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8 results for “isradipine”
Inhibition of striatal dopamine release by the L-type calcium channel inhibitor isradipine co-varies with risk factors for Parkinson's
<h3><strong>ABSTRACT</strong></h3> <p>Ca<sup>2+</sup> entry into nigrostriatal dopamine (DA) neurons and axons via L-type voltage-gated Ca<sup>2+</sup> channels (LTCCs) contributes respectively to pacemaker activity and DA release, and has long been thought to contribute to vulnerability to degeneration in Parkinson’s disease. LTCC function is greater in DA axons and neurons from substantia nigra pars compacta than from ventral tegmental area, but this is not explained by channel expression level. We tested the hypothesis that LTCC-control of DA release is governed rather by local mechanisms, focussing on candidate biological factors known to operate differently between types of DA neurons and/or be associated with their differing vulnerability to parkinsonism, including biological sex, α-synuclein, DA transporters (DATs), and calbindin-D28k (Calb1). We detected evoked DA release <em>ex vivo </em>in mouse striatal slices using fast-scan cyclic voltammetry, and assessed LTCC support of DA release by detecting the inhibition of DA release by the LTCC inhibitors isradipine or CP8. Using genetic knockouts or pharmacological manipulations we identified that striatal LTCC support of DA release depended on multiple intersecting factors, in a regionally and sexually divergent manner. LTCC function was promoted by factors associated with Parkinsonian risk, including male sex, α-synuclein, DAT, and a dorsolateral co-ordinate, but limited by factors associated with protection i.e. female sex, glucocerebrosidase activity, Calb1, and ventromedial co-ordinate. Together, these data show that LTCC function in DA axons, and isradipine effect, are locally governed and suggest they vary in a manner that in turn might impact on, or reflect, the cellular stress that leads to parkinsonian degeneration.</p> <p> </p> <h3><strong>FILE DESCRIPTIONS</strong></h3> <p>This repository contains the following files:</p> <ul> <li>Key Resources Table (.xlsx) - Table containing details on key lab materials (antibodies, mouse lines, and software), and the persistent identifiers for protocols and code used and generated in this study. </li> <li>Source Data (.xlsx) - Excel spreadsheet containing all tabular datasets plotted in Main Figures 1 to 5 (.xlsx).</li> <li>R_Scritps (.R) - Custom written R scripts to perform a classification tree analysis.</li> </ul>
Isradipine Enhancement of Virtual Reality Cue Exposure for Smoking Cessation
ClinicalTrials.gov study NCT03083353. IPD Sharing: YES. Countries: 1. Publications: 1.
Improving Buprenorphine Detoxification Outcomes With Isradipine
ClinicalTrials.gov study NCT01895270. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Efficacy of Isradipine in Early Parkinson Disease
ClinicalTrials.gov study NCT02168842. IPD Sharing: UNDECIDED. Countries: 2. Publications: 4.
Dataset to: Isradipine therapy in Cacna1dIle772Met/+ mice with PASNA syndrome (primary aldosteronism, seizures and neurologic abnormalities)
<p>Dataset to:<strong><em> </em></strong><strong><em>Isradipine therapy in Cacna1d<sup>Ile772Met/+</sup> mice with PASNA syndrome (primary aldosteronism, seizures and neurologic abnormalities)</em></strong><strong><em> </em></strong></p>
Evaluating Isradipine for Cognitive Enhancement in Schizophrenia and Schizoaffective Disorder
ClinicalTrials.gov study NCT01658150. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Adjunctive Isradipine for the Treatment of Bipolar Depression
ClinicalTrials.gov study NCT01784666. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Parkinson's Disease Isradipine Safety Study
ClinicalTrials.gov study NCT00753636. IPD Sharing: Not stated. Countries: 1. Publications: 0.
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