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57 results for “leptomeningeal metastasis”
Leptomeningeal metastasis from Adrenocortical carcinoma: a case report
<p>Adrenocortical carcinoma (ACC) is an uncommon endocrine malignancy with limited treatment options. While overall 5-year survival rate in patients with ACC is 35%, the disease is often rapidly progressive with long-term survival in only 5% of patients. Although tumor stage, grade and excess hormonal activity predict unfavorable prognosis, additional biomarkers are needed to identify patients with aggressive disease.</p> <p>A 23-year-old woman presented with rapidly progressing signs and symptoms of Cushing's syndrome, with associated abdominal pain and fullness. Evaluation revealed a large left adrenal mass which had developed over 8 months. En bloc surgical resection was performed by an endocrine surgeon, and pathology revealed adrenocortical carcinoma with Ki67 of 60%. Despite adjuvant treatment with mitotane and etoposide-doxorubicin-carboplatin chemotherapy, the patient had rapid disease progression with metastatic spread to liver, lung, bone, brain and leptomeningies and she died eleven months after the initial diagnosis. Subsequent analysis of patient's tumor revealed mutations in TP53 and MEN1. RNA sequencing was compared against the The Cancer Genome Atlas data set and clustered with the high steroid, proliferative subtype, associated with the worst prognosis. The tumor also demonstrated a low BUB1B/PINK1 ratio as well as G0S2 hypermethylation, both predictive of very aggressive ACC.</p> <p>This case represents a subset of ACC characterized by rapid and fatal progression. Clinically available predictors as well as recently reported molecular signatures and biomarkers correlated with this tumor's aggressiveness, suggesting that development and validation of combinations of biomarkers may be useful in guiding personalized approaches to patients with ACC.</p>
Proton Craniospinal Radiation Therapy vs. Partial Photon Radiation Therapy for Leptomeningeal Metastasis From Solid Tumors
ClinicalTrials.gov study NCT04343573. IPD Sharing: YES. Countries: 1. Publications: 2.
Leptomeningeal metastasis from Adrenocortical carcinoma: a case report
Open the record for dataset details and reuse information.
Intra-pemetrexed Plus Third-generation Small Molecule TKI Drugs (e.g. 'Osimertinib') Versus Third-generation Small Molecule TKI Drugs Alone for Leptomeningeal Metastasis From Epidermal Growth Factor R
ClinicalTrials.gov study NCT06304441. IPD Sharing: YES. Countries: 1. Publications: 3.
Concurrent Intrathecal-pemetrexed and Involved-field Radiotherapy for Leptomeningeal Metastasis From Solid Tumors
ClinicalTrials.gov study NCT03507244. IPD Sharing: Not stated. Countries: 1. Publications: 11.
Intrathecal Pemetrexed for Leptomeningeal Metastasis
ClinicalTrials.gov study NCT05289908. IPD Sharing: YES. Countries: 1. Publications: 3.
Immune Checkpoint Inhibitor Combined With Pemetrexed Intrathecal Injection for Leptomeningeal Metastasis From Solid Tumors
ClinicalTrials.gov study NCT06462222. IPD Sharing: YES. Countries: 1. Publications: 2.
Standardized Clinical Assessment of Patients With Leptomeningeal Metastasis
ClinicalTrials.gov study NCT06417710. IPD Sharing: Not stated. Countries: 3. Publications: 1.
A Multi-center Prospective Observational Biomarker Study on EGFRm+ Non-small Cell Lung Cancer Patients With Leptomeningeal Metastasis
ClinicalTrials.gov study NCT02803619. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Bevacizumab With Etoposide and Cisplatin in Breast Cancer Patients With Brain and/or Leptomeningeal Metastasis
ClinicalTrials.gov study NCT01281696. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Osimertinib With Bevacizumab for Leptomeningeal Metastasis From EGFR-mutation Non-Small Cell Lung Cancer
ClinicalTrials.gov study NCT04425681. IPD Sharing: NO. Countries: 1. Publications: 14.
Almonertinib With Bevacizumab for EGFR-Mutant NSCLC Patients With Leptomeningeal Metastasis
ClinicalTrials.gov study NCT04944069. IPD Sharing: NO. Countries: 1. Publications: 19.
Intrathecal Combination of Programmed Death-1 (PD-1)/Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA-4) Bispecific Antibody and Pemetrexed for Leptomeningeal Metastasis
ClinicalTrials.gov study NCT06762080. IPD Sharing: NO. Countries: 1. Publications: 2.
Intrathecal Pemetrexed for Leptomeningeal Metastasis From Lung Adenocarcinoma That Progressed After Osimertinib.
ClinicalTrials.gov study NCT06296745. IPD Sharing: YES. Countries: 1. Publications: 4.
Intra-pemetrexed Alone or Combined With Concurrent Radiotherapy for Leptomeningeal Metastasis
ClinicalTrials.gov study NCT05305885. IPD Sharing: YES. Countries: 1. Publications: 3.
Microfluidic Device to Diagnose Leptomeningeal Metastasis in Breast Cancer
ClinicalTrials.gov study NCT02948751. IPD Sharing: YES. Countries: 1. Publications: 0.
Study of Craniospinal Irradiation With Linac Based Volumetric Modulated Arc Therapy (VMAT) for Patients With Leptomeningeal Metastasis
ClinicalTrials.gov study NCT06984523. IPD Sharing: YES. Countries: 1. Publications: 0.
Osimertinib With or Without Bevacizumab for EGFR- Mutant Non-small Cell Lung Cancer With Leptomeningeal Metastasis
ClinicalTrials.gov study NCT04148898. IPD Sharing: NO. Countries: 0. Publications: 10.
A Study of Deferoxamine (DFO) in People With Leptomeningeal Metastasis
ClinicalTrials.gov study NCT05184816. IPD Sharing: YES. Countries: 1. Publications: 0.
Phenotypic states of leptomeningeal metastasis
GEO Series GSE137020. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.