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67 results for “keap1”
Human Kelch-like ECH Associated Protein 1 (KEAP1); A Target Enabling Package
<p>KEAP1 is a highly redox-sensitive member of the BTB-Kelch family that assembles with the CUL3 protein to form a Cullin-RING E3 ligase complex for the degradation of NRF2. Oxidative stress disables KEAP1 allowing NRF2 protein levels to accumulate for the transactivation of critical stress response genes. Consequently, the KEAP1-NRF2 system is a highly attractive target for the development of protein-protein interaction inhibitors that will stabilise NRF2 for therapeutic effect in conditions of neurodegeneration and inflammation. As part of this TEP we have solved the first crystal structure of a KEAP1-CUL3 complex as well as a structure of the apo-Kelch domain suitable for small molecule soaking. We further established a selectivity assay panel of 17 human Kelch domain-containing proteins and have shown that non-covalent KEAP1 inhibitors from the literature are highly selective for KEAP1. This protein panel offers a resource for future work on KEAP1 as well as 16 other human Kelch proteins.</p>
RNA-seq based analysis of gene expression in thyroids of wild-type and Keap1 knockdown mice after exposure to excess iodide.
<p>C57BL/6J Keap1flox/flox mice were developed by Prof. Masayuki Yamamoto (DOI: 10.1016/j.bbrc.2005.10.185). These mice express lower levels of Keap1 because of the loxP site insertions (DOI: 10.1128/MCB.01591-09) and are designated as Keap1KD. 3-4 months old WT and Keap1KD mice fed a standard diet (KLIBA NAFAG 3242, Switzerland) containing 1.5 mg/kg sodium iodine were given normal tap water with or without 0.05% sodium iodide (Sigma, St Louis, MO, USA) for 7 days. Hence, the following groups of mice were included:</p> <p>WT mice on control water (n=8)-designated as wt in the file</p> <p>WT mice exposed to excess iodide (WT-IOD, n=6)- designated as wti in the file</p> <p>Keap1KD mice on control water (n=8)- designated as kp in the file</p> <p> and Keap1KD mice exposed to excess iodide (Keap1KD-IOD, n=6)- designated as kpI in the file. </p> <p> Mice were maintained in the animal facility of the Department of Physiology at the University of Lausanne in temperature-, light-, and humidity-controlled rooms with a 12-hour light/dark cycle. All animal procedures were in accordance with Swiss legislature and the study was approved by the Canton of Vaud SCAV.</p> <p>RNA from individual mouse thyroids was prepared as previously described (DOI: 10.1007/978-1-4939-3756-1_25) and was submitted to Alithea Genomics (Switzerland). The bulk RNA barcoding and sequencing (BRB-seq) libraries were generated and sequenced as described previously (DOI: 10.1186/s13059-019-1671-x) to a depth of approximately 1.2 million raw reads per sample.</p> <p>This research was funded by the Swiss National Science Foundation Research Grants 310030_212558, IZCOZ0_205415 and IZCOZ0_177070</p> <p></p> <p></p>
The Keap1-Nrf2-Bach1 signaling mediates UBR7 negative regulation of HK2 to inhibit glycolysis and HCC tumorigenesis
GEO Series GSE173454. Mus musculus. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Selective disruption of NRF2-KEAP1 interaction leads to NASH resolution and reduction of liver fibrosis in mice
GEO Series GSE212644. Mus musculus. 20 samples. Type: Expression profiling by high throughput sequencing.
Single-cell RNA-seq of the esophagus of Keratin5CreERT2::Keap1 floxB/floxB and Keap1 floxB/floxB mice
GEO Series GSE197558. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Effect of a point mutation at Keap1 C151 on hepatic gene expression in mice treated with Bardoxolone Methyl (CDDO-Me)
GEO Series GSE222256. Mus musculus. 30 samples. Type: Expression profiling by high throughput sequencing.
High PRMT5 levels, maintained by KEAP1 inhibition, drive chemoresistance in ovarian cancer [RNA-seq]
GEO Series GSE282674. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Comparison of gene expression profiles of Atg7 or Keap1 knockout mouse livers
GEO Series GSE241215. Mus musculus. 8 samples. Type: Expression profiling by array.
Comparison of gene expression profiles among Nrf1 liver-specific conditional knockout, Nrf2 knockout and Keap1 knockdown mice.
GEO Series GSE35124. Mus musculus. 18 samples. Type: Expression profiling by array.
The KEAP1-NRF2 pathway regulates TFEB/TFE3-dependent lysosomal biogenesis [RNA-seq: HepG2 cells sitfebtfe3]
GEO Series GSE230609. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Sedanolide ameliorates hydrogen peroxide-induced apoptotic cell death via activation of KEAP1-NRF2 pathway
GEO Series GSE245428. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Effect of depletion of KEAP1 on gene expression after LPS and IFN-γ stimulation of THP-1 derived macrophages
GEO Series GSE216352. Homo sapiens. 10 samples. Type: Expression profiling by high throughput sequencing.
The KEAP1-NRF2 pathway regulates TFEB/TFE3-dependent lysosomal biogenesis [RNA-seq: HepG2 cells KeapKO]
GEO Series GSE230608. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Single-cell transcriptomics identifies Keap1-Nrf2 regulated collective invasion in a Drosophila tumor model
GEO Series GSE175435. Drosophila melanogaster. 10 samples. Type: Expression profiling by high throughput sequencing.
Transcriptomic response to Keap1-specific electrophile modification in zebrafish embryos
GEO Series GSE135190. Danio rerio. 3 samples. Type: Expression profiling by high throughput sequencing.
High PRMT5 levels, maintained by KEAP1 inhibition, drive chemoresistance in ovarian cancer [CRISPR screen]
GEO Series GSE282677. Homo sapiens. 8 samples. Type: Other.
Synthetic oleanane triterpenoids reduce tumor growth and promote an anti-tumor immune response independent of cancer KEAP1-mutational status
GEO Series GSE308273. Mus musculus. 24 samples. Type: Expression profiling by high throughput sequencing.
KEAP1-mutant lung cancers weaken anti-tumor immunity and promote an M2-like macrophage phenotype.
GEO Series GSE250166. Mus musculus. 15 samples. Type: Expression profiling by high throughput sequencing.
The Keap1-Nrf2-Bach1 signaling mediates UBR7 negative regulation of HK2 to inhibit glycolysis and HCC tumorigenesis [RNA-seq]
GEO Series GSE173501. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Whole esophagi of WT, Nrf2-/- and Keap1-/- mice on C57BL background at E11.5, E15.5, P0 and P7, and esophageal epithelium of adult (8 weeks old) mice
GEO Series GSE34278. Mus musculus. 27 samples. Type: Expression profiling by array.
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OpenNeuro
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