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22 results for “lactate dehydrogenase”
Data from: Biochemical, structural and dynamical characterizations of the lactate dehydrogenase from Selenomonas ruminantium provide information about an intermediate evolutionary step prior to complete allosteric regulation acquisition in the super family of lactate and malate dehydrogenases.
<p>This data accompanies the paper entitled <strong><em>Biochemical, structural and dynamical characterizations of the lactate dehydrogenase from Selenomonas ruminantium provide information about an intermediate evolutionary step prior to complete allosteric regulation acquisition in the super family of lactate and malate dehydrogenases.</em></strong></p> <p>The zip archive contains the results of molecular dynamics simulations of the 2 systems investigated in the paper: <em>S. rum</em> and <em>T. mar</em> LDHs. The systems have been simulated at 315 K for <em>S. rum </em>and 340 K for <em>T. mar</em>. Final configurations of the proteins after productions are provided for all the systems in GRO Gromos87 format. Trajectories with the positions of the proteins every 100 ps are provided for all the systems in XTC gromacs format.</p>
Data from: Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies
<p>The astrocyte-neuron lactate shuttle hypothesis posits that glial-generated lactate is transported to neurons to fuel metabolic processes required for long-term memory. Although studies in vertebrates have revealed that lactate shuttling is important for cognitive function, it is uncertain if this form of metabolic coupling is conserved in invertebrates or is influenced by age. Lactate dehydrogenase (Ldh) is a rate-limiting enzyme that interconverts lactate and pyruvate. Here we genetically manipulated expression of <em>Drosophila</em> <em>melanogaster</em> lactate dehydrogenase (dLdh) in neurons or glia to assess the impact of altered lactate metabolism on invertebrate aging and long-term courtship memory at different ages. We also assessed survival, negative geotaxis, brain-neutral lipids (the core component of lipid droplets), and whole head metabolites. Both upregulation and downregulation of dLdh in neurons resulted in decreased survival and memory impairment with age. Glial downregulation of dLdh expression caused age-related memory impairment without altering survival, while upregulated glial dLdh expression lowered survival without disrupting memory. Both neuronal and glial dLdh upregulation increased neutral lipid accumulation. We provide evidence that altered lactate metabolism with age affects the tricarboxylic acid (TCA) cycle, 2-hydroxyglutarate (2HG), and neutral lipid accumulation. Collectively, our findings indicate that the direct alteration of lactate metabolism in either glia or neurons affects memory and survival but only in an age-dependent manner. </p>
Data from: Aging and memory are altered by genetically manipulating lactate dehydrogenase in the neurons or glia of flies
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Ectopic expression of murine CD163 enables cell-culture isolation of lactate dehydrogenase-elevating (LDV) virus 63 years after its discovery
<p><span>Arteriviruses are RNA viruses related to coronaviruses but have not yet been associated with human infection. A murine arterivirus (lactate dehydrogenase-elevating virus, LDV) was first described in 1960 and quickly became a promising model for understanding immune failure due to its unique ability to persist in immunocompetent adult mice. However, inability to culture LDV <em>in vitro</em> ultimately limited this system. Here, we demonstrate that the macrophage marker CD163 is essential for LDV infection. Expression of the murine homolog (mCD163) in otherwise mCD163-negative cell lines from mice and nonhuman primates enables productive LDV infection, creating the first immortalized cell-culture system. We also show that mCD163-knockout mice are completely resistant to LDV infection. These findings advance LDV as a model of arterivirus infection viral persistence and add to a growing body of literature suggesting that CD163 utilization is a broad feature of arteriviruses.</span></p>
A Method for Differentiating Sepsis and Septic Shock Based on Phenylalanine Hydroxylase and Lactate Dehydrogenase Activity
<p>The present method relates to improving the prognosis, diagnosis, and treatment of sepsis and septic shock. Despite the availability of advanced treatment, sepsis, and septic shock have the highest mortality in the intensive care unit (ICU). Theories suggested that hyperinflammation is a major characteristic of septic shock, but oxidative stress plays a major role in disease pathogenesis. Nuclear Magnetic Resonance (NMR) spectroscopy-based quantitative assessment of metabolites was performed to compare the activity of lactate dehydrogenase and phenylalanine hydroxylase between sepsis, septic shock, and disease control in sepsis and septic shock by comparing pyruvate/lactate (Pyr/Lac) and phenylalanine/tyrosine (Phe/Tyr) ratios. These ratios were evaluated and found to be used as an effective tool for diagnosis, prognosis, evaluation of disease activity, and treatment response.</p> <p> </p>
Chemotherapy Intensification in Patients With High Lactate Dehydrogenase Values and Soluble Syndecan1 Levels
ClinicalTrials.gov study NCT03117972. IPD Sharing: NO. Countries: 1. Publications: 1.
Evaluation of Lactate Dehydrogenase as Decision Support for Admissions to Neonatal Ward
ClinicalTrials.gov study NCT02379936. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Data from: The adaptive cline at Ldh (lactate dehydrogenase) in killifish Fundulus heteroclitus remains stationary after 40 years of warming estuaries
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Ectopic expression of murine CD163 enables cell-culture isolation of lactate dehydrogenase-elevating (LDV) virus 63 years after its discovery
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Data from: Peroxisomal lactate dehydrogenase is generated by basal translational readthrough in mammals
Translational readthrough gives rise to low abundance proteins with C-terminal extensions beyond the stop codon. To identify functional translational readthrough, we estimated the readthrough propensity (RTP) of all stop codon contexts of the human genome by a new regression model in silico, identified a nucleotide consensus motif for high RTP by using this model, and analyzed all readthrough extensions in silico with a new predictor for peroxisomal targeting signal type 1 (PTS1). Lactate dehydrogenase B (LDHB) showed the highest combined RTP and PTS1 probability. Experimentally we show that at least 1.6% of the total cellular LDHB getting targeted to the peroxisome by a conserved hidden PTS1. The readthrough-extended lactate dehydrogenase subunit LDHBx can also co-import LDHA, the other LDH subunit into peroxisomes. Peroxisomal LDH is conserved in mammals and likely contributes to redox equivalent regeneration in peroxisomes.
Data from: Peroxisomal lactate dehydrogenase is generated by basal translational readthrough in mammals
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Increased lactate dehydrogenase activity is dispensable in squamous carcinoma cells of origin
GEO Series GSE111997. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome analysis and weighted gene co-expression network reveal candidate genes and pathways responses to lactate dehydrogenase inhibition (oxamate) in hyperglycemic human renal proximal epithel
GEO Series GSE182138. Homo sapiens. 5 samples. Type: Expression profiling by high throughput sequencing.
Lactate dehydrogenase inhibition synergizes with IL-21 to promote CD8+ T cell stemness and antitumor immunity
GEO Series GSE143903. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Comparative efficacy of serum lactate dehydrogenase levels versus circulating cell-free microRNAs in monitoring response to checkpoint inhibitor immunotherapy treatment in metastatic melanoma patients
GEO Series GSE157370. Homo sapiens. 7 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Macrophage-Specific Lactate Dehydrogenase Expression Modulates Inflammatory Function In Vitro
GEO Series GSE277304. Mus musculus. 18 samples. Type: Expression profiling by high throughput sequencing.
Comparison of RNA expression between Drosophila Lactate Dehydrogenase mutants and controls
GEO Series GSE119334. Drosophila melanogaster. 8 samples. Type: Expression profiling by high throughput sequencing.
Lactate dehydrogenase B noncanonically promotes ferroptosis defense in KRAS-driven lung cancer
GEO Series GSE224098. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Cancer Ratio,Pleural Fluid Adenosine Deaminase,Lactate Dehydrogenase, interferonY, Tumor Necrosis Factor,and Interleukins{2,12,18}for Differentiation Between Malignant and Non Malignant Pleural Effusi
ClinicalTrials.gov study NCT05693727. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Level of Serum Lactate Dehydrogenase in Immune Thrombocytopenia
ClinicalTrials.gov study NCT07046013. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
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