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3 results for “leverage points”
Data and R-scripts for "Land-use trajectories for sustainable land system transformations: identifying leverage points in a global biodiversity hotspot" (V2)
<p>Sustainable land system transformations are necessary to avert biodiversity and climate collapse. However, it remains unclear where entry points for transformations exist in complex land systems. Here, we conceptualize land systems along land-use trajectories, which allows us to identify and evaluate leverage points; i.e., entry points on the trajectory where targeted interventions have particular leverage to influence land-use decisions. We apply this framework in the biodiversity hotspot Madagascar. In the Northeast, smallholder agriculture results in a land-use trajectory originating in old-growth forests, spanning forest fragments, and reaching shifting hill rice cultivation and vanilla agroforests. Integrating interdisciplinary empirical data on seven taxa, five ecosystem services, and three measures of agricultural productivity, we assess trade-offs and co-benefits of land-use decisions at three leverage points along the trajectory. These trade-offs and co-benefits differ between leverage points: two leverage points are situated at the conversion of old-growth forests and forest fragments to shifting cultivation and agroforestry, resulting in considerable trade-offs, especially between endemic biodiversity and agricultural productivity. Here, interventions enabling smallholders to conserve forests are necessary. This is urgent since ongoing forest loss threatens to eliminate these leverage points due to path-dependency. The third leverage point allows for the restoration of land under shifting cultivation through vanilla agroforests and offers co-benefits between restoration goals and agricultural productivity. The co-occurring leverage points highlight that conservation and restoration are simultaneously necessary. Methodologically, the framework shows how leverage points can be identified, evaluated, and harnessed for land system transformations under the consideration of path-dependency along trajectories.</p>
Phosphoglycerate kinase is a central leverage point in Parkinson's Disease driven neuronal metabolic deficits
<p><span>Although certain drivers of familial Parkinson’s Disease (PD) compromise mitochondrial integrity, whether metabolic deficits underly other idiopathic or genetic origins of PD is unclear. Here, we demonstrate that PGK1, a gene in the PARK12 susceptibility locus, <span> </span>is rate limiting in neuronal glycolysis and that modestly increasing PGK1 expression significantly boosts <span> </span>neuronal ATP production kinetics that is sufficient to suppress PARK20-driven synaptic dysfunction. We found that his activity enhancement depends on the molecular chaperone PARK7/DJ-1, whose loss of function significantly disrupts axonal bioenergetics. <em>In-vivo, </em>viral expression of PGK1 confers protection of striatal DA axons against metabolic lesions. These data support the notion that bioenergetic deficits may underpin PD associated pathologies and point to improving neuronal ATP production kinetics as a promising path forward in PD therapeutics.</span></p>
Leverage Points in Modality shifts: Comparing Language-only and Multimodal Word Representations
<p>Dataset for the blind submission of Leverage Points in Modality shifts: Comparing Language-only and Multimodal Word Representations paper</p>
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.