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1,368 results for “kidney transplantation”
Safety, Pharmacokinetics, and Preliminary Efficacy of Isatuximab in Patients Awaiting Kidney Transplantation
ClinicalTrials.gov study NCT04294459. IPD Sharing: YES. Countries: 2. Publications: 2.
Clazakizumab for the Treatment of Chronic Active Antibody Mediated Rejection in Kidney Transplant Recipients
ClinicalTrials.gov study NCT03744910. IPD Sharing: YES. Countries: 15. Publications: 4.
A Multicenter Study to Evaluate the Efficacy and Safety of Cinryze® for the Treatment of Acute Antibody-mediated Rejection in Participants With Kidney Transplant
ClinicalTrials.gov study NCT02547220. IPD Sharing: YES. Countries: 6. Publications: 1.
Preemptive Treatment With Grazoprevir and Elbasvir for Donor HCV Positive to Recipient HCV Negative Kidney Transplant
ClinicalTrials.gov study NCT02945150. IPD Sharing: YES. Countries: 1. Publications: 1.
Influence of polymorphisms in the vascular endothelial growth factor gene on allograft rejection after kidney transplantation: a meta-analysis
<p><span><b><i>Purpose</i></b><i> </i>Reported associations of allograft rejection in kidney transplant patients with <i>VEGF</i> single nucleotide polymorphisms (SNPs) have been inconsistent between studies, which prompted a meta-analysis to obtain more precise estimates.</span></p> <p><span><b><i>Methods</i></b><i> </i>Using the PICO elements, kidney transplant patients (P) were compared by genotype data between rejectors (I) and non-rejectors (C) in order to determine the risk of allograft rejection (O) attributed to the <i>VEGF</i> SNPs. Literature search of four databases yielded seven articles. To calculate risks for allograft rejection, four SNPs were examined. Meta-analysis treatments included outlier and subgroup analyses, the latter was based on ethnicity (Indians/Caucasians) and rejection type (acute/chronic). Multiple comparisons were corrected with the Bonferroni test. </span></p> <p><span><span><b><i>Results</i></b> Five highly significant outcomes (P<sup>a</sup> < 0.01) survived Bonferroni correction, one of which showed reduced risk for the <i>var</i> allele (OR 0.61, 95% CI 0.45-0.82). The remaining four indicated increased risk for the <i>wt</i> allele where the chronic rejection (OR 2.10, 95% CI 1.36-3.24) and Indian (OR 1.44, 95% CI 1.13-1.84) subgroups were accorded susceptibility status. </span></span></p> <p><span><b><i>Conclusions</i></b> Risk associations for renal allograft rejection were increased and reduced on account of the <i>wt</i> and <i>var</i> alleles, respectively. These findings could render the <i>VEGF</i> polymorphisms useful in the clinical genetics of kidney transplantation. </span></p>
Regulatory T cell therapy is associated with distinct immune regulatory lymphocytic infiltrates in kidney transplants: Spatial transcriptomic dataset and images
<p>The outputs of the NanoString GeoMx DSP platform were concatenated into three xlsx files, each illustrating a separate experiment along with their sample annotations. This technique analyzes protein or RNA abundance within regions of interest (ROIs) or specific cell segments selected based on histological features and immunofluorescence. In this repository, the concatenated GeoMx output files are presented, along with PowerPoint presentations for each biopsy that show immunofluorescence images of the selected ROIs and/or cell segments.</p> <ul> <li><strong>Protein_Full ROI:</strong> This experiment measured the abundance of 41 proteins in discrete regions of interest (ROIs) within transplant kidney biopsies.</li> <li><strong>Protein_Rare cell:</strong> This experiment measured the abundance of 40 proteins in specific cell segments, such as CD4+FoxP3- cells vs. CD4+FoxP3+ cells, within transplant kidney biopsies.</li> <li><strong>RNA:</strong> This experiment measured the abundance of 90 genes in discrete ROIs within transplant kidney biopsies.</li> </ul>
Kidney transplantation waiting times and risk of cardiovascular events and mortality: a retrospective observational cohort study in Taiwan
<p>Objectives: Patients with end-stage renal disease (ESRD) are at a high risk of cardiovascular events (CVEs), and kidney transplantation (KT) has been reported to improve risk of CVEs and survival. As the association of KT timing on long-term survival and clinical outcomes remains unclear, we investigated the association of different KT waiting times on clinical outcomes.</p> <p>Design: Retrospective observational cohort study.</p> <p>Setting: We conducted an observational cohort study using data from the National Health Insurance Research Database in Taiwan. Adult patients who initiated kidney transplantation therapy from 1997 to 2013 were included.</p> <p>Participants: A total of 3562 adult patients who initiated uncomplicated KT therapy were included and categorized into four groups according to KT waiting times after ESRD: Group 1 (<1 year), Group 2 (1–3 years), Group 3 (3–6 years), and Group 4 (>6 years).</p> <p>Primary outcome measure: The main outcome was a composite of all-cause death, nonfatal myocardial infarction, or nonfatal stroke, based on the primary diagnosis in medical records during hospitalization.</p> <p>Results: Compared with Group 1, the adjusted risk of primary outcome events (all-cause death, nonfatal myocardial infarction, or nonfatal stroke) increased by 1.67 times in Group 2 (95% CI: 1.40–2.00; P <0.001), 2.17 times in Group 3 (95% CI: 1.73–2.71; P <0.001), and 3.10 times in Group 4 (95% CI: 2.21–4.35; P <0.001). The rates of primary outcome events were 6.7%, 13.4%, and 14.0% within five years, increasing to 19.5%, 26.3%, and 30.8% within 10 years in Groups 1, 2, and 3, respectively.</p> <p>Conclusions: Our results demonstrate that early KT is associated with superior long-term cardiovascular outcomes compared to late KT in selected ESRD patients receiving uncomplicated KT, suggesting that an early KT could be a better treatment option for ESRD patients who are eligible for transplantation.</p>
Analysis results for association study of long-term kidney transplant rejection using whole-exome sequencing
<p>Association study results for long-term kidney transplant rejection. Single-variant association results are provided as Plink output files. Meta-analysis results are provided as METAL output files. FDR results are sorted lists of the top association result from random sample label permutations and are included with the plink and meta-analysis results. SKAT and GSEA results are provided for gene and pathway level analyses, respectively.</p>
HLA epitopic mismatch and risk of developing Donor Specific Antibodies in pediatric kidney transplantation
<p>The aim of this study was to evaluate the correlation between epitopic HLA mismatches and the risk of developing DSA in pediatric kidney recipients. There are very few publications concerning epitope HLA mismatch in pediatric kidney transplantation although this topic has been growing in scientific articles in recent years and is promising in adult recipients. The majority of children with chronic renal failure will require multiple kidney transplants during their lifetime and it is therefore important that we can limit the risk of antibody development in order to give them the best chance of survival for their future kidney transplants.</p>
Can Dapagliflozin Preserve Structure and Function in Transplanted Kidneys?
ClinicalTrials.gov study NCT05788276. IPD Sharing: NO. Countries: 1. Publications: 0.
A Study to Assess the Pharmacokinetics of a Modified-release Tacrolimus Based Immunosuppression Regimen in Stable Kidney Transplant Patients
ClinicalTrials.gov study NCT00282568. IPD Sharing: Not stated. Countries: 2. Publications: 2.
Comparison of Tacrolimus Extended-Release (Envarsus XR) to Tacrolimus Immediate-Release in Human Leukocyte Antigen (HLA) Sensitized Kidney Transplant Recipients
ClinicalTrials.gov study NCT04225988. IPD Sharing: NO. Countries: 1. Publications: 9.
Ides in Highly Sensitized (HS) Patients Awaiting Kidney Transplantation
ClinicalTrials.gov study NCT02426684. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Perioperative Aminophylline to Improve Early Kidney Function After a Kidney Transplant
ClinicalTrials.gov study NCT01759862. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Non-inferiority Study of Safety and Efficacy of Everolimus With Low Dose Tacrolimus to Mycophenolate Mofetil With Standard Dose Tacrolimus in Kidney Transplant Recipients
ClinicalTrials.gov study NCT01025817. IPD Sharing: Not stated. Countries: 2. Publications: 1.
ValGanciclovir Versus ValAcyclovir for Viral Prophylaxis in Kidney Transplantation
ClinicalTrials.gov study NCT01972035. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Safety Study of Lisinopril in Children and Adolescents With a Kidney Transplant
ClinicalTrials.gov study NCT01491919. IPD Sharing: Not stated. Countries: 1. Publications: 32.
Janssen Ad26.CoV2.S Vaccine Booster in Kidney Transplant Recipients
ClinicalTrials.gov study NCT05220397. IPD Sharing: NO. Countries: 1. Publications: 1.
Belatacept to Prevent Organ Rejection in Kidney Transplant Patients
ClinicalTrials.gov study NCT00346151. IPD Sharing: YES. Countries: 1. Publications: 1.
Sirolimus and Thymoglobulin to Prevent Kidney Transplant Rejection
ClinicalTrials.gov study NCT00006178. IPD Sharing: Not stated. Countries: 1. Publications: 3.
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.