused corresponding increases or decreases in basal arterial diameter. Modulation of pyramidal neuron activity alone had little effect on basal or evoked arterial dilation, despite pronounced changes in the LFP. Modulation of the activity of nNOS-expressing neurons drove changes in the basal and evoked arterial diameter without corresponding changes in population neural activity.</p>
Molecular and electrophysiological features of GABAergic neurons in the dentate gyrus reveal limited homology with cortical interneurons
<p>GABAergic interneurons tend to diversify into similar classes across telencephalic regions. However, it remains unclear whether the electrophysiological and molecular properties commonly used to define these classes are discriminant in the hilus of the dentate gyrus. Here, using patch-clamp combined with single cell RT-PCR, we compare the relevance of commonly used electrophysiological and molecular features for the clustering of GABAergic interneurons sampled from the mouse hilus and primary sensory cortex. While unsupervised clustering groups cortical interneurons into well-established classes, it fails to provide a convincing partition of hilar interneurons. Statistical analysis based on resampling indicates that hilar and cortical GABAergic interneurons share limited homology. While our results do not invalidate the use of classical molecular marker in the hilus, they indicate that classes of hilar interneurons defined by the expression of molecular markers do not exhibit strongly discriminating electrophysiological properties.</p>
Fig. 15 in Expression of green fluorescent protein defines a specific population of lamina II excitatory interneurons in the GRP::eGFP mouse
Fig. 15. Trychosis breviterebratus sp. nov. (A-F, KPM-NK 75758) ― A, lateral habitus; B, dorsal habitus; C, frons, frontal view; D, head and mesosoma, lateral view; E, propodeum, dorsal view; F, right wings.
Fig. 14. Hylophasma luica Sheng, Li in Expression of green fluorescent protein defines a specific population of lamina II excitatory interneurons in the GRP::eGFP mouse
Fig. 14. Hylophasma luica Sheng, Li & Wang, 2019 (A-D, KPM-NK 75813; E, KPM-NK 75821) and Picardiella melanoleuca (Gravenhorst, 1829)(F-J, KPM-NK 75744) ― A, E, F, lateral habitus; B, G, dorsal habitus; C, H, head, frontal view; D, J, right fore wing; I, propodeum, dorsal view.
Fig. 13. Hoplocryptus sumiyona Uchida, 1956 in Expression of green fluorescent protein defines a specific population of lamina II excitatory interneurons in the GRP::eGFP mouse
Fig. 13. Hoplocryptus sumiyona Uchida, 1956 (A-C, KPM-NK 76581) and H. toshimensis sp. nov. (E-I, KPM-NK 75797) ― A, E, dorsal habitus; B, F, head, frontal view; C, head and mesosoma, dorso-lateral view; D, lateral habitus; G, propodeum, dorsal view; H, right fore wing; I. metasoma, dorsal view.
Fig. 12 in Expression of green fluorescent protein defines a specific population of lamina II excitatory interneurons in the GRP::eGFP mouse
Fig. 12. Hoplocryptus pini (Momoi, 1973) (A, D, F, KPM-NK 76578; B, E, KPM-NK 75780; C, G, KPM-NK 75774; H-J, 76580) ― A-C, H, lateral habitus; D, E, I, head, mesosoma and metasoma, dorsal view; F, J, head, frontal view; G, propodeum, dorsso-lateral view.
Fig. 10 in Expression of green fluorescent protein defines a specific population of lamina II excitatory interneurons in the GRP::eGFP mouse
Fig. 10. Hoplocryptus ezoensis sp. nov. (A, C-F, KPM-NK 75799; B, KPM-NK 75802) and Ho. intermedius sp. nov. (G-K, KPM-NK 75806; L, M, KPM-NK 76582) ― A, G, L, lateral habitus; B, C, dorsal habitus; D, H, M, head, frontal view; E, J, propodeum, dorsal (E) and dorso-lateral (J) view; I, head and mesoscutum, dorso-lateral view; K, right fore wing.
Fig. 6. Caenocryptoides convergens Momoi, 1966 in Expression of green fluorescent protein defines a specific population of lamina II excitatory interneurons in the GRP::eGFP mouse
Fig. 6. Caenocryptoides convergens Momoi, 1966 (A-C, TMNH) and Cryptus daidaigaster sp. nov. (D-J, NIAES) ― A, D, I, lateral habitus; B, E, head, mesosoma and metasoma, dorso-lateral view; C, F, J, head, frontal view; G, propodeum, dorsal view; H, right wings.
Fig. 2 in Expression of green fluorescent protein defines a specific population of lamina II excitatory interneurons in the GRP::eGFP mouse
Fig. 2. Aritranis kuro sp. nov. (A, B, KPM-NK 75832); Buathra nipponica sp. nov. (C, D, KPM-NK 75746), Glabridorsum japonicum sp. nov. (E, KPM-NK 75742), Hoplocryptus ezoensis sp. nov. (F, KPM-NK 75799), Ho. intermedius sp. nov. (G, KPM-NK 75804), Ho. japonicus sp. nov. (H, KPM-NK 75771), Ho. maculatus sp. nov. (I, KPM-NK 75790, J, KPM-NK 75781, K, KPM-NK 75783), Hylophasma luica Sheng, Li & Wang, 2019 (L, M, KPM-NK 75813) and Trychosis breviterebratus sp. nov. (N, KPM-NK 75748), females ― A, F, G, H, M, propodeum and T I, dorsal (A, H, M) and lateral (F, G) view; B, E, L, T I, lateral view; C, I, propodeum, lateral (C) and dorsal (I) view; D, T I, lateral view; J, K, area basalis and part of anterior transverse carina of propodeum; N, metasoma, lateral view. Surface sculpture of right half of Fig. 2A omitted.
Fig. 1 in Expression of green fluorescent protein defines a specific population of lamina II excitatory interneurons in the GRP::eGFP mouse
Fig. 1. Aritranis kuro sp. nov. (A, KPM-NK 75838); Buathra nipponica sp. nov. (B, C, KPM-NK 75746), Hoplocryptus ezoensis sp. nov. (D, KPM-NK 75799), Ho. ashoroensis sp. nov. (E, NIAES), Ho. intermedius sp. nov. (F, KPM-NK 75804), Ho. japonicus sp. nov. (G, KPM-NK 75771), Ho. maculatus sp. nov. (H, KPM-NK 75781), Ho. toshimensis sp. nov. (I, KPM-NK 75797), Hylophasma luica Sheng, Li & Wang, 2019 (J, K, KPM-NK 75813) and Trychosis breviterebratus sp. nov. (L-P, KPM-NK 75748), females ― A-D, J-M, head, frontal (A, B, D, J, L), lateral (C) and dorsal (K, M) view; E-I, apical margin of clypeus, frontal view; K, left mandible; O, left fore femur, anterior view; lower part of epicnemial carina, lateral view.
Fig. 5 in Expression of green fluorescent protein defines a specific population of lamina II excitatory interneurons in the GRP::eGFP mouse
Fig. 5. Buathra nipponica sp. nov. (A-G, KPM-NK 75746; H, I, KPM-NK 75747) ― A, lateral habitus; B, mesosoma, lateral view; C, head, mesosoma and metasoma, dorsal view; D, frons, frontal view; E, propodeum, dorsal view; F, right fore wing; G, apex of metasoma, dorso-lateral view.
Fig. 9 in Expression of green fluorescent protein defines a specific population of lamina II excitatory interneurons in the GRP::eGFP mouse
Fig. 9. Gotra elegans sp. nov. (A, C, D, KPM-NK 75822; B, E, KPM-NK 75823) and Hoplocryptus ashoroensis sp. nov. (F-J, NIAES) ― A, C, lateral habitus; B, dorsal habitus; C, H, head, frontal view; D, head, mesoscutum and scutellum, dorsal view; E, I, propodeum, dorsal view; J, right fore wing.
Fig. 4. Agrothereutes minousubae Nakanishi, 1965 in Expression of green fluorescent protein defines a specific population of lamina II excitatory interneurons in the GRP::eGFP mouse
Fig. 4. Agrothereutes minousubae Nakanishi, 1965 (A, B, KPM-NK 76585; C, D, KPM-NK 76590) and Aritranis kuro sp. nov. (E, G, I, KPM-NK 75824; F, H, KPM-NK 75825; J, K, KPM-NK 76577) ― A, C, E, J, lateral habitus; B, tegula and humeral plate (red arrow), dorso-lateral view; D, G, K, head, frontal view; F, dorsal habitus; H, propodeum, dorsal view; I, right wings.
Fig. 7. Gambrus homonae Sonan, 1930 in Expression of green fluorescent protein defines a specific population of lamina II excitatory interneurons in the GRP::eGFP mouse
Fig. 7. Gambrus homonae Sonan, 1930 (A, KPM-NK 76572; B-D, 76568; E, KPM-NK 76573) ― A, E, lateral habitus; B, head, frontal view; C, propodeum, dorsal view; D, right fore wing.
Fig. 3 in Expression of green fluorescent protein defines a specific population of lamina II excitatory interneurons in the GRP::eGFP mouse
Fig. 3. Aritranis kuro sp. nov. (A, KPM-NK 75838), Buathra nipponica sp. nov. (B, KPM-NK 75746), Cryptus daidaigaster sp. nov. (C, NIAES), Gambrus homonae Sonan, 1930 (D, KPM-NK 76566); Glabridorsum japonicum sp. nov. (E, KPM-NK 75742), Gotra elegans sp. nov. (F, KPM-NK 75822); Hoplocryptus ashoroensis sp. nov. (G, NIAES), Ho. ezoensis sp. nov. (H, KPM-NK 75800), Ho. intermedius sp. nov. (I, KPM-NK 75804), Ho. japonicus sp. nov. (J, KPM-NK 75771), Ho. maculatus sp. nov. (K, KPM-NK 75781), Ho. pini (L, KPM-NK 76579), Ho. toshimensis sp. nov. (M, KPM-NK 75797), Picardiella melanoleuca (Gravenhorst, 1829) (N, KPM-NK 75744) and Trychosis breviterebratus sp. nov. (N, KPM-NK 75758), apex of ovipositor, lateral view.
Fig. 8 in Expression of green fluorescent protein defines a specific population of lamina II excitatory interneurons in the GRP::eGFP mouse
Fig. 8. Glabridorsum japonicum sp. nov. (A, C, E, G, KPM-NK 75742; B, D, F, KPM-NK 75743) ― A, lateral habitus; B, head, mesosoma and metasoma, dorsal view; C, D, mesosoma, lateral view; E, head, frontal view; F, propodeum, dorsal view; G, apical part of right fore wing.
Data of "Thalamic drive of cortical parvalbumin-positive interneurons during down-states in anesthetized mice"
<p>This dataset and relative code support the scientific article "Thalamic drive of cortical parvalbumin-positive interneurons during down-states in anesthetized mice" by the same authors accepted for publication in Current Biology (2019).</p> <p>For further detail, please refer to README.txt.</p>
Set of Data from "Selective targeting of striatal parvalbumin-expressing interneurons for transgene delivery" https://doi.org/10.1016/j.jneumeth.2021.109105
<p>PV<sup>Cre</sup> (+/+) mice were injected in the right striatum with AAV2/1-hsyn-FLEX-eGFP AAV2/9-CBA-FLEX-eGFP or AAV2/9-hsyn-FLEX-eGFP vectors. Two weeks after, cells were manually counted by a blind observer on 2D maximal intensity projections of confocal images transformed into the tiff format using the Multi-point tool in ImageJ. The GraphPad .pzfx files show the quantitative anaylsis of the proportion of GFP+ cells which were PV+ (specificty) , the proportion of PV+ cells which were GFP+ (efficiency), the proportion of PV+ cells in the injected striatum relative to to the injected striatum of PV<sup>Cre</sup> (+/+) mice (absence of vector toxicity) and the proportion of PV+ cells in the striatum of PV<sup>Cre</sup> (+/+) mice versus wt mice.</p> <p> </p>
Simulation of ripple oscillations in a large interneuron network under different levels of constant external drive
<p>Example simulation to be used with code on GitHub repository: https://github.com/NatalieSchieferstein/interneuron_ripples_with_ifa.git .</p><p>Simulation data was generated using pypet (pypet.readthedocs.io/) and Brian2.</p><p>Code and simulation data are Supplement to publication: 10.1101/2023.01.30.526209 .</p><p> </p>
Molecular and electrophysiological features of GABAergic neurons in the dentate gyrus reveal limited homology with cortical interneurons
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