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22 results for “levamisole”
Ascaris intestine calcium fluorescence dataset showing synergism of levamisole and Cry5B
<p><span>A novel class of biocidal compounds are the Crystal 3D (Cry) and Cytolytic (Cyt) proteins produced by <em>Bacillus thuringiensis </em>(Bt). Some Bt Cry proteins have a selective nematocidal activity, with Cry5B being the most studied. Cry5B kills nematode parasites by binding selectively to membrane glycosphingolipids, then forming pores in the cell membranes of the intestine leading to damage. Cry5B selectively targets multiple species of nematodes from different clades and has no effect against mammalian hosts. Levamisole is a cholinomimetic anthelmintic that acts by selectively opening L-subtype nicotinic acetylcholine receptor ion-channels (L-AChRs) that have been found on muscles of nematodes. A synergistic nematocidal interaction between levamisole and Cry5B has been described previously on whole worms, but the location, mechanism and time-course of this synergism is not known. In this study we follow the timeline of the effects of levamisole and Cry5B on the Ca<sup>2+</sup> levels of enterocyte cells of the intestine of <em>Ascaris suum</em> using fluorescence imaging. </span><span> The peak <span>Ca<sup>2+</sup> responses</span> to <span>levamisole were observed after approximately 10 minutes and the peak responses to activated Cry5B were seen after approximately 80 minutes. </span>When levamisole and Cry5B were applied simultaneously, we observed that the responses to Cry5B were bigger and occurred sooner than when it was applied by itself. It is proposed that there is an irreversible cytoplasmic Ca<sup>2+</sup> overload that leads to cell-death in the enterocyte that is induced by levamisole opening Ca<sup>2+</sup> permeable L-subtype nAChRs and the development of Ca<sup>2+</sup> permeable Cry5B toxin pores in enterocyte plasma membranes. The effects of levamisole potentiate and speed the actions of Cry5B. </span></p>
Magnetic particles (Fe3O4) magnify ion transfer processes at the electrified liquid-liquid interface. Case study: Levamisole detection.
<p>Data set for the publication Magnetic particles (Fe3O4) magnify ion transfer processes at the electrified liquid-liquid interface. Case study: Levamisole detection. </p>
Ascaris intestine calcium fluorescence dataset showing synergism of levamisole and Cry5B
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Effect of Levamisole Supplementation on Tetanus Vaccination Response Rates in Hemodialysis Patients
ClinicalTrials.gov study NCT00705692. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluation of Efficacy of Levamisole and Formoterol+Budesonide in Treatment of COVID-19
ClinicalTrials.gov study NCT04331470. IPD Sharing: YES. Countries: 1. Publications: 18.
Efficiency of Levamisole for Maintaining Remission After the First Flare of Steroid Sensitive Nephrotic Syndrome in Children
ClinicalTrials.gov study NCT02818738. IPD Sharing: NO. Countries: 1. Publications: 1.
Safety and Efficacy of Levamisole Combined With Cyclosporine A in Patients With Classic Paroxysmal Nocturnal Hemoglobinuria
ClinicalTrials.gov study NCT01642979. IPD Sharing: Not stated. Countries: 1. Publications: 1.
A 3- to 5-day Clinical Trial of Levamisole in Loiasis Infected Subjects
ClinicalTrials.gov study NCT06252961. IPD Sharing: NO. Countries: 1. Publications: 1.
Comparison of Efficacy of Azithromycin and Levamisole Versus of Azithromycin in in the Treatment of Acne
ClinicalTrials.gov study NCT01348321. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Efficacy Albendazole and Levamisole Against STH on Unguja
ClinicalTrials.gov study NCT00659997. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Safety and Efficacy of Levamisole Combined With Cyclosporine A in Patients With Subclinical Paroxysmal Nocturnal Hemoglobinuria and PNH in the Setting of Another Bone Marrow Failure Syndromes(PNH-2013
ClinicalTrials.gov study NCT01760096. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Clinical Trial Evaluating the Safety and Efficacy of Levamisole in Loa Loa Microfilaremic Patients
ClinicalTrials.gov study NCT04049630. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The effects of levamisole in Greater Wax Moth larvae hemolymph
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Fluorouracil and Leucovorin and/or Levamisole After Surgery In Treating Patients With Dukes' B Or Dukes' C Colon Cancer
ClinicalTrials.gov study NCT00425152. IPD Sharing: Not stated. Countries: 0. Publications: 8.
Effect of levamisole on conditionally immortalized human podocytes (cihPod)
GEO Series GSE229250. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Levamisole and Isoprinosine in Immune-prophylaxis of Egyptian Healthcare Workers Facing COVID-19
ClinicalTrials.gov study NCT04360122. IPD Sharing: NO. Countries: 1. Publications: 0.
Efficacy and Safety of Levamisole Combined With Standard Prednisolone in Warm Antibody Autoimmune Hemolytic Anemia.
ClinicalTrials.gov study NCT01579110. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Clinical Study on the Efficacy of Acetazolamide Combined With Levamisole in the Treatment of HCC
ClinicalTrials.gov study NCT04611373. IPD Sharing: NO. Countries: 1. Publications: 0.
Clinical Study of Non Severe Aplastic Anemia Treated With Cyclosporine, Androgen and Levamisole
ClinicalTrials.gov study NCT03218657. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Levamisole and Isoprinosine in the Treatment of COVID19: A Proposed Therapeutic Trial
ClinicalTrials.gov study NCT04383717. IPD Sharing: NO. Countries: 0. Publications: 0.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.