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3 results for “intracranial calcifications”
The Correlation of Intracranial Artery Calcification and Outcomes of Mechanical Thrombectomy
ClinicalTrials.gov study NCT06418698. IPD Sharing: NO. Countries: 1. Publications: 0.
Association between Medial Intracranial Carotid Artery Calcifications and Hematoma Expansion in Deep Intracerebral Hemorrhage.
<p>Background: Medial intracranial carotid arteries calcifications (ICAC) are associated with impaired vascular physiology, increased arterial stiffness and pulse pressure. Their presence might therefore be associated with increased risk of intracerebral hemorrhage (ICH) expansion, according to the avalanche model. We explored the association between ICAC presence and pattern and hematoma expansion (HE).</p> <p>Methods: retrospective analysis of a monocentric, prospectively collected cohort of ICH patients admitted between June 2017 and October 2023. ICAC pattern was determined by Kockelkoren’s rating scale on admission CT and medial ICAC were defined with a > 6 points cutoff. HE was analyzed as a dichotomous (≥6 mL and/or ≥33%) and as a categorical (none/mild/moderate/severe) variable and its predictors were explored with logistic and ordinal regression respectively, accounting for baseline volume, onset-to-CT time and anticoagulation. All the analyses were stratified by ICH location (supratentorial deep vs lobar ICH).</p> <p>Results: A total of 201 patients were included (median age 78, 42% females, 59% deep ICH). Medial ICAC were significantly more common in deep ICH with HE compared to non-expanders (72% vs 49%, p=0.03) whereas there was no association between ICAC and HE in lobar ICH (53% vs 52%, p=0.85).This association between medial ICAC and HE in deep ICH remained significant in logistic (aOR 3.11, 95%CI [1.19-9.06], p=0.03) and ordinal regression (acOR 2.42, 95%CI [1.19-4.99], p=0.01).</p> <p>Interpretation: Ipsilateral medial ICAC are associated with higher odds of HE in deep ICH. Our findings are best interpreted as hypothesis generating, requiring prospective validation and further research to characterize the underlying biological mechanisms.</p>
Intracranial carotid artery calcification morphology differs in patients with lacunar and non-lacunar acute ischemic strokes
<p><strong>Introduction. </strong>This database includes the raw data linked with the paper "Intracranial carotid artery calcification morphology differs in patients with lacunar and non-lacunar acute ischemic strokes".</p> <p>In this paper, we reported the association of diverse pattern of intracranial carotid artery calcifications (ICAC) and etiologic subtypes of ischemic stroke.</p> <p><strong>Methods.</strong> We retrospectively analyzed a single center cohort of patients admitted for ischemic stroke with known etiology. Patients with a first ischemic stroke with lacunar, cardioembolic or atherothrombotic large artery disease etiology were included. Each carotid artery was evaluated separately on NCCT scans to define the ICAC pattern. The association of ICAC patterns and stroke etiology was investigated using two logistic regression models adjusting for confounders.</p> <p><strong>Results.</strong> A total of 300 patients were included in the analysis, mean age 78 years (+-10), 158 (53%) female, median NIHSS 6 (IQR 9). Prevalence of medial, intimal, and mixed calcification was: 73%, 17% and 11% in cardioembolic stroke, 66%, 25% and 9 % in large artery atherosclerosis stroke and 37%, 44% and 19% in lacunar stroke (p<0.001). After adjustment for confounders, intimal pattern (OR=2.14; 95%CI=1.07-4.30), and medial pattern (OR=0.33; 95CI%=0.16-0.67) remained independently associated with lacunar stroke etiology. In conclusion, our study suggests that intimal ICAC pattern is associated with lacunar stroke, and, if validated in further studies, it may serve as a marker for lacunar stroke etiology.</p>
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