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3 results for “intracellular environment”
Importance of melanin-based colouration and environment in shaping intracellular glutathione levels in nestling and adult tawny owls (Strix aluco)
<p>Resources allocated in reproduction are traded off against those invested in self-maintenance such as antioxidant response. Glutathione (GSH) is an intracellular antioxidant defence that scavenges reactive oxygen species, the deleterious byproducts of oxygen consumption. Given the role of intracellular GSH in pheomelanogenesis, a trade-off in GSH allocation between resistance to oxidative stress and melanin production may take place. To investigate how intracellular GSH is regulated in differently coloured individuals at the time of reproduction (in adults) and of intense melanogenesis (in nestlings), we measured the total pool of GSH produced ( t GSH), consumed (oxGSH) and available (redGSH) in adult tawny owls and their offspring which were cross-fostered between randomly chosen nests. Our goal was to describe potential correlations between resistance in oxidative stress and colour morphs in natural conditions. Nestling GSH levels were correlated with GSH levels in their genetic and foster parents suggesting that producing GSH is genetically and environmentally determined (although the effect of the foster nest seemed stronger). This species shows continuous variation in phe - omelanin reddish colouration, which is associated with life-history strategies. Based on the hypothesis of GSH dependence of pheomelanism, we expected a greater amount of oxGSH in dark compared to light pheomelanic nestlings, which was not the case. In contrast, light melanic breeding adults had higher levels of t GSH and redGSH than dark breeders probably because of a higher investment in antioxidant capacity. The link between pheomelanism and GSH may therefore be due to the fact that differently colored individuals have different life-history strategies rather than because the production of pheomelanin pigments requires GSH.</p>
Importance of melanin-based colouration and environment in shaping intracellular glutathione levels in nestling and adult tawny owls (Strix aluco)
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The lack of the TetR-like repressor gene BCG_2177c (Rv2160A) may help mycobacteria overcome intracellular redox stress and survive longer inside macrophages when surrounded by a lipid environment
GEO Series GSE175579. Mycobacterium tuberculosis variant bovis BCG. 8 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.