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71 results for “invasive aspergillosis”
Scripts to perform dynamic optimization of a model of invasive aspergillosis
<p>Matlab scripts to perform optimization and analyses of a dynamic optimization model of invasive aspergillosis:<br> "Dynamic optimization reveals alveolar epithelial cells as key mediators of host defense in invasive aspergillosis"<br> Jan Ewald, Flora Rivieccio, Lukáš Radosa, Stefan Schuster, Axel A. Brakhage, Christoph Kaleta<br> https://doi.org/10.1101/2021.05.12.443764</p> <p>File structure:</p> <p>--- Core optimization files ---<br> -- simulation.cpp --<br> Description of ODE model in 'C', used by solver to calculate the time course given the parameters, initial states and control variables</p> <p>-- simulation.mexa64 --<br> Compiled mex-File from simulation.cpp used as interface by MATLAB to 'C' files.</p> <p>-- optFun.m --<br> Definition of the objective function. Uses a control vector 'u' to calculate the, objective function value F, the time course of state variables 'x' and gradients used by the solver to determine the optimal control of 'u'.</p> <p>-- single_opt.m --<br> Function which performs an optimization run for a given parameter set and a randomized initial solution u0. Optimization can be conducted by SNOPT or in conjunction with IPOPT. Both solver are not provided here (proprietary).</p> <p><br> --- Additional files ---<br> -- solve_with_ipopt.m --<br> Configuration file and interface to call the solver IPOPT.</p> <p>-- lognorm_mu.m --<br> Function to provide log-normal distributed samples given the standard deviation, reference value (mode of distribution) and number of samples which should be calculated.</p> <p>-- mice_param_alv.m --<br> Reference parameter set of the model for mice as host organism and cell numbers normalized per alveolus.</p> <p>-- parameter_model.m --<br> Definition of parameter container to handle interface to optFun-call by solvers which do not allow parameter in function call.</p> <p>--- Optimization Runs ---<br> -- rand_params.m --<br> Performs optimization runs for multiple randomized parameter sets and several scenarios to determine parameter sensitivity.</p> <p>-- doseresponse.m --<br> Performs optimization runs for a sequnce of initial conidial dosages to determine the dose response of the system.</p> <p>--- Scripts for post-analysis ---<br> -- rand_analysis.m --<br> Loads the data created by the optimization runs (rand_params.m) and performs parameter sensitivity analysis as well as produces plots for analysis related to parameter influence.</p> <p>-- doseanalysis.m --<br> Loads the data created by the optimization runs (doseresponse.m ) and produces dose response curves as well as additional plots and analyses.</p> <p>--- Optimization output files ---<br> -- rand_param_out/ --<br> Folder contains optimization results as MATLAB session-file for randomized parameters used for parameter sensitivity analysis.</p> <p>-- dose_out/ --<br> Folder contains optimization results as MATLAB session-file for dose response curve calculation.</p>
Caspofungin Maximum Tolerated Dose in Patients With Invasive Aspergillosis
ClinicalTrials.gov study NCT00404092. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Anidulafungin Plus Voriconazole Versus Voriconazole For The Treatment Of Invasive Aspergillosis
ClinicalTrials.gov study NCT00531479. IPD Sharing: Not stated. Countries: 24. Publications: 3.
Nebulized Amphotericin B Lipid Complex in Invasive Pulmonary Aspergillosis in Paediatric Patients With Acute Leukaemia
ClinicalTrials.gov study NCT01615809. IPD Sharing: YES. Countries: 1. Publications: 15.
A Study To Evaluate The Safety Of Voriconazole As Treatment Of Invasive Aspergillosis (Fungal Infection) And Other Rare Molds In Children
ClinicalTrials.gov study NCT00836875. IPD Sharing: Not stated. Countries: 8. Publications: 1.
A Study to Evaluate Isavuconazonium Sulfate for the Treatment of Invasive Aspergillosis (IA) or Invasive Mucormycosis (IM) in Pediatric Participants
ClinicalTrials.gov study NCT03816176. IPD Sharing: NO. Countries: 3. Publications: 1.
Isavuconazole (BAL8557) for Primary Treatment of Invasive Aspergillosis
ClinicalTrials.gov study NCT00412893. IPD Sharing: YES. Countries: 26. Publications: 3.
Posaconazole (MK-5592) Intravenous and Oral in Children With Invasive Aspergillosis (IA) (MK-5592-104)
ClinicalTrials.gov study NCT04218851. IPD Sharing: YES. Countries: 10. Publications: 1.
Prospective Multicenter Evaluation of the MycoGenie Kit for the Diagnosis of Invasive Aspergillosis
ClinicalTrials.gov study NCT03349931. IPD Sharing: NO. Countries: 1. Publications: 2.
Voriconazole vs. Amphotericin B in the Treatment of Invasive Aspergillosis
ClinicalTrials.gov study NCT00001646. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Novel Biomarkers for Invasive Aspergillosis
ClinicalTrials.gov study NCT03004092. IPD Sharing: Not stated. Countries: 1. Publications: 6.
Prevalence of Influenza RelAted Invasive Aspergillosis
ClinicalTrials.gov study NCT04172610. IPD Sharing: YES. Countries: 1. Publications: 1.
Azole-echinocandin Combination Therapy for Invasive Aspergillosis
ClinicalTrials.gov study NCT04876716. IPD Sharing: Not stated. Countries: 2. Publications: 1.
Inhalation of Liposomal Amphotericin B to Prevent Invasive Aspergillosis
ClinicalTrials.gov study NCT00263315. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Diagnosing Invasive Aspergillosis by Polymerase Chain Reaction (PCR) Based Investigation of Bronchoalveolar Lavage Samples During Antifungal Therapy
ClinicalTrials.gov study NCT01448226. IPD Sharing: Not stated. Countries: 2. Publications: 4.
Diagnostic and Management Strategies for Invasive Aspergillosis
ClinicalTrials.gov study NCT00816088. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Diagnosis of Invasive Pulmonary Aspergillosis (IPA) in Critically Ill Patients
ClinicalTrials.gov study NCT01866020. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study of FK463 for the Treatment of Invasive Aspergillosis
ClinicalTrials.gov study NCT00036166. IPD Sharing: Not stated. Countries: 8. Publications: 2.
Early Diagnosis of Invasive Lung Aspergillosis
ClinicalTrials.gov study NCT05860387. IPD Sharing: NO. Countries: 1. Publications: 38.
A Study of the Safety and Efficacy of Posaconazole Versus Voriconazole for the Treatment of Invasive Aspergillosis (MK-5592-069)
ClinicalTrials.gov study NCT01782131. IPD Sharing: YES. Countries: 0. Publications: 2.
ScienceDex guides
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