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21 results for “ki67”
Histopathology pairs of hematoxylin-eosin and Ki67 stainings of testicular seminoma
<p><strong>About</strong></p> <p>Dataset contains <strong>77</strong> pairs of stained sections of testicular seminoma. Each pair is produced from the neighbouring sections of the tissue to guarantee the most similarity possible of the stained tissue. HE and Ki67 images are registered and aligned.</p> <p>When used, please cite the following work: Petríková, D.; Cimrák, I.; Tobiášová, K. and Plank, L. (2024), Dataset of Hematoxylin-eosin and Ki67 histopathological image pairs complemented by algorithms providing Ki67 index, DATA, submitted.</p> <p><strong>Data composition:</strong></p> <p>Dataset is comprised of 154 PNG files. 77 files with prefix id_HE contain images of HE staining, and 77 files with prefix id_Ki67 contain images of Ki67 staining. Both files in each pair id_HE_string.png and id_Ki67_string.png have the same resolution with avarage value 35000px x 35000px. Data is available in 39 ZIP files each containig two HE. images and two of their Ki67 counterparts. For example, 03.zip contains the following files:</p> <ul> <li>05_HE_slide-011-A1-S1-B11.png,</li> <li>05_Ki67_slide-012-A1-S2-B12.png,</li> <li>06_HE_slide-013-A1-S1-B13.png,</li> <li>06_Ki67_slide-014-A1-S2-B14.png.</li> </ul> <p>Image names contain an additional random string. An example of a HE - Ki67 pair is in file HE-Ki67_pair.png.</p> <p><strong>Data preprocessing:</strong></p> <p>Original scans of tissues contained pairs of HE and Ki67 staining with rotated and shifted tissues. Therefore a preprocessing of image registration was performed to find an affine transformation for rotation and translation. The concrete steps of image registration was described in [Petrikova 2024]. Provided images are already aligned.</p> <p><strong>Data usage:</strong></p> <p>This dataset is aimed for AI models to predict the Ki67 index or even to generate Ki67 staining. Since one pair of HE and Ki67 images contain two physically different sections of tissue (although the neighbouring), there is no one-to-one correspondence on cellural level. However patches, created on the same locations from the images in one pair, containe similar quantitative characteristics, such as number of cells, number of Ki67 positive cells, averaged cell size, etc. In [Petrikova2024B] we elaborate the usage of the dataset by computing Ki67 index of HE patches evaluated from corresponding Ki67 patch. </p> <p><strong>References:</strong></p> <p>[Petrikova2024] Petríková, D.; Cimrák, I.; Tobiášová, K. and Plank, L. (2024). Ki67 Expression Classification from HE Images with Semi-Automated Computer-Generated Annotations. In <em>Proceedings of the 17th International Joint Conference on Biomedical Engineering Systems and Technologies - BIOINFORMATICS</em>; ISBN 978-989-758-688-0; ISSN 2184-4305, SciTePress, pages 536-544. DOI: 10.5220/0012535900003657</p> <p>[Petrikova2024B] Petríková, D.; Cimrák, I.; Tobiášová, K. and Plank, L. (2024), Dataset of Hematoxylin-eosin and Ki67 histopathological image pairs complemented by algorithms providing Ki67 index, DATA, submitted.</p>
Usefulness of Ki67 Index in Hormone Receptor-positive Breast Cancer
ClinicalTrials.gov study NCT01273415. IPD Sharing: Not stated. Countries: 1. Publications: 1.
"Neo-Adjuvant Treatment With Palbociclib: Effect on Ki67 and Apoptosis Before, During and After Treatment "
ClinicalTrials.gov study NCT02530424. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Data from: Prognostic value of ki67 in BCG-treated non-muscle invasive bladder cancer: a meta-analysis and systematic review
Objectives: The aim of this study was to explore the prognostic value of ki67 as a marker in non-muscle-invasive bladder cancer (NMIBC) patients treated with Bacillus Calmette–Guérin (BCG). Methods: Studies were systematically retrieved from the relevant databases (Web of Science, PubMed, Cochrane Library, and Embase), and the expiry date was May 2017. The research steps referred to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis statement. Results: A total of 11 studies that complied with the inclusion criteria were enrolled. The expression of ki67 was not statistically significantly associated with recurrence-free survival (RFS) [hazard ratio (HR): 1.331; 95% CI: 0.980–1.809)]. No significant heterogeneity was found among all included studies (I2 = 36.7%, P = 0.148). The expression of ki67 was statistically significantly associated with progression-free survival (PFS) (HR: 2.567; 95% CI: 1.562–4.219), and the overexpression of ki67 was the risk factor for PFS. Significant heterogeneity was noted among all the included studies (I2 = 55.6%, P = 0.021). The studies that might cause heterogeneity were excluded using the Galbraith plot, and then the meta-analysis was performed again. The results showed that the expression of ki67 was still associated with PFS (HR: 2.922; 95% CI: 2.002–4.266). Conclusions: The overexpression of ki67 was the risk factor for PFS, and the relationship between the expression of ki67 and RFS was not statistically significant in patients with NMIBC treated with BCG intravesical immunotherapy. Well-designed, prospective, randomized controlled trials with a large sample size are still needed to validate the findings.
A Study of Changes in Ki67 Expression in People With Breast Cancer Receiving Endocrine Therapy Before Surgery
ClinicalTrials.gov study NCT06127979. IPD Sharing: YES. Countries: 1. Publications: 0.
Preoperative Window Opportunity Study With Giredestrant or Tamoxifen in Premenopausal Women With ER+/HER2[-] & Ki67≥10%
ClinicalTrials.gov study NCT05659563. IPD Sharing: NO. Countries: 2. Publications: 0.
Data from: Prognostic value of ki67 in BCG-treated non-muscle invasive bladder cancer: a meta-analysis and systematic review
Open the record for dataset details and reuse information.
Regeneration signatures of TGFB1-treated mouse intestinal organoids and Ki67 positive primary cells sorted from mice after irradiation
GEO Series GSE222505. Mus musculus. 43 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
Dynamic genome-wide interaction patterns elucidate the roles of Ki67 in chromatin organization
GEO Series GSE186206. Homo sapiens. 213 samples. Type: Other; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing.
DS4_KI67_RawData
<p>Raw data for KI67 enrichment analysis (Fig.3) in 'Oxaliplatin disrupts nucleolar function through biophysical disintegration' (Schmidt et al., 2022, Cell Reports).</p>
Impact of Endocrine Therapy, Menstrual Cycle, PAM50, Ki67 on Treatment Decisions in HR+ and HER2- Breast Cancer
ClinicalTrials.gov study NCT05878314. IPD Sharing: NO. Countries: 1. Publications: 0.
Regulation of Vitamin D Receptor (VDR),Calcium Sensing Receptor (CaSR), Cyclin D1,Ki67 and Proliferating Cell Nuclear Antigen (PCNA) in Primary Hyperparathyroidism
ClinicalTrials.gov study NCT01228786. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Comparison of CNB and Surgical Specimens for ER, PgR, HER2 Status and Ki67 Index in Invasive Breast Cancer.
ClinicalTrials.gov study NCT02773784. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Ki67-mediated chromatin accessibility impedes B-cell antigen-receptor gene rearrangement
GEO Series GSE246986. Mus musculus. 24 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Characterization by gene expression arrays of the human CRC populations according to the Ki67 and Lgr5 expression levels
GEO Series GSE92961. Homo sapiens. 16 samples. Type: Expression profiling by array.
Staining of KI67
Open the record for dataset details and reuse information.
Ki67 Proliferation Index of Pancreatic Neuroendocrine Neoplasia
ClinicalTrials.gov study NCT04753229. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Calcitriol supplementation effects on Ki67 expression and transcriptional profile of breast cancer specimens from post-menopausal patients
GEO Series GSE35925. Homo sapiens. 30 samples. Type: Expression profiling by array.
Gene expression profile at single cell level of aortic cells from 2 adult R26-DreER;Ki67-CrexER;R26-GFP;Kdr rox/rox (Kdr-KO) mice after 8weeks of tamoxifen treatment.
GEO Series GSE234386. Mus musculus. 1 samples. Type: Expression profiling by high throughput sequencing.
SRSF3-mediated Ki67 exon 7 alternative splicing regulates Head and Neck Squamous Cell Carcinoma progression via AKR1C2
GEO Series GSE213022. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
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