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13
datasets available to search
ShareScore release 0.9.0
Dataset results
13 results for “left atrial strain”
Aladdin: High-Resolution Maps of Left Atrial Displacements and Strains Estimated with 3D Cine MRI
<p>The uploaded files include high-resolution 3D images of the left atrium from 18 individuals—10 healthy volunteers and 8 patients with various cardiovascular diseases—along with their corresponding left atrium segmentation maps. Additionally, a deformation atlas based on the 10 healthy cases is also provided.</p> <p>For more information, visit: <a href="https://github.com/cgalaz01/aladdin_cmr_la" target="_new" rel="noopener">https://github.com/cgalaz01/aladdin_cmr_la</a></p>
Left Atrial Strain and Cryptogenic Stroke
ClinicalTrials.gov study NCT07224178. IPD Sharing: YES. Countries: 1. Publications: 10.
Left Atrial Strain Values as an Early Predictor of Atrial Fibrillation
ClinicalTrials.gov study NCT06417112. IPD Sharing: UNDECIDED. Countries: 1. Publications: 31.
Left Atrial Strain and Supraventricular Arrhythmia Burden in Cardiac Light Chain Amyloidosis Following Chemotherapy
ClinicalTrials.gov study NCT05448716. IPD Sharing: UNDECIDED. Countries: 1. Publications: 4.
Relative Importance of Cardiovascular Risk Factors and Echocardiographic Parameters Affecting Left Atrial Strain
ClinicalTrials.gov study NCT05638230. IPD Sharing: NO. Countries: 1. Publications: 1.
Genome-wide analysis of atrial left-right differences in two different mouse strains
GEO Series GSE29500. Mus musculus. 16 samples. Type: Expression profiling by array.
Normal Values for Myocardial Left Atrial Strain
ClinicalTrials.gov study NCT03874624. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Left Atrial Strain Assessment in Ischemic Stroke Patients
ClinicalTrials.gov study NCT07102693. IPD Sharing: YES. Countries: 1. Publications: 0.
LA-HCM Study : Rivaroxaban for Antithrombotic Prevention in Hypertrophic Cardiomyopathy Patients With Abnormal Left Atrial Strain.
ClinicalTrials.gov study NCT07202897. IPD Sharing: Not stated. Countries: 0. Publications: 0.
Prognostic value of left atrial strain quantification from 2D ultrasound imaging in post-ischemic heart failure patients: evidence from the REMODEL-HF study.
<p>Frigelli M, Sturla F, Milani V, Ramputi L, Citarella M, Menicanti L, Votta E, Castelvecchio S. Prognostic value of left atrial strain quantification from 2D ultrasound imaging in post-ischemic heart failure patients: evidence from the REMODEL-HF study. Int J Cardiol. 2022 Sep 1;362:183-189. doi: 10.1016/j.ijcard.2022.04.071. Epub 2022 Apr 30. PMID: 35504452.</p> <p>Abstract</p> <p><strong>Background: </strong>Left atrial (LA) function can be effectively assessed by measuring longitudinal LA strain (LAS) via two-dimensional speckle tracking echocardiography (2DSTE). Here, we test 2DSTE-based LAS as marker of different left ventricle (LV) remodeling patterns and as prognostic index in ischemic heart failure (HF) candidates to surgical ventricular reconstruction.</p> <p><strong>Methods: </strong>We retrospectively considered ischemic HF patients with anterior (group A, n=130) or posterior (group P, n=48) LV remodeling. Based on 2D ultrasound, LV and LA morpho-functional parameters were quantified including reservoir (LAS<sub>Res</sub>), conduit (LAS<sub>Cond</sub>) and booster (LAS<sub>Boost</sub>) LAS. We tested their capability to discriminate between groups A and P, and their group-specific prognostic significance for the composite end-point of death or HF re-hospitalization at follow-up (mean follow-up time=40 months, range 3-101 months).</p> <p><strong>Results: </strong>Group A and group P displayed similar end-diastolic (p=0.89) and end-systolic (p=0.33) LV volume index, and LA volume index LAVi (p=0.44) corrected for the degree of mitral regurgitation. As compared to group P, group A revealed a significant reduction in LAS<sub>Boost</sub> (9.2±0.4% vs. 11.1±0.7%, p=0.04) and a non-significant reduction in LAS<sub>Res</sub> (16.9±0.7% vs. 19.3±1.1%, p=0.06). Kaplan-Meier curves showed that the median LAS<sub>Res</sub> and LAS<sub>Boost</sub> values effectively stratified patients based on their prognosis in the overall study population (Log-rank p=0.002 and Log_rank p<0.0001) and in group A, where the association was stronger for LAS<sub>Boost</sub> (Log-rank p<0.001) than for LAS<sub>Res</sub> (Log-rank p=0.013).</p> <p><strong>Conclusions: </strong>2DSTE-based LAS assessment is affordable, repeatable and non-invasive, and could add clinically-relevant mechanistic insight and prognostic value in the stratification of ischemic HF patients.</p>
Rapid Risk Stratification of Acute Ischemic Stroke Patients in the Emergency Department: The Incremental Prognostic Role of Left Atrial Reservoir Strain
<p><strong>Objectives</strong>: To determine the prognostic value of positive global left atrial strain (LA-GSA+), measured by two-dimensional speckle tracking echocardiography (2D-STE) in a population of acute ischemic stroke (AIS) patients without atrial fibrillation (AF), in the setting of Emergency Department (ED).</p> <p><strong>Methods</strong>: All consecutive AIS patients with sinus rhythm on ECG and without AF history entered this prospective study. All patients underwent complete blood tests and transthoracic echocardiography implemented with 2D-STE analysis of LA strain parameters within 6-12 hours after symptoms onset. At 6-months follow-up, we evaluated the composite endpoint of all-cause mortality plus cardiovascular re-hospitalizations.</p> <p><strong>Results</strong>: A total of 102 AIS patients (76.4±10.8 yrs, 47% males) were prospectively included. LA-GSA+ was markedly reduced in AIS patients (20.8±7.7%), without any statistically significant difference between the stroke subtypes. At 6-months follow-up, 7 deaths and 27 re-hospitalizations occurred. On multivariate Cox regression analysis, variables independently associated with outcome were: LA-GSA+ (per unit) (HR 0.29, 95% CI 0.19-0.39) and C-reactive protein (CRP) (per 0.1 mg/dl) (HR 1.45, 95% CI 1.15-1.75) as continuous variables; statin therapy (HR 0.45, 95%CI 0.28-0.62), and type 2 diabetes (HR 1.65, 95% CI 1.15-2.35) as categorical variables. A LA-GSA+ ≤20.0% predicted the occurrence of the above-mentioned outcome at 6-months follow-up with 94% sensitivity and 81% specificity (AUC=0.84). Interestingly, GSA+ showed a strong inverse correlation with CRP levels (r=-0.86).</p> <p><strong>Conclusions</strong>: A LA-GSA+ ≤20% reflects a more advanced atrial cardiomyopathy and might provide a rapid and reliable prognostic risk stratification of AIS patients without AF history in the setting of ED.</p>
Incremental prognostic role of left atrial reservoir strain in asymptomatic patients with moderate aortic stenosis
<p>Raw data related to the article</p> <p>Abstract<br> Left atrial (LA) mechanics assessed by two-dimensional speckle tracking echocardiography (2D-STE) have not been extensively<br> studied and clearly characterized in patients with moderate aortic stenosis (AS). Accordingly, we aimed to evaluate<br> the usefulness of LA reservoir strain for risk stratification of asymptomatic patients with moderate AS. This retrospective<br> study included all consecutive asymptomatic patients with moderate AS who underwent transthoracic echocardiography<br> implemented with 2D-STE analysis of LA myocardial strain and strain rate indices at our Institution, between February 2011<br> and September 2019. During the follow-up period, we evaluated the occurrence of any of the following: (1) CV hospitalization;<br> (2) The recourse to AS surgery; (3) Cardiac death or sudden death. A total of 186 patients (mean age 71.9 ± 12.7 years,<br> 61.8% men) were included in the present study. During a mean follow-up of 2.3 ± 1.9 years, no patients died and 63 adverse<br> CV events were recorded: 48 patients were hospitalized because of heart failure (28 patients), acute coronary syndrome (10<br> patients), arrhythmias (10 patients) and 15 patients underwent AS surgery. At the multivariate Cox regression analysis, type 2<br> diabetes mellitus (OR 1.87, 95%CI 1.05–3.34, p = 0.03), NT-proBNP (OR average 1.14, 95%CI 1.02–1.27, p = 0.02), average<br> E/e′ ratio (OR 1.07, 95%CI 1.01–1.15, p = 0.04) and most of all left atrial positive global strain (LA-GSA+) (OR 0.85, 95%CI<br> 0.81–0.90, p < 0.0001) were independently associated with the outcome. LA-GSA+ (optimal cut-off ≤ 19%, AUC = 0.94,<br> 87% sensitivity, 99% specificity, positive predictive value 99%, negative predictive value 88%) showed the highest diagnostic<br> performance. An impaired LA reservoir strain can contribute to identify a subset of asymptomatic patients with moderate<br> AS at higher risk, who may benefit from closer echocardiographic follow-up and/or early surgery.</p>
Incremental diagnostic role of left atrial strain analysis in thrombotic risk assessment of nonvalvular atrial fibrillation patients planned for electrical cardioversion
<p>Raw data related to the article</p> <p>Abstract<br> During the COVID-19 pandemic, transesophageal echocardiography (TEE) for left atrial appendage thrombosis (LAAT)<br> detection should be limited to situations of absolute necessity. We sought to identify the main conventional and functional<br> echocardiographic parameters associated with LAAT on TEE in non-valvular atrial fibrillation (NVAF) patients planned<br> for electrical cardioversion (ECV). This retrospective study included 125 consecutive NVAF patients (71.5±7.8 yrs, 75<br> males), who underwent TEE at our Institution between April 2016 and January 2020, to exclude LAAT before scheduled<br> ECV. All patients underwent a transthoracic echocardiography (TTE) implemented with speckle tracking echocardiography<br> (STE) analysis of left atrial (LA) strain and strain rate (SR) parameters. 28% of patients were diagnosed with LAAT, while<br> 72% without LAAT. Compared to controls, patients with LAAT had significantly higher CHA2DS2-<br> Vasc Score and average<br> E/e’ ratio, and significantly lower left ventricular ejection fraction (LVEF). Moreover, LA-peak positive global atrial strain<br> (GSA+) and LA-SR parameters were significantly reduced in patients with LAAT. Multivariate logistic regression revealed<br> that, differently from CHA2DS2-<br> Vasc Score, LVEF (OR 0.88, 95%CI 0.81–0.97, p = 0.01), average E/e’ ratio (OR 2.36,<br> 95%CI 1.41–3.98, p = 0.001), and LA-GSA+ (OR 0.57, 95%CI 0.36-0-90, p = 0.01) were independently associated with<br> LAAT. LA-GSA+ (optimal cut-off ≤ 9.1%, AUC 0.95) showed the highest diagnostic performance. Finally, a strong linear<br> correlation of LA peak-to-peak SR with both LA appendage filling (r = 0.86) and emptying (r = 0.83) velocities was demonstrated.<br> TTE implemented with STE analysis of LA mechanics improves thrombotic risk assessment of NVAF patients.</p>
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OpenNeuro
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