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498 results for “liver fibrosis”
Dihydrosphingolipids are associated with steatosis and increased fibrosis damage in human and animal models of non-alcoholic fatty liver disease
<p>Data sets used for the article entitled: "Accumulation of dihydrosphingolipids and neutral lipids is related to steatosis and fibrosis damage in human and animal models of non-alcoholic fatty liver disease"</p> <p>- Patient data: DATA Patients JLR.xlsx</p> <p>- Mouse data: DATA Mice.xlsx</p>
Knockout of liver fluke granulin, Ov-grn-1, impedes malignant transformation during chronic infection with Opisthorchis viverrini: BrdU staining and fibrosis
<p>Knockout of liver fluke granulin, Ov-grn-1, impedes malignant transformation during chronic infection with Opisthorchis viverrini:</p> <p>1. BrdU stained images for the detection of proliferation with manual counting of brown stained cell proportion. Each group in a seperate file BRDUxxx</p> <p>2. Fibrosis local images stained with Sirius red with automated analysis with imageJ. Grouped into one zip file</p> <p>3. Global analysis of liver fibrosis pathogenesis (Ishak scores) performed by 2 blinded pathologists. Grouped into one zip file</p> <p>Methods in associated publication. Briefly 3 groups of 15 hamsters were infected with 100 NEJ flukes that had been gene edited with CRISPR/Cas9 plasmids targeting either Ov-grn-1, Ov-tsp-2, or a scrambled sequence as the control group. Images in these files are the micrographs from these three groups of hamsters. Numbered 1-15 representing the hamster and left/middle/right representing the liver lobe the section was taken from.</p> <p> </p> <p>Knockout of liver fluke granulin, Ov-grn-1, impedes malignant transformation during chronic infection with Opisthorchis viverrini</p> <p>ABSTRACT: Infection with the food-borne liver fluke <em>Opisthorchis viverrini</em> is the principal risk factor for cholangiocarcinoma (CCA) in the Mekong Basin countries of Thailand, Lao PDR, Vietnam, Myanmar and Cambodia. Using a novel model of CCA, involving infection with gene-edited liver flukes in the hamster during concurrent exposure to dietary nitrosamine, we explored the role of the fluke granulin-like growth factor <em>Ov</em>-GRN-1 in malignancy. We derived RNA-guided gene knockout flukes (<em>ΔOv-grn-1)</em> using CRISPR/Cas9/gRNA materials delivered by electroporation. Genome sequencing confirmed programmed Cas9-catalyzed mutations of the targeted genes, which was accompanied by rapid depletion of transcripts and the proteins they encode. Gene-edited parasites colonized the biliary tract of hamsters and developed into adult flukes. However, less hepatobiliary tract disease manifested during chronic infection with <em>ΔOv-grn-1</em> worms in comparison to hamsters infected with control gene-edited and mock-edited parasites. Specifically, immuno- and colorimetric-histochemical analysis of livers revealed markedly less periductal fibrosis surrounding the flukes and less fibrosis globally within the hepatobiliary tract during infection with <em>ΔOv-grn-1</em> genotype worms, minimal biliary epithelial cell proliferation, and significantly fewer mutations of <em>TP53</em> in biliary epithelial cells. Moreover, fewer hamsters developed high-grade CCA compared to controls. The clinically relevant, pathophysiological phenotype of the hepatobiliary tract confirmed a role for this secreted growth factor in malignancy and morbidity during opisthorchiasis.</p>
Study of Safety, Tolerability, and Efficacy of a Combination Treatment of LJN452 and CVC in Adult Patients With NASH and Liver Fibrosis
ClinicalTrials.gov study NCT03517540. IPD Sharing: UNDECIDED. Countries: 17. Publications: 2.
Rawdata of a bibliometric analysis of liver fibrosis magnetic resonance imaging research from 1998 to 2017
<p>The details of all literature downloaded from WoSCC as plain-text files including the full records.</p>
Study of Simtuzumab in HIV and/or Hepatitis C- Infected Adults With Liver Fibrosis
ClinicalTrials.gov study NCT01707472. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Detection of Liver Fibrosis With Magnetic Resonance Imaging (MRI)
ClinicalTrials.gov study NCT01600105. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Simtuzumab (GS-6624) in the Prevention of Progression of Liver Fibrosis in Adults With Primary Sclerosing Cholangitis (PSC)
ClinicalTrials.gov study NCT01672853. IPD Sharing: Not stated. Countries: 10. Publications: 3.
Screening of Liver Fibrosis in Adults Without Known Liver Disease
ClinicalTrials.gov study NCT05486767. IPD Sharing: YES. Countries: 1. Publications: 1.
A Study of Experimental Medication BMS-986036 in Adults With Nonalcoholic Steatohepatitis (NASH) and Stage 3 Liver Fibrosis
ClinicalTrials.gov study NCT03486899. IPD Sharing: Not stated. Countries: 2. Publications: 3.
Sonoelastography: Ultrasound Method to Measure Liver Fibrosis
ClinicalTrials.gov study NCT01747772. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Liver Fibrosis in Zambian HIV-HBV Co-infected Patients
ClinicalTrials.gov study NCT02344680. IPD Sharing: NO. Countries: 1. Publications: 33.
Safety and Efficacy of Simtuzumab (SIM, GS-6624) in Adults With Advanced Liver Fibrosis But Not Cirrhosis Secondary to Non-Alcoholic Steatohepatitis (NASH)
ClinicalTrials.gov study NCT01672866. IPD Sharing: Not stated. Countries: 9. Publications: 3.
AURORA: A Study for the Efficacy and Safety of Cenicriviroc (CVC) for the Treatment of Liver Fibrosis in Adults With Nonalcoholic Steatohepatitis (NASH)
ClinicalTrials.gov study NCT03028740. IPD Sharing: Not stated. Countries: 28. Publications: 1.
Liver Fibrosis Assessment in Diabetic Patients
ClinicalTrials.gov study NCT06694974. IPD Sharing: NO. Countries: 1. Publications: 10.
Clinical Trial to Evaluation the Safety and Efficacy of GR-MD-02 for the Treatment of Liver Fibrosis and Resultant Portal Hypertension in Patients With Nash Cirrhosis
ClinicalTrials.gov study NCT02462967. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Ultrasound Method to Measure Fibrosis of the Liver in Children
ClinicalTrials.gov study NCT02086708. IPD Sharing: UNDECIDED. Countries: 1. Publications: 1.
Efficacy and Safety Study of Cenicriviroc for the Treatment of Nonalcoholic Steatohepatitis (NASH) in Adult Participants With Liver Fibrosis
ClinicalTrials.gov study NCT02217475. IPD Sharing: Not stated. Countries: 10. Publications: 6.
Identification of Fatty Liver With Advanced Fibrosis in Type 2 Diabetes Using Simple Fibrosis Scores and Electronic Reminder Messages
ClinicalTrials.gov study NCT04241575. IPD Sharing: YES. Countries: 1. Publications: 1.
Liver transcriptome analysis reveals PSC-attributed gene set associated with fibrosis progression
Open the record for dataset details and reuse information.
Statistics "Polyenylphosphatidylcholines as bioactive excipient in tablets for the treatment of liver fibrosis"
<p>Details to the statistics for the "Polyenylphosphatidylcholines as bioactive excipient in tablets for the treatment of liver fibrosis"</p>
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.