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167 results for “long-term care”
Data for "Long-term disgust habituation with limited generalisation in care home workers"
<p>Anonymised data for the manuscript "Long-term disgust habituation with limited generalisation in care home workers". For use with scripts in the linked GitHub repository.</p>
Temporal and regional trends of antibiotic use in long-term aged care facilities across 39 countries, 1985-2019: systematic review and meta-analysis
<p><b>Background</b></p> <p>Antibiotic misuse is a key contributor to antimicrobial resistance and a concern in long-term aged care facilities (LTCFs). Our objectives were to: i) summarise key indicators of systemic antibiotic use and appropriateness of use, and ii) examine temporal and regional variations in antibiotic use, in LTCFs (PROSPERO registration CRD42018107125).</p> <p><b>Methods & Findings</b></p> <p>Medline and EMBASE were searched for studies published between 1990-2021 reporting antibiotic use rates in LTCFs. Random effects meta-analysis provided pooled estimates of antibiotic use rates (percentage of residents on an antibiotic on a single day [point prevalence] and over 12 months [period prevalence]; percentage of appropriate prescriptions). Meta-regression examined associations between antibiotic use, year of measurement and region. </p> <p>A total of 90 articles representing 78 studies from 39 countries with data between 1985-2019 were included. Pooled estimates of point prevalence and 12-month period prevalence were 5.2% (95% CI: 3.3-7.9; n=523,171) and 62.0% (95% CI: 54.0-69.3; n=946,127), respectively. Point prevalence varied significantly between regions (Q=224.1, df=7, p<0.001), and ranged from 2.4% (95% CI: 1.7-2.7) in Eastern Europe to 9.0% in the British Isles (95% CI: 7.6-10.5) and Northern Europe (95% CI: 7.7-10.5). Twelve-month period prevalence varied significantly between region (Q=15.1, df-3, p=0.002) and ranged from 53.9% (95% CI: 48.3-59.4) in the British Isles to 68.3% (95% CI: 63.6-72.7) in Australia. Meta-regression found no association between year of measurement and antibiotic use prevalence. The pooled estimate of the percentage of appropriate antibiotic prescriptions was 28.5% (95% CI: 10.3-58.0; n=17,245) as assessed by the McGeer criteria. Year of measurement was associated with decreasing appropriateness of antibiotic use over time (OR: 0.78, 95% CI: 0.67-0.91). The most frequently used antibiotic classes were penicillins (n=44 studies), cephalosporins (n=36), sulphonamides/trimethoprim (n=31), and quinolones (n=28). </p> <p><b>Conclusions</b></p> <p>Coordinated efforts focusing on LTCFs are required to address antibiotic misuse in LTCFs. Our analysis provides overall baseline and regional estimates for future monitoring of antibiotic use in LTCFs. </p>
Wild kangaroos become more social when caring for young and may maintain long-term affiliations with popular individuals
<p>Kangaroos are an iconic group of Australian fauna. Despite considerable research on kangaroo behaviour, key gaps remain in our understanding of their social organization in the wild. In particular, it remains largely unknown whether kangaroos form long-term social bonds and what factors might prompt individuals to associate or dissociate from one another. Over 6 years, we monitored the social affiliations of individually identified eastern grey kangaroos, Macropus giganteus, in a large wild population. We investigated the short-term and long-term relationships of kangaroos and the extent those relationships varied with age, sex and reproductive state. We found evidence that long-term relationships among eastern grey kangaroos are possible, especially between adult females. Those individuals that were more sociable within years were also more likely to establish affiliations across years. Contrary to previous studies, we observed females actively associating with other mothers in the years in which they had young. These data suggest that the fission-fusion dynamics of eastern grey kangaroo social behaviour allow females to modulate their social position with conspecifics according to their current reproductive state. We highlight the adaptive implications of the formation of long-term bonds and the changes in social behaviour observed in females.</p>
Molecular epidemiology and risk factors for extended-spectrum β-lactamase-producing Enterobacterales in long-term care residents
<div class="abstract-content selected"> <p><strong class="sub-title"> Objectives: </strong> We aimed to assess the burden of extended-spectrum β-lactamase (ESBL)-producing Enterobacterales in Swiss long-term care facilities (LTCFs) to describe the molecular epidemiology, describe the intra-institutional and regional clusters of resistant pathogens, and identify independent institution- and resident-level factors associated with colonization.</p> <p><strong class="sub-title"> Design: </strong> Cross-sectional study.</p> <p><strong class="sub-title"> Setting and participants: </strong> From August to October 2019, we performed a point prevalence study among residents from 16 LTCFs in Western and Eastern Switzerland (8 per region).</p> <p><strong class="sub-title"> Methods: </strong> Residents underwent screening for ESBL-producing Enterobacterales (ESBL-E); whole-genome sequencing (WGS) was performed. We gathered institution-level (eg, number of beds, staff-resident ratio, alcoholic hand rub consumption) and resident-level [eg, anthropometric data, time in facility, dependency, health care exposure, antibiotic treatment, proton-pump inhibitor (PPI) use] characteristics. Factors associated with colonization were identified using a generalized linear model.</p> <p><strong class="sub-title"> Results: </strong> Among 1185 eligible residents, 606 (51%) consented to the study. ESBL-E prevalence was 11.6% (70/606), ranging from 1.9% to 33.3% between institutions, with a median of 12.5% in the West and 6.9% in the East (P = .03). Among 59 <em>Escherichia</em> <em>coli</em> (from 58 residents), multilocus sequence type (ST) 131 was most common (n = 43/59, 73%), predominantly its subclone H30R1 (n = 37/43, 86%). WGS data identified multiple intra-institutional and regional clusters. Independent risk factors for ESBL carriage were previous ESBL colonization [adjusted odds ratio (aOR) 23.5, 95% confidence interval (CI) 6.6–83.8, P < .001), male gender (aOR 2.6, 95% CI 1.5–4.6, P = .002), and use of PPIs (aOR 2.2, 95% CI 1.2–3.8, P = .01).</p> <p><strong class="sub-title"> Conclusions and implications: </strong> Overall ESBL-E prevalence in Swiss LTCF residents is low. Yet, we identified several clusters of residents with identical pathogens within the same institution. This implies that particularly affected institutions might benefit from targeted infection control interventions. PPI use was the only modifiable factor associated with carriage of ESBL producers. This study adds to the growing list of adverse outcomes associated with PPIs, calling for action to restrict their use in the long-term care setting.</p> </div>
Vitamin D Supplementation and Acute Respiratory Infection in Older Long-Term Care Residents
ClinicalTrials.gov study NCT01102374. IPD Sharing: NO. Countries: 1. Publications: 1.
CONFIDENT: Supporting Long-term Care Workers During COVID-19
ClinicalTrials.gov study NCT05168800. IPD Sharing: YES. Countries: 1. Publications: 2.
Effects of Acupunch Exercises on the Frail Older Adults in Long-Term Care Facilities
ClinicalTrials.gov study NCT04481438. IPD Sharing: NO. Countries: 1. Publications: 3.
Airway Limitation Study: Study In Primary Care Centers Of Chronic Bronchitis In Long-Term Cigarette Smokers Of At Least 40 Years Of Age With Symptoms Of Cough And Shortness Of Breath
ClinicalTrials.gov study NCT00442468. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Targeted Infection Control in Long-term Care
ClinicalTrials.gov study NCT01062841. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Antihypertensive Deprescribing in Long-term Care
ClinicalTrials.gov study NCT05047731. IPD Sharing: YES. Countries: 1. Publications: 1.
Alzheimer's in Long-Term Care--Treatment for Agitation
ClinicalTrials.gov study NCT00161473. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Evaluating the Effectiveness of a Stepped-Care Approach to Long-Term Weight Loss (The Step-Up Study)
ClinicalTrials.gov study NCT00714168. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Temporal and regional trends of antibiotic use in long-term aged care facilities across 39 countries, 1985-2019: systematic review and meta-analysis
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Wild kangaroos become more social when caring for young and may maintain long-term affiliations with popular individuals
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Molecular epidemiology and risk factors for extended-spectrum β-lactamase-producing Enterobacterales in long-term care residents
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Data from: Health services intervention integrating HTN and HIV care improves long-term blood pressure control among people living with HIV in Uganda
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Table e-1: Supplementary materials for association of dementia-related psychosis with long-term care use and death
<p>International Classification of Diseases, Ninth and Tenth Revisions, Clinical Modification codes for dementia, codes used to define exclusions for conditions potentially associated with psychosis, codes for manifestations of psychosis used to establish presence of dementia-related psychosis, and antipsychotic medications.</p> <p>The dataset is a collection of ICD-9 and -10 codes usedd to define exclusions for conditions potentially associated with psychosis, codes for manifestations of psychosis used to establish presence of dementia-related psychosis, and antipsychotic medications used in the analysis of the attached manuscript.</p> <p>Data in this table was used to conduct the analyses presented in the manuscript.</p>
Long-term health-related quality of life, healthcare utilisation and back-to-work activities in Intensive Care Unit survivors: prospective confirmatory study from the Frisian Aftercare Cohort
<p>More substantial information on recovery after Intensive Care Unit (ICU) admission is urgently needed. In a previous retrospective study, the proportion of non-recovery patients was 44%. The aim of this prospective follow-up study was to evaluate changes Health-Related Quality of Life (HRQoL) in the first year after ICU-admission. Long-stay adult ICU-patients (≥ 48 hours) were included. HRQoL was evaluated with the Dutch translation of the RAND-36 item Health Survey (RAND-36) at baseline via proxy measurement, and at three, six, and twelve months after ICU admission. Subsequently, the relation between physical functioning, healthcare utilisation, and work activities was explored. </p>
Dataset for the validation of the Delirium Observation Screening Scale in long-term care facilities in Flanders
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Resourcing long-term care: A social investment approach
<p>This video explores decision-making for investments in long-term care.</p>
ScienceDex guides
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.