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71 results for “linoleic acid”
Supplementary data to publication "Abomasal infusion of essential fatty acids and conjugated linoleic acid during late pregnancy and early lactation affects immunohematological and oxidative stress markers in dairy cows"
<p>Supplementary data to publication "Abomasal infusion of essential fatty acids and conjugated linoleic acid during late pregnancy and early lactation affects immunohematological and oxidative stress markers in dairy cows" in Journal of Dairy Science; DOI: <a href="https://doi.org/10.3168/jds.2022-22514">https://doi.org/10.3168/jds.2022-22514</a></p>
CELLOIDS: pH-responsive DOPC Giant Unilamellar Vesicles with and without Linoleic Acid
<p>As part of the CELLOIDS project, one of our main research focuses is exploring the feasibility of making the microrobot's membrane responsive to a pH gradient. Specifically, we investigated the incorporation of linoleic acid into Giant unilamellar vesicles composed of DOPC (1,2-dioleoyl-sn-glycero-3-phosphocholine).</p> <p>The provided dataset compiles the diameters of liposomes prepared with DOPC (3.18 mM), DOPC:LA (linoleic acid) at a molar ratio of 100:1, and DOPC:LA at a molar ratio of 50:1. These liposomes were placed in buffers at both pH 6 and pH 7, simulating conditions similar to the tumor microenvironment. Our objective was to assess the stability of these liposomes under these conditions.</p> <p>In detail, we carefully prepared liposomes with varying molar ratios of DOPC and linoleic acid to determine the optimal amount of linoleic acid that induces membrane deformation while maintaining the structural integrity of the liposomes in acidic solutions. Subsequently, we subjected the liposomes to testing at the specified concentrations and compared their behavior under two different pH values. Finally, we observed the samples using a phase-contrast microscope immediately after the addition of the solutions and after a one-hour incubation period.</p>
The effects of dietary linoleic acid and hydrophilic antioxidants on basal, peak, and sustained metabolism in flight trained European Starlings
<p>Dietary micronutrients have the ability to strongly influence animal physiology and ecology. For songbirds, dietary polyunsaturated fatty acids (PUFAs) and antioxidants are hypothesized to be particularly important micronutrients because of their influence on an individual's capacity for aerobic metabolism and recovery from extended bouts of exercise. However, the influence of specific fatty acids and hydrophilic antioxidants on whole-animal performance remain largely untested. We used diet manipulations to directly test the effects of dietary PUFA, specifically linoleic acid (18:2n6), and anthocyanins, a hydrophilic antioxidant, on basal metabolic rate (BMR), peak metabolic rate (PMR), and rates of fat catabolism, lean catabolism, and energy expenditure during sustained flight in a wind tunnel in European starlings (Sturnus vulgaris). BMR, PMR, energy expenditure, and fat metabolism decreased and lean catabolism increased over the course of the experiment in birds fed a high (32%) 18:2n6 diet, while birds fed a low (13%) 18:2n6 diet exhibited the reverse pattern. Additionally, energy expenditure, fat catabolism, and flight duration were all subject to diet-specific effects of whole-body fat content. Dietary antioxidants and diet-related differences in tissue fatty acid composition were not directly related to any measure of whole-animal performance. Together, these results suggest that the effect of dietary 18:2n6 on performance was most likely the result of the signaling properties of 18:2n6. This implies that dietary PUFA influence the energetic capabilities of songbirds, and could strongly influence songbird ecology, given their availability in terrestrial systems.</p>
Data from: Oxidation of linoleic and palmitic acid in pre-hibernating and hibernating common noctule bats revealed by 13C breath testing
Mammals fuel hibernation by oxidizing saturated and unsaturated fatty acids from triacylglycerols in adipocytes, yet the relative importance of these two categories as an oxidative fuel may change during hibernation. We studied the selective use of fatty acids as an oxidative fuel in noctule bats (<i>Nyctalus noctula</i>). Pre-hibernating noctule bats that were fed 13C-enriched linoleic acid (LA) showed 12 times higher tracer oxidation rates compared to conspecifics fed 13C-enriched palmitic acid (PA). After this experiment, we supplemented the diet of bats with the same fatty acids on 5 subsequent days to enrich their fat depots with the respective tracer. We then compared the excess 13C enrichment (APE) in breath of bats for torpor and arousal events during early and late hibernation. We observed higher APE values in breath of bats fed 13C-enriched LA than in bats fed 13C-enriched PA for both states, torpor and arousal, and also for both periods. Thus, hibernating bats oxidized selectively endogenous LA instead of PA, most likely because of faster transportation rates of PUFA compared with SFA. We did not observe changes in APE values in the breath of torpid animals between early and late hibernation. Skin temperature of torpid animals increased by 0.7oC between early and late hibernation in bats fed PA, whereas it decreased by -0.8oC in bats fed LA, highlighting that endogenous LA may fulfil two functions when available in excess: serving as an oxidative fuel and supporting cell membrane functionality.
Novel gene regulatory networks identified in response to nitro-conjugated linoleic acid in human endothelial cells
<p>A distinct transcriptome regulated by NO<sub>2-</sub>CLA was revealed in primary human coronary artery endothelial cells (HCAECs) through RNA sequencing. </p>
Targeted lipidomics yields changes in both arachidonic acid and linoleic acid pathways observed in C57BL/6J mice compared to KitW-sh mice after nitrogen mustard exposure
<p>Sulfur mustard (SM) has been widely used as a chemical warfare agent including most recently in Syria. Mice exposed to SM exhibit an increase in pro-inflammatory cytokines followed by immune cell infiltration in the lung, however, the mechanisms leading to these inflammatory responses has not been completely elucidated. Mast cells are one of the first responding innate immune cells found at the mucosal surfaces of the lung and have been reported to be activated by SM in the skin. Therefore, we hypothesized that nitrogen mustard (NM: a surrogate for SM) exposure promotes activation of mast cells causing chronic respiratory inflammation. To assess the role of mast cells in NM-mediated pulmonary toxicity, we compared the effects of NM exposure between C57BL/6 and B6.Cg-KitW-sh/HNihrJaeBsmJ (Kit<sup><em>W-s</em></sup><sup>h</sup>; mast cell deficient) mice. Lung injury was observed in C57BL/6J mice following NM exposure (0.125 mg/kg) at 72 h, which was significantly abrogated in Kit<sup><em>W-s</em></sup><sup>h</sup> mice. Although both strains exhibited damage from NM, C57BL/6J mice had higher inflammatory cell infiltration and more elevated prostaglandin D<sub>2</sub> (PGD<sub>2</sub>) present in bronchoalveolar lavage fluid compared with Kit<sup><em>W-s</em></sup><sup>h</sup> mice. Additionally, we utilized murine bone marrow-derived mast cells to assess NM-inducedearly and late activation. Although NM exposure did not result in mast cell degranulation, we observed an upregulation in PGD<sub>2</sub> and IL-6 levels following exposure to NM. Results suggest that mast cells play a prominent role in lung injury induced by NM and may contribute to the acute and potentially long-term lung injury observed caused by SM.</p>
The Effects of Supplementation of Conjugated Linoleic Acid on Body Fat Reduction
ClinicalTrials.gov study NCT03915808. IPD Sharing: NO. Countries: 1. Publications: 3.
Metabolic Effects of Linoleic Acid-Rich Oil Compared to a Blend Oil in Adults With Insulin Resistance
ClinicalTrials.gov study NCT07287514. IPD Sharing: NO. Countries: 1. Publications: 5.
Conjugated Linoleic Acid in Obese Women
ClinicalTrials.gov study NCT02529046. IPD Sharing: Not stated. Countries: 1. Publications: 41.
Conjugated Linoleic Acid and Atherosclerosis
ClinicalTrials.gov study NCT00706745. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Dietary Linoleic Acid for Secondary Prevention of Coronary Heart Disease and Death in the Sydney Heart Study: an RCT
ClinicalTrials.gov study NCT01621087. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Conjugated Linoleic Acid Supplementation Study
ClinicalTrials.gov study NCT01234636. IPD Sharing: Not stated. Countries: 1. Publications: 15.
Metformin vs Conjugated Linoleic Acid and an Intervention Program With Healthy Habits in Obese Children
ClinicalTrials.gov study NCT02063802. IPD Sharing: Not stated. Countries: 1. Publications: 1.
NETwork of Linoleic Acid Supplementation in Cystic Fibrosis
ClinicalTrials.gov study NCT04531410. IPD Sharing: NO. Countries: 3. Publications: 4.
Effect of Conjugated Linoleic Acid Intake on Liver and Kidney Function
ClinicalTrials.gov study NCT00449462. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Supplementation With Conjugated Linoleic Acid (CLA) as Complementary Therapy in the Management of Type 2 Diabetes Mellitus (Women's Diabetes Study)
ClinicalTrials.gov study NCT01121471. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Soy Peptide, Conjugated Linoleic Acid, Overweight or Obese, Body Composition
ClinicalTrials.gov study NCT04728399. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Impact of an 8-week Linoleic Acid Intake in Soy Oil on Lp-PLA2 Activity in Healthy Adults
ClinicalTrials.gov study NCT02753907. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Fatty Acid Taste Thresholds: Caproic, Lauric, Oleic, Linoleic, Linolenic
ClinicalTrials.gov study NCT01996566. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Conjugated Linoleic Acid (1:1 Isomer Mixture) Intake in Overweight People
ClinicalTrials.gov study NCT01503047. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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Allen Brain Atlas
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DANDI Archive for NWB datasets
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