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219 results for “leishmaniasis”
scRNA-seq data for article: Kupffer cell and recruited macrophage heterogeneity orchestrate granuloma maturation and hepatic immunity in visceral leishmaniasis
<p>Single-cell RNA-seq dataset from sorted CD11bInt, F4/80Hi, CD64+ mouse liver cells in naive or Leishmania infantum-infected animals at 42 d.p.i.. Data analyses and results are described in manuscript: "Kupffer cell and recruited macrophage heterogeneity orchestrate granuloma maturation and hepatic immunity in visceral leishmaniasis". Data files are Seurat objects in RDS format. Filtered-out potential doublets, low quality cells and dying cells (excluded cells with <1000 genes detected, cells with >6000 genes detected, cells with mitochondrial gene expression > 10% and cells with <5000 transcript molecules). Data normalization, scaling and integration performed using Seurat.</p> <p>Filtered dataset containing all KCs and macrophages is in the "pessenda_KC_Macro_seurat" file.</p> <p>Our data were then mapped onto a reference dataset published by Remmerie et al. (DOI: 10.1016/j.immuni.2020.08.004) for annotation consistent with the literature. The reference mapped object can be found in the "pessenda_refmap_KC_Macro_seurat" file.</p> <p>Dataset containing the additional analysis of CLEC4F-TIM4+ FACS-sorted KCs can be found in the "pessenda_refmap_KCTimPos_seurat" file.</p>
Figure 3 in Leishmaniasis and phlebotomine sand flies in Oman Sultanate
Figure 3. (A) Professor Rioux and the field team in the Dhofar; (B) Ouadi Herwouib in the Dhofar labelled Dh6 in accordance with Figure 1 where Ph. bergeroti, Ph. alexandri, Se. tiberiadis and Se. fallax are the most abundant species. (C) the Sharqiyah around the Ouadi.
Figure 2 in Leishmaniasis and phlebotomine sand flies in Oman Sultanate
Figure 2. Map showing the sampling of phlebotomine sandflies, dogs, foxes and patients. Locations in the Sharqiyah are labelled Sh and those from the Dhofar are labelled Dh, in accordance with Figure 1.
Figure 2 in Spatial distribution and effects of land use and cover on cutaneous leishmaniasis vectors in the municipality of Paracambi, Rio de Janeiro, Brazil
Figure 2 Monthly mean relative abundance of medically relevant sand fly species. Please note the scale difference in the Y axis. Paracambi, RJ, Brazil, 1992-1994.
Fig. 2 in Leishmania presence in bats in areas endemic for leishmaniasis in centralwest Brazil
Fig. 2. Agarose gel demonstrating kDNA PCR products (120bp). M: 100bp marker. 1–17: analyzed samples, of which 2–11, 13 and 16 were considered positive. PC: positive control of Leishmania spp., NC: negative control.
Fig. 4 in Leishmania presence in bats in areas endemic for leishmaniasis in centralwest Brazil
Fig. 4. Identification of Leishmania according to site of collect of the bats per city, Mato Grosso do Sul, Brazil; Grey area - municipal boundary; A – Campo Grande; B – Corumbá; C – Ivinhema; D – Brasilândia.
Fig. 3 in Leishmania presence in bats in areas endemic for leishmaniasis in centralwest Brazil
Fig. 3. Agarose gel demonstrating LnPCR products (350bp). M: 100bp marker, 1–17: analyzed samples, of which 2, 7, 10 and 14 were considered positive. PC: positive control of Leishmania spp., NC: negative control.
Figure 2 in Variability Modeling of Rainfall, Deforestation, and Incidence of American Tegumentary Leishmaniasis in Orán, Argentina, 1985-2007
Figure 2. - Relation between cumulative trophic diversity and number of analyzed stomachs of Gaidropsarus guttatus from Faial Island, Azores.
Figure 3 in Variability Modeling of Rainfall, Deforestation, and Incidence of American Tegumentary Leishmaniasis in Orán, Argentina, 1985-2007
Figure 3. - Index of relative importance (%Rw) regarding the major prey items found in the stomachs of Gaidropsarus guttatus from Faial Island, Azores.
Figure 1 in Variability Modeling of Rainfall, Deforestation, and Incidence of American Tegumentary Leishmaniasis in Orán, Argentina, 1985-2007
Figure 1. - Map showing Faial, within the Azores Archipelago, NE Atlantic, and collection Gaidropsarus guttatus sites.
Quality of life for patients with cutaneous leishmaniasis: a comparative analysis of the EQ-5D-3L and CLIQ questionnaires.
<p>This dataset contains quality of life surveillance results for patients with cutaneous leishmaniasis, Brazil, focusing in a comparative analysis of the EQ-5D-3L and CLIQ questionnaires.</p>
DNDI-6174, a preclinical candidate for visceral leishmaniasis that targets the cytochrome bc1 complex – Figures 3 and S2-8 raw data
<p>New drugs for visceral leishmaniasis that are safe, low cost and adapted to the field are urgently required. Despite concerted efforts over the last several years, the number of new chemical entities with novel mechanisms of action that are suitable for clinical development remains low. Here, we describe the development of DNDI-6174, an inhibitor of <em>Leishmania</em> cytochrome b that originated from a phenotypically-identified pyrrolopyrimidine series. This compound fulfills all Target Candidate Profile criteria required for progression into preclinical development. In addition to good metabolic stability and pharmacokinetic properties, DNDI-6174 demonstrates potent in vitro activity against a variety of <em>Leishmania</em> species and can reduce parasite burden in animal models of infection, with potential for sterile cure. No significant flags were identified in preliminary safety studies, including an exploratory 14-day toxicology study in the rat. DNDI-6174 represents the first cytochrome b inhibitor to enter preclinical development for visceral leishmaniasis.</p>
Basophils as a predictive hematological biomarker of canine visceral leishmaniasis in the treatment with miltefosine
<p><strong>BACKGROUND:</strong> Basophils are initiators of the Th2 response related to the progression of canine visceral leishmaniasis (CanL). Miltefosine has been presented as an alternative in treatment due to its leishmanicide and immunomodulatory effects. Many blood cells have been used as predictive biomarkers, but none of them focused on the immunomodulatory action of miltefosine in the different stages of the disease.</p> <p><strong>OBJECTIVE:</strong> Identifying the predictive hematological biomarkers in dogs with visceral leishmaniasis treated with miltefosine.</p> <p><strong>METHODS:</strong> The animals were divided into three groups: sick dogs; infected dogs, dogs exposed. The animals were submitted to differential blood cell count and CanL diagnosis, through DPP, ELISA and qPCR. The groups were monitored from the time zero (T0) before treatment, and the times twenty (T20) and thirty (T30) days after the beginning of treatment using miltefosine at a dose of 1mL/10kg per day for 28 days.</p> <p><strong>FINDINGS:</strong> Basophils showed an exponential increase in the infected and sick group with an increase of IgG, suggesting a Th2 response. In the exposed group there was reduction of basophils with increase in monocytes and IgG reduction, suggesting a Th1 response.</p> <p><strong>CONCLUSIONS:</strong> We suggest basophils as a predictive biomarker of immunomodulation in the treatment of CanL with miltefosine.</p> <p><strong>BACKGROUND:</strong> Basophils are initiators of the Th2 response related to the progression of canine visceral leishmaniasis (CanL). Miltefosine has been presented as an alternative in treatment due to its leishmanicide and immunomodulatory effects. Many blood cells have been used as predictive biomarkers, but none of them focused on the immunomodulatory action of miltefosine in the different stages of the disease.</p> <p><strong>OBJECTIVE:</strong> Identifying the predictive hematological biomarkers in dogs with visceral leishmaniasis treated with miltefosine.</p> <p><strong>METHODS:</strong> The animals were divided into three groups: sick dogs; infected dogs, dogs exposed. The animals were submitted to differential blood cell count and CanL diagnosis, through DPP, ELISA and qPCR. The groups were monitored from the time zero (T0) before treatment, and the times twenty (T20) and thirty (T30) days after the beginning of treatment using miltefosine at a dose of 1mL/10kg per day for 28 days.</p> <p><strong>FINDINGS:</strong> Basophils showed an exponential increase in the infected and sick group with an increase of IgG, suggesting a Th2 response. In the exposed group there was reduction of basophils with increase in monocytes and IgG reduction, suggesting a Th1 response.</p> <p><strong>CONCLUSIONS:</strong> We suggest basophils as a predictive biomarker of immunomodulation in the treatment of CanL with miltefosine.</p>
Macrophage targeting of nitazoxanide-loaded transethosomal gel in cutaneous leishmaniasis
<p>Topical delivery is preferable over systemic delivery for cutaneous leishmaniasis (CL), because of its easy administration, reduced systemic adverse effects, and low cost. Nitazoxanide (NTZ) has broad-spectrum activity against various parasites and has the potential to avoid drug resistance developed by enzymatic mutations. NTZ oral formulation is being associated with severe dyspepsia and stomach pain. Herein, NTZ-transethosomes (NTZ-TES) were prepared and loaded into chitosan gel (NTZ-TEG) for topical delivery. NTZ-TES were prepared by thin-film-hydration method and optimized statistically via Box-Behnken method. The optimized formulation indicated excellent particle size (176 nm), PDI (0.093), zeta potential (-26.4 mV) and entrapment efficiency (EE, 86%). The TEM analysis showed spherical sized particles and FTIR analysis indicated no interaction among the excipients. Similarly, NTZ-TEG showed optimal pH, desirable viscosity and good spreadability. NTZ-TES and NTZ-TEG showed prolonged release behavior and higher skin penetration and deposition in epidermal/dermal layer of skin in comparison with the NTZ-dispersion. Moreover, NTZ-TES showed higher percentage inhibition, lower IC50 against promastigotes and higher macrophage uptake. Additionally, skin irritation and histopathology studies indicated the safe and non-irritant behavior of the NTZ-TEG. The obtained findings suggested the enhanced skin permeation and improved anti-leishmanial effect of NTZ when administered as NTZ-TEG.</p>
Microdata on vector abundance and IRS quality assurance (Estimating the impact of indoor residual spraying on sandfly abundance and incidence of visceral leishmaniasis in India from 2016 to 2022: an interrupted time-series analysis and modelling study)
<p>This repository contains the microdata on vector abundance and quality assurance of indoor residual spraying (IRS) that was used to estimate the impact of IRS on sandfly abundance and incidence of visceral leishmaniasis (VL) in India, as described in the paper "Estimating the impact of indoor residual spraying on sandfly abundance and incidence of visceral leishmaniasis in India from 2016 to 2022: an interrupted time-series analysis and modelling study" by Coffeng et al (<a href="https://doi.org/10.1016/S1473-3099(24)00420-1">https://doi.org/10.1016/S1473-3099(24)00420-1</a>). These data were collected as part of a BMGF-funded project led by dr. Michael Coleman at the Liverpool School for Tropical Medicine, as described in an earlier paper by Deb et al (<a href="https://doi.org/10.1371/journal.pntd.0009101">https://doi.org/10.1371/journal.pntd.0009101</a>).</p> <p>This repository does not include microdata on VL cases as these are owned by India's National Center for Vector Borne Disease Control (NCVBDC, <a href="https://ncvbdc.mohfw.gov.in/" target="_blank" rel="nofollow noreferrer noopener">https://ncvbdc.mohfw.gov.in/</a>).</p>
Figure 5 in Leishmaniasis and phlebotomine sand flies in Oman Sultanate
Figure 5. Ulcero-scabby lesion of case LCO 2.
Figure 4 in Leishmaniasis and phlebotomine sand flies in Oman Sultanate
Figure 4. Pharynx of Ph. saevus (A), Ph. sergenti (B) and cibarium of Se. baghdadis (C).
Fig. 1 in Characterization of Leishmania spp. causing cutaneous leishmaniasis in Manaus, Amazonas, Brazil
Fig. 1 Locations of case occurrence in Manaus and its metropolitan regions
Table 2 in Leishmaniasis and phlebotomine sand flies in Oman Sultanate
<p><b>Table 2.</b> Captures made using sticky traps in locations mentioned in Figures 1 and 2. ³ = males, ♀ = females, ³ + ♀ = males and females, s/m 2 = density of sandflies (per m 2 of sticky paper).</p><table><tbody><tr><th>Location</th><th></th><th>Sharqiyah</th><th></th><th></th><th></th><th>Dh2</th><th></th><th></th><th></th><th>Dh3</th><th></th><th></th><th></th><th>Dh5</th><th></th><th></th><th>Dh6</th><th></th><th>Total Dhofar</th></tr></tbody><tbody><tr><th>Species</th><td>³</td><td>♀</td><td>³ + ♀</td><td>s/m2</td><td>³</td><td>♀</td><td>³ + ♀ s/m2</td><td>³</td><td>♀</td><td>³ + ♀</td><td>s/m2</td><td>³</td><td>♀</td><td>³ + ♀</td><td>s/m2</td><td>³</td><td>♀</td><td>³ + ♀</td><td>s/m2</td><td>³</td><td>♀</td><td>³ + ♀ s/m2</td></tr><tr><th><i>Phlebotomus</i></th><td>35</td><td>14</td><td>49</td><td>1.16</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th><i>papatasi</i></th></tr><tr><th><i>Phlebotomus</i></th><td>2</td><td>2</td><td>4</td><td>0.09</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>45</td><td>4</td><td>49</td><td>0.84</td><td>45</td><td>4</td><td>49</td><td>2.13</td></tr><tr><th><i>bergeroti</i></th><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th><i>Phlebotomus</i></th><td></td><td>2</td><td>2</td><td>0.05</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th><i>duboscqi</i></th></tr><tr><th><i>Phlebotomus</i></th><td>3</td><td></td><td>3</td><td>0.07</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>31</td><td>4</td><td>35</td><td>0.60</td><td>31</td><td>4</td><td>35</td><td>1.52</td></tr><tr><th><i>alexandri</i></th><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th><i>Phlebotomus</i></th><td></td><td></td><td></td><td></td><td>4</td><td></td><td>4</td><td>1.43</td><td></td><td>4</td><td>4</td><td>0.51</td><td>2</td><td></td><td>2</td><td>0.42</td><td>1</td><td>1</td><td>2</td><td>0.03</td><td>7</td><td>5</td><td>12</td><td>0.52</td></tr><tr><th><i>saevus</i></th></tr><tr><th><i>Phlebotomus</i></th><td>8</td><td></td><td>8</td><td>0.19</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>7</td><td>3</td><td>10</td><td>0.17</td><td>7</td><td>3</td><td>10</td><td>0.43</td></tr><tr><th><i>sergenti</i></th><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th><i>Grassomyia</i></th><td></td><td>2</td><td>2</td><td>0.05</td><td></td><td>1</td><td>1</td><td>0.36</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>1</td><td>1</td><td>0.04</td></tr><tr><th><i>dreyfussi</i></th></tr><tr><th><i>Sergentomyia</i></th><td>4</td><td>4</td><td>8</td><td>0.19</td><td>27</td><td>30</td><td>57</td><td>20.36</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>22</td><td>50</td><td>72</td><td>1.23</td><td>49</td><td>80</td><td>129</td><td>5.60</td></tr><tr><th><i>fallax</i></th><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th><i>Sergentomyia</i></th><td>29</td><td>9</td><td>38</td><td>0.90</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>5</td><td>2</td><td>7</td><td>0.12</td><td>5</td><td>2</td><td>7</td><td>0.30</td></tr><tr><th><i>cincta</i></th><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th><i>Sergentomyia</i></th><td>67</td><td>39</td><td>106</td><td>2.51</td><td>1</td><td>8</td><td>9</td><td>3.21</td><td></td><td>3</td><td>3</td><td>0.38</td><td></td><td></td><td></td><td></td><td>8</td><td>6</td><td>14</td><td>0.24</td><td>9</td><td>17</td><td>26</td><td>1.13</td></tr><tr><th><i>christophersi</i></th></tr><tr><th><i>Sergentomyia</i></th><td>5</td><td>4</td><td>9</td><td>0.21</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th><i>clydei</i></th><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th><i>Sergentomyia</i></th><td>50</td><td>21</td><td>71</td><td>1.68</td><td>2</td><td>8</td><td>10</td><td>3.57</td><td>1</td><td>6</td><td>7</td><td>0.89</td><td>1</td><td></td><td>1</td><td>0.21</td><td>52</td><td>26</td><td>78</td><td>1.34</td><td>56</td><td>40</td><td>96</td><td>4.17</td></tr><tr><th><i>tiberiadis</i></th></tr><tr><th><i>Sergentomyia</i></th></tr><tr><th><i>africana</i></th></tr><tr><th><i>Sergentomyia</i></th><td>13</td><td>12</td><td>25</td><td>0.59</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th><i>baghdadis</i></th></tr><tr><th><i>Sergentomyia</i></th><td>1</td><td>2</td><td>3</td><td>0.07</td><td>1</td><td></td><td>1</td><td>0.36</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>1</td><td></td><td>1</td><td>0.04</td></tr><tr><th><i>(Sintonius) sp.</i></th><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th>Undetermined</th><td>3</td><td></td><td>3</td><td>0.07</td><td>1</td><td></td><td>1</td><td>0.36</td><td></td><td>1</td><td>1</td><td>0.13</td><td></td><td></td><td></td><td></td><td>4</td><td>4</td><td>8</td><td>0.14</td><td>5</td><td>5</td><td>10</td><td>0.43</td></tr><tr><th>Total</th><td>220</td><td>111</td><td>331</td><td>7.85</td><td>36</td><td>47</td><td>83</td><td>29.64</td><td>1</td><td>14</td><td>15</td><td>1.91</td><td>3</td><td>0</td><td>3</td><td>0.63</td><td>175</td><td>100 275</td><td>4.71</td><td>215 161</td><td>376 16.32</td></tr></tbody></table>
Table 3 in Leishmaniasis and phlebotomine sand flies in Oman Sultanate
<p><b>Table 3.</b> Captures made using CDC miniature light traps in locations mentioned in Figures 1 and 2. ³ = males, ♀ = females, ³ + ♀ = males and females, s/n/t = number of sandflies per night per trap.</p><table><tbody><tr><th>Location</th><th></th><th>Sharqiyah</th><th></th><th></th><th></th><th>Dh3</th><th></th><th></th><th></th><th>Dh6</th><th></th><th></th><th>Total Dhofar</th><th></th></tr></tbody><tbody><tr><th>Species</th><td>³</td><td>♀</td><td>³ + ♀</td><td>s/n/t</td><td>³</td><td>♀</td><td>³ + ♀</td><td>s/n/t</td><td>³</td><td>♀</td><td>³ + ♀</td><td>s/n/t</td><td>³</td><td>♀</td><td>³ + ♀</td><td>s/n/t</td></tr><tr><th><i>Phlebotomus papatasi</i></th><td>3</td><td>13</td><td>16</td><td>0.94</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th><i>Phlebotomus bergeroti</i></th><td>1</td><td>4</td><td>5</td><td>0.29</td><td>1</td><td></td><td>1</td><td>0.14</td><td>57</td><td>27</td><td>84</td><td>16.8</td><td>58</td><td>27</td><td>85</td><td>7.08</td></tr><tr><th><i>Phlebotomus duboscqi</i></th></tr><tr><th><i>Phlebotomus alexandri</i></th><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>15</td><td>16</td><td>31</td><td>6.2</td><td>15</td><td>16</td><td>31</td><td>2.58</td></tr><tr><th><i>Phlebotomus saevus</i></th><td></td><td></td><td></td><td></td><td>34</td><td>18</td><td>52</td><td>7.43</td><td>1</td><td>2</td><td>3</td><td>0.6</td><td>35</td><td>20</td><td>55</td><td>4.58</td></tr><tr><th><i>Phlebotomus sergenti</i></th></tr><tr><th><i>Grassomyia dreyfussi</i></th></tr><tr><th><i>Sergentomyia fallax</i></th><td></td><td></td><td></td><td></td><td>4</td><td>2</td><td>6</td><td>0.86</td><td>9</td><td>22</td><td>31</td><td>6.2</td><td>13</td><td>24</td><td>37</td><td>3.08</td></tr><tr><th><i>Sergentomyia cincta</i></th><td></td><td>2</td><td>2</td><td>0.12</td><td>1</td><td></td><td>1</td><td>0.14</td><td></td><td></td><td></td><td></td><td>1</td><td></td><td>1</td><td>0.08</td></tr><tr><th><i>Sergentomyia christophersi</i></th><td>4</td><td>5</td><td>9</td><td>0.53</td><td>4</td><td>2</td><td>6</td><td>0.86</td><td>5</td><td>6</td><td>11</td><td>2.2</td><td>9</td><td>8</td><td>17</td><td>1.42</td></tr><tr><th><i>Sergentomyia clydei</i></th><td>3</td><td>1</td><td>4</td><td>0.24</td><td>1</td><td></td><td>1</td><td>0.14</td><td></td><td></td><td></td><td></td><td>1</td><td></td><td>1</td><td>0.08</td></tr><tr><th><i>Sergentomyia tiberiadis</i></th><td></td><td>1</td><td>1</td><td>0.06</td><td>6</td><td>2</td><td>8</td><td>1.14</td><td>3</td><td>3</td><td>6</td><td>1.2</td><td>9</td><td>5</td><td>14</td><td>1.17</td></tr><tr><th><i>Sergentomyia africana</i></th><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td>2</td><td>2</td><td>0.4</td><td></td><td>2</td><td>2</td><td>0.17</td></tr><tr><th><i>Sergentomyia baghdadis</i></th><td>25</td><td>53</td><td>78</td><td>4.59</td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td><td></td></tr><tr><th><i>Sergentomyia (Sintonius) sp.</i></th></tr><tr><th>Undetermined</th><td></td><td></td><td></td><td></td><td>1</td><td></td><td>1</td><td>0.14</td><td></td><td>1</td><td>1</td><td>0.2</td><td>1</td><td>1</td><td>2</td><td>0.17</td></tr><tr><th>Total</th><td>36</td><td>79</td><td>115</td><td>6.76</td><td>52</td><td>24</td><td>76</td><td>10.9</td><td>90</td><td>79</td><td>169</td><td>33.8</td><td>142</td><td>103</td><td>245</td><td>20</td></tr></tbody></table>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.