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1,924 results for “knee osteoarthritis”
Patient reported outcome measures, load-induced blood marker kinetics, and ambulatory knee load in patients with medial compartment knee osteoarthritis
<p>The goal of this study was (i) to quantify the mechanoresponse of this array of potential blood markers for joint pathology (COMP, MMP-1, MMP-3, MMP-9, CPII, C2C, C2C/CPII, ADAMTS-4, PRG-4, IL-6 and resistin) to a walking stress test in patients with knee OA and to determine the correlation (ii) among the kinetics of these blood markers, (iii) with accumulated knee load during the walking stress, and (iv) with patient reported osteoarthritis outcome and QoL.</p> <p>The dataset includes 24 patients with knee osteoarthritis scheduled to receive high tibial osteotomy. All participants completed questionnaires, and a walking stress test with six blood samples analyzed using enzyme-linked immunosorbent assays for cartilage oligomeric matrix protein (COMP), matrix metalloproteinases (MMP)-1, -3, and -9, epitope resulting from cleavage of type II collagen by collagenases (C2C), type II procollagen (CPII), interleukin (IL)-6, proteoglycan (PRG)-4, A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-4, and resistin, and gait analysis. Joint load was computed from gait analysis data and musculoskeletal modelling in AnyBody Modeling System (AnyBody Technology A/S). Discrete loading parameters were extracted for each step using an inhouse algorithm written in Matlab.</p> <p>The detailed experimental protocol of the umbrella study has been described in Mündermann A, Vach W, Pagenstert G, Egloff C, Nüesch C. Assessing in vivo articular cartilage mechanosensitivity as outcome of high tibial osteotomy in patients with medial compartment osteoarthritis: Experimental protocol. Osteoarthr Cartil Open. 2020 Feb 24;2(2):100043. doi: 10.1016/j.ocarto.2020.100043. PMID: 36474590; PMCID: PMC9718245. The study is registered on clinicaltrials.gov (identifier NCT02622204). The method for computing joint loading has been described in detail in De Pieri E, Nüesch C, Pagenstert G, Viehweger E, Egloff C, Mündermann A. High tibial osteotomy effectively redistributes compressive knee loads during walking. J Orthop Res. 2022 Jun 22. doi: 10.1002/jor.25403. Epub ahead of print. PMID: 35730475.</p>
Surface electromyography data set of knee osteoarthritis patients undergoing hydrotherapy and physiotherapy rehabilitation routines
<p>Osteoarthritis is one of the most prevalent degenerative diseases in the elderly that affects the structural and functional integrity of the musculoskeletal system. Currently, hydrotherapy is taking relevance for osteoarthritis treatment due to its possible efficacy on pain relief and functionality. This therapy can be evaluated by means of an electromyographic analysis. The objective is to show a database of lower limbs muscles electrical activity in charge of postural stability, comparing the difference between hydrotherapy and conventional therapy through surface electromyography. A signal acquisition methodology was developed measuring electromyographic activity of the Tibialis Anterior, Soleus, Vastus Medialis, Biceps Femoris, Medial Gastrocnemius and Lateral Gastrocnemius muscles, before and after applying a specific exercise routine for knee osteoarthritis. This routine consisted of 12 therapy sessions spread over 4 weeks and could be done in water and on land. </p> <p>The data is organized according to the attendance of 28 patients to the therapy sessions. There are two records per person, before and after each hydrotherapy or physiotherapy session, obtaining a total of 1344 records at the end of the 12 sessions, and 56 data for each session. However, a total of 864 complete records were obtained for both therapies, withdrawing those who missed any of the sessions. There is a personal information database in .CSV format and electromyographic records with a .MAT extension.</p>
Implementing Group Physical Therapy (PT) for Veterans With Knee Osteoarthritis (Group PT): Function QUERI 2.0
ClinicalTrials.gov study NCT05282927. IPD Sharing: YES. Countries: 1. Publications: 3.
Randomized Study of the Efficacy and Safety of a Single Dose of Synvisc-One® in Chinese Patients With Symptomatic Osteoarthritis of the Knee
ClinicalTrials.gov study NCT03190369. IPD Sharing: YES. Countries: 1. Publications: 1.
A Study to Evaluate the Safety and Efficacy of CNTX-6970 in Subjects With Knee Osteoarthritis Pain.
ClinicalTrials.gov study NCT05025787. IPD Sharing: YES. Countries: 1. Publications: 58.
Study of Efficacy, Safety, and Tolerability of LNA043 in Patients With Knee Osteoarthritis
ClinicalTrials.gov study NCT04864392. IPD Sharing: YES. Countries: 15. Publications: 1.
Two Standardized Radial Pressure Wave Techniques Versus Pain-Site Guided Therapy in Patients With Knee Osteoarthritis.
ClinicalTrials.gov study NCT06622512. IPD Sharing: YES. Countries: 1. Publications: 13.
Effect Of Pulsed Electromagnetic Field And Microwave Therapy On Pain And Physical Function In Older Adults With Knee Osteoarthritis: A Randomized Clinical Trial.
<p><strong><span>Background and purpose:</span></strong><span> </span><span>Pulsed electromagnetic field (PEMF) therapy and microwaves (MW) are two electrotherapy modalities that have shown to improve pain and function in patients with knee osteoarthritis (KOA). Nevertheless, the effectiveness of these therapies is controversial due to diversity in the application parameters and treatment protocols in these patients. The objective is to compare the effectiveness of active PEMF versus MW, as well as sham PEMF, in addressing pain and improving functionality for treating KOA.</span></p> <p><strong><span>Methods:</span></strong><span> </span><span>Double-blind, placebo-controlled, randomized clinical trial. Participants diagnosed with KOA were assigned to an intervention combining an exercise program with active PEMF, MW, or sham PEMF, delivered in three weekly sessions over four weeks. The main outcomes were pain, reported on a 0–10 cm visual analogue scale (VAS), and functionality, as evaluated with the Western Ontario and McMaster Universities Arthritis (WOMAC) questionnaire, and the Timed Up and Go test. The outcomes were measured at pre-intervention, immediately post-intervention, and one and four months after the intervention.</span></p>
Treatment of Knee Osteoarthritis With Autologous Mesenchymal Stem Cells
ClinicalTrials.gov study NCT01183728. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Yoga as an Intervention for Women With Knee Osteoarthritis
ClinicalTrials.gov study NCT02146105. IPD Sharing: Not stated. Countries: 1. Publications: 1.
BOTOX® Efficacy and Safety in the Treatment of Knee Osteoarthritis
ClinicalTrials.gov study NCT02230956. IPD Sharing: Not stated. Countries: 3. Publications: 1.
Knee Biofeedback Rehabilitation Interface for Game-based Home Therapy for Patients With Knee Osteoarthritis
ClinicalTrials.gov study NCT04187092. IPD Sharing: NO. Countries: 1. Publications: 58.
Efficacy Study of Shortwave Diathermy for the Treatment of Patients With Knee Osteoarthritis
ClinicalTrials.gov study NCT00199914. IPD Sharing: NO. Countries: 1. Publications: 1.
Self-Administered Transcranial Direct Current Stimulation for Pain in Older Adults With Knee Osteoarthritis
ClinicalTrials.gov study NCT04016272. IPD Sharing: NO. Countries: 1. Publications: 3.
Neuropathic Pain in Knee Osteoarthritis: Pain Severity and Functional Status
ClinicalTrials.gov study NCT07367126. IPD Sharing: YES. Countries: 1. Publications: 6.
Effect of Footwear on the Clinical, Functional, and Biomechanical Aspects in Elderly Women With Knee Osteoarthritis (OA)
ClinicalTrials.gov study NCT01342458. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Efficacy and Safety of Oral Salmon Calcitonin in Patients With Knee Osteoarthritis (OA 2 Study)
ClinicalTrials.gov study NCT00704847. IPD Sharing: Not stated. Countries: 10. Publications: 5.
Efficacy and Safety of XT-150 in Osteoarthritis of the Knee
ClinicalTrials.gov study NCT04124042. IPD Sharing: NO. Countries: 2. Publications: 1.
A Study of the Safety and Efficacy of Hylan G-F 20 (Synvisc) in Patients With Symptomatic Osteoarthritis of the Knee
ClinicalTrials.gov study NCT00131352. IPD Sharing: Not stated. Countries: 6. Publications: 1.
Efficacy of Micro-fragmented Adipose Tissue Injection for Knee Osteoarthritis.
ClinicalTrials.gov study NCT03379168. IPD Sharing: NO. Countries: 1. Publications: 24.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.