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Dataset results
13 results for “laterality defects.”
The LAVA mutants defective in auxin-regulated primary or lateral root development.
<p><span>Regulation of PIN activity, polarity as well as auxin gradient generation and its canalisation remain crucial topics in plant developmental biology especially in the context of organogenesis like the formation new lateral roots. Here, we are presenting the LAVA (LR Alterations Visualised after Auxin) collection of 278 mutants, defective in auxin-induced lateral root (LR) morphogenesis. Those mutants were obtained from a forward genetic screen in which synthetic auxin 1-Naphtyl Acetic Acid (1-NAA) was used to induce LR formation in the mutagenized PIN3::PIN3-GFP population. Our database contains mutant root phenotyping and for a subset of the collection, we recorded PIN polarity and subcellular trafficking, cotyledon vasculature development, primary and LR gravitropism as well as aerial phenotypes with some reminiscent to auxin-regulated organogenesis aberrations. We are convinced that our dataset can serve as a unique tool to identify novel components of auxin signalling, transport, and cell polarity but also be of interest to the broader plant research community interested in the roots system architecture that is vital for plant survival, growth and adaptation to environmental conditions.</span></p> <p><span>The phenotype analysis of the mutant collection is summarized and organised in an Excel spreadsheet (2024-08-07_mutant_database_Table S1). The photographic material is organised in folder form (see Supporting Data S1 in this repository), where each folder number corresponds to a particular mutant and entry in the excel table.</span></p> <p><span> Mutant seeds will be available in the European Arabidopsis Stock Centre (NASC). The seed sending to the repository is in progress. </span></p> <p><span>The manuscript describing this work is currently being submitted to the research journal. Its version will be available on the open access Masaryk University repository.</span></p>
Dataset related to article "Defective cyclophilin A induces TDP-43 proteinopathy: implications for amyotrophic lateral sclerosis and frontotemporal dementia"
<p>Dataset related to the article 10.1093/brain/awab333</p>
Buccal Fat for Transoral Robotic Lateral Oropharyngectomy Defects to and Postoperative Pain
ClinicalTrials.gov study NCT06965738. IPD Sharing: YES. Countries: 1. Publications: 1.
Lateral Arm Free Flap for Reconstruction of the Oral Cavity and Head and Neck Soft Tissue Defects.
ClinicalTrials.gov study NCT05296811. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Use of ST250 to Reconstruct Lateral Tongue Defects
ClinicalTrials.gov study NCT06988449. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Lateral Supramalleolar Perforator Flap Reconstruction Through Branches Outside of the Ankle Tissue Defects
ClinicalTrials.gov study NCT04687345. IPD Sharing: Not stated. Countries: 0. Publications: 3.
Variability of an early developmental cell population underlies stochastic laterality defects
GEO Series GSE153621. Danio rerio. 48 samples. Type: Expression profiling by high throughput sequencing.
The Laterally Closed Tunnel Versus Modified Coronally Advanced Tunnel for Mandibular Anterior Gingival Recession Defects
ClinicalTrials.gov study NCT04198376. IPD Sharing: NO. Countries: 1. Publications: 0.
Microsurgical Instruments and Magnification May Enhance Treatment Outcomes Of Laterally Moved, Coronally Advanced Flap in Miller Class III Isolated Recession Defects
ClinicalTrials.gov study NCT02281071. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Does Surgical Treatment of Cartilage Defects Prevent Osteoarthritis in Later Life?
ClinicalTrials.gov study NCT07320118. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Lateral Vaginal Wall Site-specific Defect Reconstructions
ClinicalTrials.gov study NCT04635514. IPD Sharing: UNDECIDED. Countries: 0. Publications: 0.
Characteristics and outcomes of fetuses with laterality defects are the current outcomes better? A single center study
<p>Dataset from Fesslova V, Pluchinotta F, Brankovic J, Boschetto C, Piazza L, Inversetti A, Sigismondi C, Giorgione V, Frigiola A. Characteristics and outcomes of fetuses with laterality defects are the current outcomes better? A single center study. J Matern Fetal Neonatal Med. 2021 Feb;34(4):547-554. doi: 10.1080/14767058.2019.1610737. Epub 2019 May 20. PMID: 31106637.</p> <p>Abstract</p> <p><strong>Objective<em>:</em></strong> To analyze the more recent outcomes of fetuses with different laterality defects.<strong>Material and methods:</strong> Out of 1508 fetuses with congenital heart disease (CHD) diagnosed by echocardiography between January 1995 and December 2015, 94 (6.3%) presented abnormal visceroatrial situs: 42 till December 2002 (group 1, analyzed retrospectively) and 52 since then until December 2015 (group 2, analyzed prospectively). Twenty-one had left isomerism (Lisom), 22 right isomerism (Risom), 16 situs inversus- dextrocardia (SVI-dx), 5 situs inversus- levocardia (SVI-levo), and 30 situs solitus-dextrocardia (SSol-dx).<strong>Results:</strong> Seventy-six cases (81%) had CHD, more frequently complex atrioventricular defect. Eighteen cases showed normal heart: half of subgroups SVI-dx and SVI-levo, a third of SSol-dx. Postoperative mortality in continuing pregnancy in group 2 was 43.7 versus 40% in group 1, lower in SVs-dx (0 versus 50%) and Lisom (33.3 versus 66.7%), worse in Risom (71.4 versus 25%). Total mortality in group 2 was 48.3 versus 55% in group 1, better in Ssol-dx (37.5 versus 50%) and in Lisom (27.4 versus 71.4%). In isolated forms all but one case are alive.<strong>Conclusions:</strong> Our fetal cases presented a relevant mortality in both periods. The outcomes were slightly better in a more recent era in SSol and Lisom.What is known about this topic?Out of laterality defects, the heterotaxies (i.e. left and right isomerism) are known to be associated to a relevant mortality in fetal and neonatal cases.Heterotaxies have a variable position of the heart, but some authors evaluated only those with dextrocardia in their studies on different laterality defects.Controversial data are presented in the literature for the outcomes of fetuses with laterality defects. Many large studies analyzed the data of a very long time period in which it is opinable to compare the results of the treatment, because of a recent improved management and surgical techniques.What does this study add?Our study presents an experience of a single center with cases of different types of laterality defects observed during a routine fetal echocardiography, not only heterotaxies.The knowledge of different laterality defects and of their characteristics (association with cardiac and extracardiac anomalies or with normal heart) is useful for the prenatal counseling.We compare the postoperative and total mortality in more recent period (since 2003) with respect to the previous era (1995-2002).</p>
Kids First: Genomic Analysis of Laterality Birth Defects
Namespace hosted on the Kids First DRC FHIR services at fhir.kidsfirstdrc.org
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