Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
57
datasets available to search
ShareScore release 0.9.0
Dataset results
57 results for “isoflurane”
Functional MRI data from medetomidine-isoflurane anesthetized marmosets
<p>This dataset contains unprocessed <strong>functional MRI (fMRI)</strong> data acquired in <strong>common marmosets</strong> (<em>Callithrix jacchus</em>), The data were obtained during a continuous infusion of the sedative <strong>medetomidine</strong>, supplemented with a low concentration of <strong>isoflurane</strong>. All experiments were carried out in accordance with the guidelines from Directive 2010/63/EU of the European Parliament on the protection of animals used for scientific purposes.</p> <p><strong>Related paper</strong></p> <p>This dataset supplements the following <a href="https://www.biorxiv.org/content/10.1101/2023.11.21.568138v1.abstract">manuscript</a>.</p> <p><strong>Preserving functional network structure under anesthesia in the marmoset monkey brain</strong></p> <p>M Ortiz-Rios, N Sirmpilatze, J Koenig, S Boretius - bioRxiv, 2023</p> <p><strong>doi: <a href="https://doi.org/10.1101/2023.11.21.568138">https://doi.org/10.1101/2023.11.21.568138</a> </strong></p> <p><strong>Data structure</strong></p> <p>The main data files are organized into eight zipped folders - <em><strong>sub-02.tar.gz, .... sub-09.tar.gz </strong></em> - each constituting a dataset formatted according to the <a href="https://bids.neuroimaging.io/">Brain Imaging Data Structure</a> specifications (BIDS v1.6.0).</p> <ul> <li>Each BIDS-formatted dataset contains subfolders for individual sessions (e.g. <em><strong>ses-0001</strong>, </em>etc.).Additionally, a text file, <strong><em>participants.tsv</em></strong>, with some essential information about the subjects (e.g. age, weight, sex).</li> <li>Each subject-specific folder contains subfolders named <em><strong>func</strong> </em>and <strong><em>anat</em></strong>, storing fMRI and structural MRI data respectively. The (f)MRI data are provided in <a href="https://nifti.nimh.nih.gov/">NIfTI format</a> (suffixed with <strong><em>.nii.gz</em></strong>). </li> <li>The <em><strong>func</strong></em> files are named as <strong><em>{sub-id}_{ses-id}_{run-id}_{task-id}_bold.nii.gz. </em></strong>The task id is based on runs acquired for resting-state or during visual stimulation.</li> </ul> <p><strong>BIDS-formatted dataset</strong></p> <p>The basic characteristics of the datasets are given below. More details can be found in the <a href="https://www.biorxiv.org/content/10.1101/2023.11.21.568138v1.abstract">preprint</a>.</p> <ol> <li><em><strong>Marmoset</strong></em> <ul> <li><strong>Institution:<em> </em></strong>German Primate Center (Deutsches Primatenzentrum GmbH - Leibniz-Institut für Primatenforschung), Göttingen, Germany</li> <li><strong>MR system:</strong> Bruker BioSpec 9.4 T, equpped with B-GA 20S gradient</li> <li><strong>Anatomical MRI scan:</strong> Proton density-weighted (PDw) with magnetization transfer (MT) pulse, 1 per subject</li> <li><strong>fMRI scan:</strong> GE-EPI, several runs per subject (between 6 and 9 runs), duration 330 s for visual runs and 600 s for resting-state runs, all with a TR of 2 s and a resolution of 0.4 mm isotropic.</li> <li><strong>Subjects:</strong> 8 <em>Callithrix jacchus</em></li> <li><strong>Age range:</strong> 2.6 - 9.5 years</li> <li><strong>Weight range:</strong> 375 - 517 g</li> <li><strong>Sex:</strong> 5 males and 3 females</li> <li><strong>Ethics oversight:</strong> Lower Saxony State Office for Consumer Protection and Food Safety, Hannover, Germany (approval numbers 33.19-42502-04-17/2496)</li> </ul> </li> </ol>
Functional MRI data from isoflurane-anesthetized macaques, marmosets, and rats
<p>This dataset contains unprocessed task-free <strong>functional MRI (fMRI)</strong> data acquired in three different mammalian species: <strong>long-tailed macaques</strong> (<em>Macaca fascicularis</em>), <strong>common marmosets</strong> (<em>Callithrix jacchus</em>), and <strong>rats</strong> (<em>Rattus Norvegicus</em>, Wistar strain). The data were obtained during <strong>isoflurane anesthesia</strong>, with the animals intubated and mechanically ventilated. All experiments were carried out in accordance with the guidelines from Directive 2010/63/EU of the European Parliament on the protection of animals used for scientific purposes.</p> <p><strong>Related paper</strong></p> <p>This dataset supplements the following <a href="http://doi.org/10.7554/eLife.74813">manuscript</a>:</p> <p>Sirmpilatze N, Mylius J, Ortiz-Rios M, Baudewig J, Paasonen J, Golkowski D, Ranft A, Ilg R, Gröhn O, Boretius S. <em>Spatial signatures of anesthesia-induced burst-suppression differ between primates and rodents.</em> eLife 2022;11:e74813. DOI: https://doi.org/10.7554/eLife.74813</p> <p><strong>Data structure</strong></p> <p>The main data files are organized into four zipped folders - <em><strong>Macaque.zip, Marmoset.zip, Rat1.zip, Rat2.zip</strong></em> - each constituting a dataset formatted according to the <a href="https://bids.neuroimaging.io/">Brain Imaging Data Structure</a> specifications (BIDS v1.6.0).</p> <ul> <li>Each BIDS-formatted dataset contains subfolders for individual subjects (e.g. <em><strong>sub-01</strong>, <strong>sub-02</strong>,</em> etc.), as well as a tab-separated text file, <strong><em>participants.tsv</em></strong>, with some essential information about the subjects (e.g. age, weight, sex).</li> <li>Each subject-specific folder contains subfolders named <em><strong>func</strong> </em>and <strong><em>anat</em></strong>, storing fMRI and structural MRI data respectively. The (f)MRI data are provided in <a href="https://nifti.nimh.nih.gov/">NIfTI format</a> (suffixed with <strong><em>.nii.gz</em></strong>). Each NIfTI file is accompanied by a <strong><em>.json sidecar</em></strong> holding metadata.</li> <li>The <em><strong>func</strong></em> subfolders also include tab-separated text files named as <strong><em>{sub-id}_scans.tsv</em></strong> (e.g. <em><strong>sub-01_scans.tsv</strong></em>). These files provide additional information on the fMRI runs within the <em><strong>func</strong></em> subfolder, such as the isoflurane concentration during the acquisition of the fMRI run, duration of the run, etc.</li> <li>The column names in <em><strong>participants.tsv</strong></em> and <em><strong>{sub-id}_scans.tsv</strong></em> files are explained in accompanying <em><strong>participants.json </strong></em>and <em><strong>{sub-id}_scans.json</strong></em> files.</li> </ul> <p><strong>BIDS-formatted datasets</strong></p> <p>The basic characteristics of the datasets are given below. More details can be found in the <a href="https://www.biorxiv.org/content/10.1101/2021.10.15.464515">preprint</a>.</p> <ol> <li><em><strong>Macaque</strong></em> <ul> <li><strong>Institution:<em> </em></strong>German Primate Center (Deutsches Primatenzentrum GmbH - Leibniz-Institut für Primatenforschung), Göttingen, Germany</li> <li><strong>MR system:</strong> Siemens MAGNETOM Prisma 3T</li> <li><strong>Anatomical MRI scan:</strong> T1-weighted (MPRAGE), 1 per subject</li> <li><strong>fMRI scan:</strong> GE-EPI, 1 or 2 runs per subject, run duration 600 - 1200 s</li> <li><strong>Subjects:</strong> 13 <em>Macaca fascicularis</em></li> <li><strong>Age range:</strong> 6.8 - 19.8 years</li> <li><strong>Weight range:</strong> 3.6 - 8.1 kg</li> <li><strong>Sex:</strong> all females</li> <li><strong>Ethics oversight:</strong> Lower Saxony State Office for Consumer Protection and Food Safety, Hannover, Germany (approval number 33.19-42502-04-16/2278)</li> </ul> </li> <li><em><strong>Marmoset</strong></em> <ul> <li><strong>Institution:<em> </em></strong>German Primate Center (Deutsches Primatenzentrum GmbH - Leibniz-Institut für Primatenforschung), Göttingen, Germany</li> <li><strong>MR system:</strong> Bruker BioSpec 9.4 T, equpped with B-GA 20S gradient</li> <li><strong>Anatomical MRI scan:</strong> Proton density-weighted (PDw) with magnetization transfer (MT) pulse, 1 per subject</li> <li><strong>fMRI scan:</strong> GE-EPI, 1 run per subject, run duration 600 s (except for sub-21, containing 4 runs of 300 s duration each).</li> <li><strong>Subjects:</strong> 21 <em>Callithrix jacchus</em></li> <li><strong>Age range:</strong> 1.9 - 14.2 years</li> <li><strong>Weight range:</strong> 337 - 517 g</li> <li><strong>Sex:</strong> 11 females</li> <li><strong>Ethics oversight:</strong> Lower Saxony State Office for Consumer Protection and Food Safety, Hannover, Germany (approval numbers 33.19-42502-04-17/2496 and 33.19-42502-04-17/2535)</li> </ul> </li> <li><em><strong>Rat1</strong></em> <ul> <li><strong>Institution:<em> </em></strong>German Primate Center (Deutsches Primatenzentrum GmbH - Leibniz-Institut für Primatenforschung), Göttingen, Germany</li> <li><strong>MR system:</strong> Bruker BioSpec 9.4 T, equpped with B-GA 12S2 gradient</li> <li><strong>Anatomical MRI scan:</strong> T2-weighted (TurboRARE), 1 per subject</li> <li><strong>fMRI scan:</strong> GE-EPI, 6 runs per subject (except for sub-10: 4 runs), run duration 720 s</li> <li><strong>Subjects:</strong> 11 <em>Rattus norvegicus</em>, Wistar strain</li> <li><strong>Weight range:</strong> 350 - 450 g</li> <li><strong>Sex:</strong> all females</li> <li><strong>Ethics oversight:</strong> Lower Saxony State Office for Consumer Protection and Food Safety, Hannover, Germany (approval number 33.19-42502-04-15/2042)</li> </ul> </li> <li><em><strong>Rat2</strong></em> <ul> <li><strong>Institution:<em> </em></strong>A.I.V. Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland</li> <li><strong>MR system:</strong> Bruker PharmaScan 7 T</li> <li><strong>Anatomical MRI scan:</strong> NOT provided</li> <li><strong>fMRI scan:</strong> GE-EPI, 6 runs per subject (except for sub-10: 4 runs), run duration 720 s</li> <li><strong>Subjects:</strong> 6 <em>Rattus norvegicus</em>, Wistar strain</li> <li><strong>Weight range:</strong> 265 - 350 g</li> <li><strong>Sex:</strong> all males</li> <li><strong>Ethics oversight:</strong> Animal Ethics Committee of the Provincial Government of Southern Finland</li> </ul> </li> </ol> <p><strong>Example data</strong></p> <p>Before you commit to downloading the BIDS-formatted datasets, we encourage you to examine the example data that we provide in the root folder. These include one anatomical (stuctural MRI) and one functional (fMRI) scan from each of the four datasets (Rat2 contains functional scans only), with their respecitve <strong><em>.json sidecars</em></strong>. A preview of these example scans is provided by <em><strong>0_preview.pdf.</strong></em></p>
Closed Loop Isoflurane Administration With Bispectral Index in Open Heart Surgery
ClinicalTrials.gov study NCT01069562. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU2)
ClinicalTrials.gov study NCT05327296. IPD Sharing: Not stated. Countries: 1. Publications: 16.
Efficacy and Safety of Inhaled Isoflurane Delivered Via the Sedaconda ACD-S Compared to Intravenous Propofol for Sedation of Mechanically Ventilated Intensive Care Unit Adult Patients (INSPiRE-ICU1)
ClinicalTrials.gov study NCT05312385. IPD Sharing: NO. Countries: 1. Publications: 16.
Effect & Safety of Inhaled Isoflurane vs IV Midazolam for Sedation in Mechanically Ventilated Children 3-17 Years Old
ClinicalTrials.gov study NCT04684238. IPD Sharing: NO. Countries: 5. Publications: 16.
Trazodone and dexmedetomidine cause fentanyl to decrease the isoflurane minimum alveolar concentration in cats
Open the record for dataset details and reuse information.
Data from: Isoflurane anesthesia alters <sup>31</sup>P magnetic resonance spectroscopy markers compared to awake mouse brain
Open the record for dataset details and reuse information.
Dobutamine improves hemodynamics and oxygen delivery in standing and isoflurane-anesthetized horses
Open the record for dataset details and reuse information.
Data from: Rat aversion to isoflurane versus carbon dioxide
Some experts suggest that sedation of laboratory rodents with isoflurane before euthanasia with carbon dioxide (CO2) is a humane alternative to euthanasia with CO2 alone, but little research has compared aversion to these agents. Albino rats were tested in a light/dark box where they had the choice between remaining in a dark compartment filling with isoflurane or CO2, or escaping to a lit compartment. Experiment 1 validated the procedure by confirming that rats responded to agent and light intensity. In Experiment 2, 9/16 and 0/16 rats remained in the dark compartment until recumbent when initially exposed to isoflurane and CO2, respectively. In Experiment 3, more rats remained in the dark compartment until recumbent during initial (10/16) versus re-exposure (1/16) to isoflurane. These results indicate that initial exposure to CO2 is more aversive than isoflurane, and that re-exposure to isoflurane is more aversive than initial exposure. We conclude that sedation with isoflurane is a refinement over euthanasia with CO2 alone for rats that have not been previously exposed to inhalant anaesthetics.
Evaluation of the Safety of Inhaled Sedation With Isoflurane in Head Trauma Patients
ClinicalTrials.gov study NCT06311604. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Multicenter Retrospective Study of Isoflurane in Refractory and Super-Refractory Status Epilepticus
ClinicalTrials.gov study NCT05830864. IPD Sharing: UNDECIDED. Countries: 1. Publications: 2.
Inflammatory Cytokines Profile in Individuals Subjected to Surgical Procedures Using Propofol or Isoflurane
ClinicalTrials.gov study NCT01111227. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Randomized Isoflurane and Sevoflurane Comparison in Cardiac Surgery
ClinicalTrials.gov study NCT01477151. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A Pooled Analysis of Long-Term Outcomes After Inhaled Isoflurane Via the Sedaconda ACD-S Compared to Intravenous Propofol
ClinicalTrials.gov study NCT06809218. IPD Sharing: NO. Countries: 1. Publications: 15.
Ketamine Effect on Isoflurane Anesthesia
ClinicalTrials.gov study NCT03290495. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Markers of Alzheimers Disease After Propofol or Isoflurane Anesthesia
ClinicalTrials.gov study NCT01640275. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Sevoflurane vs. Isoflurane for Low-Flow General Anaesthesia for Abdominal Surgery
ClinicalTrials.gov study NCT00521612. IPD Sharing: Not stated. Countries: 1. Publications: 5.
Effect of Atracurium and Rocuronium on the State and Response Entropy During Isoflurane Anesthesia
ClinicalTrials.gov study NCT05097508. IPD Sharing: YES. Countries: 1. Publications: 1.
Inhaled Isoflurane for Sedation of Invasively Ventilated Patients With Cardiogenic Shock on Extracorporeal Membrane Oxygenation
ClinicalTrials.gov study NCT07099014. IPD Sharing: YES. Countries: 0. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.