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39 results for “locus coeruleus”
Locus coeruleus activity strengthens prioritized memories under arousal
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Data Related to Osorio-Forero, Foustoukos, Cardis et al., "Noradrenergic locus coeruleus activity functionally partitions NREMS to gatekeep the NREM-REM cycle"
<p>This Zenodo Upload contains the Transparent Data Files for an updated version of the manuscript currently published in Nature Neuroscience</p> <p>and entitled </p> <p><em>'</em>Infraslow noradrenergic locus coeruleus activity fluctuations control are gatekeepers of the NREM–REM sleep cycle' </p> <p>published by the authors as indicated in the author list.</p>
Cellular composition and circuit organization of mouse locus coeruleus
<p>The locus coeruleus (LC) houses the vast majority of noradrenergic neurons in the brain and regulates many fundamental functions including fight and flight response, attention control, and sleep/wake cycles. While efferent projections of the LC have been extensively investigated, little is known about its local circuit organization. Here, we performed large-scale multi-patch recordings of noradrenergic neurons in adult mouse LC to profile their morpho-electric properties while simultaneously examining their interactions. LC noradrenergic neurons are diverse and could be classified into two major morpho-electric types. While fast excitatory synaptic transmission among LC noradrenergic neurons was not observed in our preparation, these mature LC neurons connected via gap junction at a rate similar to their early developmental stage and comparable to other brain regions. Most electrical connections form between dendrites and are restricted to narrowly spaced pairs or small clusters of neurons of the same type. In addition, more than two electrically coupled cell pairs were often identified across a cohort of neurons from individual multi-cell recording sets that followed a chain-like organizational pattern. The assembly of LC noradrenergic neurons thus follows a spatial and cell type-specific wiring principle that may be imposed by a unique chain-like rule.</p>
The locus coeruleus broadcasts prediction errors across the cortex to promote sensorimotor plasticity
<p>Raw data and code to generate the figures of the publication "The locus coeruleus broadcasts prediction errors across the cortex to promote sensorimotor plasticity" <a href="https://doi.org/10.7554/eLife.85111.2">https://doi.org/10.7554/eLife.85111</a>. </p>
Cellular composition and circuit organization of mouse locus coeruleus
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Data from: Pathways underlying selective neuronal vulnerability in Alzheimer's disease: Contrasting the vulnerable locus coeruleus to the resilient substantia nigra
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Raw recordings for electrophysiological characterization of CNO-DREADD mediated responses in noradrenergic locus coeruleus (LC) neurons from lines RR1(P), RR2(P), and RC::FPDi (P).
<p>Whole-cell recordings were performed as described previously by the Jiang lab. Briefly, patch pipettes (2-7 MΩ) were filled with an internal solution containing 120 mM potassium gluconate, 10 mM HEPES, 4 mM KCl, 4 mM MgATP, 0.3 mM Na<sub>3</sub>GTP, 10 mM sodium phosphocreatine and 0.5% biocytin (pH 7.25). Whole-cell recordings from up to 8 LC neurons were performed using two Quadro EPC 10 amplifiers (HEKA Electronic, Germany). PatchMaster (HEKA) and custom-written Matlab-based programs (Mathworks) were used to operate the recording system and perform online and offline data analysis. In current-clamp recordings, neurons were first current clamped at ~-40pA to prevent spontaneous firing. Prior to investigating the effect of drugs, we calculated spike thresholds and recorded firing patterns in response to sustained depolarizing currents by injecting increasing current steps (+10pA). Continuous recordings were obtained from LC neurons current clamped at -40 to 0 pA during drug wash-on experiments. We also calculated other intrinsic electrophysiological parameters, such as the input resistance, membrane time constant, spike amplitude, after-hyperpolarization (AHP) etc.</p>
Locus coeruleus activity improves cochlear implant performance
<p>Data set for: Glennon E, Valtcheva S, Zhu A, Wadghiri YZ, Svirsky MA, Froemke RC. Locus coeruleus activity improves cochlear implant performance. Nature. <em>Provisionally accepted.</em></p> <p>Each file contains the source data for individual figures. </p>
Data from: Locus coeruleus neuromelanin predicts ease of attaining and maintaining neural states of arousal
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Data from: Noradrenergic projections from the locus coeruleus to the amygdala constrain fear memory reconsolidation
<p>Memory reconsolidation is a fundamental plasticity process in the brain that allows established memories to be changed or erased. However, certain boundary conditions limit the parameters under which memories can be made plastic. Strong memories do not destabilize, for instance, although why they are resilient is mostly unknown. Here, we extend the understanding of the mechanisms implicated in reconsolidation-resistant memories by<i> </i>investigating the hypothesis that specific modulatory signals shape memory formation into a state that lacks lability. We find that the activation of the noradrenaline-locus coeruleus system (NOR-LC) during strong fear memory encoding increases molecular mechanisms of stability at the expense of lability in the amygdala. Preventing the NOR-LC from modulating strong fear encoding results in the formation of memories that can undergo reconsolidation within the amygdala and thus are vulnerable to post-reactivation interference. Thus, the memory strength boundary condition on reconsolidation is set at the time of encoding by the action of the NOR-LC.</p>
Locus Coeruleus firing patterns selectively modulate brain activity and dynamics
<p>This dataset supports the manuscript entitled 'Locus Coeruleus firing patterns selectively modulate brain activity and dynamics' (https://doi.org/10.1101/2022.08.29.505672). Please refer to this manuscript for detailed information. </p> <p>The dataset contains a total of 81 functional (GE-BOLD) and 30 anatomical (T1-weighted) scans of ChR2-expressing C57BL/6-Tg(<em>Dbh</em>-iCre)1Gsc mice in NIFTI format, multiplied by 10. Mice were optogenetically stimulated with blue light in the right Locus Coeruleus in a 3Hz tonic, 5Hz tonic, and 15Hz burst pattern. Sham stimulation entailed red light stimulation at a 5Hz tonic frequency. The 'StimulationProtocol' text file specifies the precise onset (in seconds, minus 10 seconds for dummy scans) and duration (in seconds) of the different optogenetic stimulation protocols during a 1440 seconds functional scan. The 'SubjectDetails' file lists the subject IDs, their gender, their genotype, the stimulation type of functional scans, and their associated anatomical scan.</p>
Spatial Transcriptomics data (GeoMx) of locus coeruleus dopamine cells in control and PD subjects
<p>The repository includes Spatial Transcriptomic datasets generated by Nanostring GeoMx (Hu WTA) analysis of locus coeruleus TH+ cells from Controls (n=9), early Parkinsons Disease (ePD, n=8) and late Parkinsons Disease (lPD, n=2). A total 39 Regions of Interest were analysed. The raw and processed counts and metadata are provided as an R Seurat object (geomx_vila_thmask.rds). The scripts used for low level data processing are described in https://github.com/zchatt/ASAP-SpatialTranscriptomics/blob/main/geomx/lowlevel/README.md.</p> <p>Tissue samples from pathologically confirmed stage IV Lewy body PD (early-PD), stage VI Lewy body PD (late-PD)(Braak, Del Tredici et al. 2003) and controls without the neurological or neuropathological disease were obtained from the Sydney Brain Bank. The study was approved by the University of Sydney Human Research Ethics Committee (2021/845). All cases with PD were levodopa-responsive and fulfilled the UK Brain Bank Clinical Criteria for a diagnosis of clinical PD (Hughes, Ben-Shlomo et al. 1992) with no other neurodegenerative conditions. </p> <p>Cells were not extracted. Tissue sections were cut from FFPE blocks of post-mortem human midbrains at 6µm on a rotary microtome (HistoCore MULTICUT, Leica Biosystems) and mounted on Series 2 adhesive microscope slides (Trajan Scientific Medical, AU) for processing for spatial trranscriptomics. To remove the paraffin, slides were incubated in the oven at 60°C for 1hr and then submerged in HistoChoice Clearing Agent (Sigma-Aldrich, H2779) for 2x7mins, followed by rehydration in decreasing ethanol concentrations (100% ethanol for 2x3mins, 95% ethanol for 3mins, 70% ethanol for 3mins) and distilled H2O for 3mins. </p> <p>Tissue sections were immunohistochemically stained for tyrosine hydroxylase and Regions of Interest (ROIs) processed following Nanostring GeoMx® Digital Spatial Profiler using the manufacturer’s instructions. Libraries were sequenced on Illumina Novaseq 6000 platform using NovaSeq SP 100 cycle kit (XP workflow, 27-8-8-27).</p> <p>This research was funded in whole or in part by Aligning Science Across Parkinson’s (ASAP-020505) through the Michael J. Fox Foundation for Parkinson’s Research (MJFF). For the purpose of open access, the author has applied a CC BY 4.0 public copyright license to all Author Accepted Manuscripts arising from this submission.</p>
Milnacipran in Autism and the Functional Locus Coeruleus and Noradrenergic Model of Autism
ClinicalTrials.gov study NCT01337700. IPD Sharing: Not stated. Countries: 1. Publications: 0.
Understanding the Role of the Locus Coeruleus in Insomnia
ClinicalTrials.gov study NCT07392177. IPD Sharing: YES. Countries: 1. Publications: 0.
Data from: Noradrenergic projections from the locus coeruleus to the amygdala constrain fear memory reconsolidation
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Pathogenic tau in the mouse locus coeruleus produces noradrenergic hyperactivity and neuropsychiatric phenotypes reminiscent of prodromal Alzheimer’s disease
GEO Series GSE314950. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Tyrosinase-induced neuromelanin accumulation triggers rapid dysregulation and degeneration of the mouse locus coeruleus
GEO Series GSE226827. Mus musculus. 22 samples. Type: Expression profiling by high throughput sequencing.
Generation of Locus Coeruleus Norepinephrine Neurons from Human Pluripotent Stem Cells [snRNA-seq]
GEO Series GSE221988. Homo sapiens. 3 samples. Type: Expression profiling by high throughput sequencing.
Transcriptional interaction network analyses in dorsal nucleus of vagus nerve, locus coeruleus and substantia nigra in Parkinson's disease
GEO Series GSE43490. Homo sapiens. 41 samples. Type: Expression profiling by array.
Molecular and functional sex differences of noradrenergic neurons in the mouse locus coeruleus [Illumina]
GEO Series GSE100004. Mus musculus. 30 samples. Type: Other.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.