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431 results for “kidney functions”
Immune checkpoint molecule TIGIT regulates kidney T cell functions and mediates acute kidney injury
<p>This dataset includes the single cell RNA-seq data associated with the publication listed in the title (abstract below).<br> <br> CellRanger.zip contains the raw transcript counts as produced by CellRanger. There is one folder per sample. The samples are indicated by the folder name (e.g. KO_Ctrl). <br> <br> We have also included .h5ad files that contain of cells that passed quality control, as described in the manuscript.<br> <br> adTIGIT_raw_031422.h5ad contains all passing cells and the raw counts, as well as cell annotations ('celltype')<br> <br> adTIGIT_Tonly_091421.h5ad contains only T cells, .X contains the normalized data and T-cell sub-type ('cluster').<br> <br> Abstract: T cells mediate pathologic and reparative processes during acute kidney injury (AKI) but exact mechanisms regulating kidney T cell functions are unclear. This study identified upregulation of the novel immune checkpoint molecule, TIGIT, on mouse and human kidney T cells following AKI. TIGIT-expressing kidney T cells produced proinflammatory cytokines and had effector and central memory phenotype. Kidney Tregs were predominantly TIGIT+ and reduced after ischemia reperfusion (IR) injury. TIGIT deficient mice had protection from both ischemic and nephrotoxic AKI. Single cell RNA sequencing led to discovery of possible downstream targets of TIGIT. TIGIT mediates AKI pathophysiology, is a promising target for developing AKI therapy, and is being increasingly studied in human cancer therapy trials.</p>
Study Exploring the Effect of Crizanlizumab on Kidney Function in Patients With Chronic Kidney Disease Caused by Sickle Cell Disease
ClinicalTrials.gov study NCT04053764. IPD Sharing: YES. Countries: 11. Publications: 2.
Epigenome-wide association study of kidney function identifies trans-ethnic and ethnic-specific loci
<p>Trans-ethnic meta-analysis results for eGFR EWAS</p> <p>Description of variables:</p> <p>CpG CPG name<br> chr Chromosome <br> pos_hg38 Position hg38 <br> Beta Effect <br> SE Standard error <br> P P value <br> totalsamplesize number of participants <br> direction direction of effect for studies <br> hetpval P value for heterogeneity <br> hetdf Degree of freedom <br> gene Gene location</p> <p>Upload of this dataset was completed by The EWAS Catalog team. The data can be queried along with hundreds of other EWAS at ewascatalog.org. To upload your EWAS summary statistics and have a zenodo DOI generated for you go to ewascatalog.org/upload. </p>
Study of Pharmacokinetics and Safety of Apraglutide in Participants With Normal and Impaired Kidney Function.
ClinicalTrials.gov study NCT04699032. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Can Dapagliflozin Preserve Structure and Function in Transplanted Kidneys?
ClinicalTrials.gov study NCT05788276. IPD Sharing: NO. Countries: 1. Publications: 0.
Perioperative Aminophylline to Improve Early Kidney Function After a Kidney Transplant
ClinicalTrials.gov study NCT01759862. IPD Sharing: Not stated. Countries: 1. Publications: 4.
A Multicenter Clinical Trial of Allopurinol to Prevent Kidney Function Loss in Type 1 Diabetes
ClinicalTrials.gov study NCT02017171. IPD Sharing: Not stated. Countries: 3. Publications: 7.
HIV and Kidney Function Study
ClinicalTrials.gov study NCT00905151. IPD Sharing: NO. Countries: 1. Publications: 2.
A Study of Tirzepatide (LY3298176) in Participants With Impaired Kidney Function
ClinicalTrials.gov study NCT03482024. IPD Sharing: NO. Countries: 1. Publications: 1.
A Study To Evaluate The Effect Of CP-690,550 On Measures Of Kidney Function In Patients With Active Rheumatoid Arthritis
ClinicalTrials.gov study NCT01484561. IPD Sharing: Not stated. Countries: 8. Publications: 9.
Study to Assess the Blood Levels and Safety of Olaparib in Patients With Advanced Solid Tumours and Normal or Impaired Kidney Function
ClinicalTrials.gov study NCT01894256. IPD Sharing: Not stated. Countries: 5. Publications: 1.
Safety of Continuing Metformin in Diabetic Patients With Normal Kidney Function Receiving Contrast Media
ClinicalTrials.gov study NCT01873859. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Pharmacokinetics and Safety of MB-102 (Relmapirazin) and the MediBeacon Transdermal GFR Measurement System in Evaluation of Kidney Function in Normal and Renal Compromised Subjects
ClinicalTrials.gov study NCT05425719. IPD Sharing: NO. Countries: 2. Publications: 1.
Effect of Remote Ischaemic Preconditioning on Renal Function in Patients Undergoing Living Donor Kidney Transplantation
ClinicalTrials.gov study NCT01289548. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Study to Evaluate the Efficacy and Safety of Remdesivir in Participants With Severely Reduced Kidney Function Who Are Hospitalized for Coronavirus Disease 2019 (COVID-19)
ClinicalTrials.gov study NCT04745351. IPD Sharing: YES. Countries: 6. Publications: 2.
Human Brain Natriuretic Peptide (BNP) (or Nesiritide) to Help Heart, Kidney and Humoral Function.
ClinicalTrials.gov study NCT00405548. IPD Sharing: Not stated. Countries: 1. Publications: 1.
"Residual Kidney Function and Oxidative Stress in Incremental vs Standard Peritoneal Dialysis (2 Mexican Centers)"
ClinicalTrials.gov study NCT07338435. IPD Sharing: YES. Countries: 1. Publications: 3.
Safety and Efficacy Study of Sotagliflozin on Glucose Control in Participants With Type 2 Diabetes, Moderate Impairment of Kidney Function, and Inadequate Blood Sugar Control
ClinicalTrials.gov study NCT03242252. IPD Sharing: NO. Countries: 16. Publications: 1.
Safety in Immunomodulatory Functions of Alemtuzumab (Campath) in Pediatric Kidney Transplantation Recipients
ClinicalTrials.gov study NCT00240994. IPD Sharing: YES. Countries: 1. Publications: 6.
A Study to Test the Effect of Different Doses of BI 685509 on Kidney Function in People With Diabetic Kidney Disease
ClinicalTrials.gov study NCT04750577. IPD Sharing: YES. Countries: 16. Publications: 1.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.