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99 results for “long-term immunity”
Long-term immunity against yellow fever in children vaccinated during infancy: a longitudinal cohort study
<p>The data represent the concentrations of specific neutralizing antibodies following infant immunization against yellow fever. We used a microneutralization assay to measure protective antibodies against yellow fever virus in 587 Malian and 436 Ghanaian children vaccinated around age 9 months, and followed for 4.5 years (Mali), or 2.5 and 6 years (Ghana). We standardized antibody concentrations with reference to the yellow fever WHO International Standard.</p> <p>The serum samples used in this study, and the sample metadata included in the present dataset originate from trials of the meningococcal group A conjugate vaccine, MenAfriVac, namely the PsATT-004 (phase II) and Pers-004 (phase IV) studies in Ghana, and the PsATT-007 (phase III) and Pers-007 (phase IV) studies in Mali (clinical trial registry numbers ISRCTN82484612, ISRCTN10763234, PACTR201110000328305, and ISRCTN37623829). MenAfriVac was developed by PATH and Serum Institute India Pvt. Ltd. (SIIPL).</p> <p>This dataset consists of three files:</p> <p>1. Ghana group data | Tab-delimited text file: Yellow_fever_nAb_Ghana.csv</p> <p>2. Mali group data | Tab-delimited text file: Yellow_fever_nAb_Mali.csv</p> <p>3. Data dictionary | PDF file: Yellow_fever_nAb_Data_Dictionary.pdf</p> <p> </p> <p> </p> <p> </p> <p> </p> <p> </p>
Data from: Single cell RNA-seq analysis reveals that prenatal arsenic exposure results in long-term, adverse effects on immune gene expression in response to Influenza A infection
<p>Arsenic exposure via drinking water is a serious environmental health concern. Epidemiological studies suggest a strong association between prenatal<i> </i>arsenic exposure and subsequent childhood respiratory infections, as well as morbidity from respiratory diseases in adulthood, long after systemic clearance of arsenic.<i> </i>We investigated the impact of exclusive prenatal arsenic exposure on the inflammatory immune response and respiratory health after an adult influenza A (IAV) lung infection. C57BL/6J mice were exposed to 100 ppb sodium arsenite<i> in utero,</i> and subsequently infected with IAV (H1N1) after maturation to adulthood. Assessment of lung tissue and bronchoalveolar lavage fluid (BALF) at various time points post IAV infection reveals greater lung damage and inflammation in arsenic exposed mice versus control mice. Single-cell RNA sequencing analysis of immune cells harvested from IAV infected lungs suggests that the enhanced inflammatory response is mediated by dysregulation of innate immune function of monocyte derived macrophages, neutrophils, NK cells, and alveolar macrophages. Our results suggest that prenatal arsenic exposure results in lasting effects on the adult host innate immune response to IAV infection, long after exposure to arsenic, leading to greater immunopathology. This study provides the first direct evidence that exclusive prenatal exposure to arsenic in drinking water causes predisposition to a hyperinflammatory response to IAV infection in adult mice, which is associated with significant lung damage.</p>
A Study to Test GlaxoSmithKline's (GSK) Herpes Zoster (HZ) Subunit Vaccine's Long-term Immune Response in Previously Vaccinated Kidney Transplant Adults and Then to Test if 2 Additional Doses of the V
ClinicalTrials.gov study NCT04176939. IPD Sharing: YES. Countries: 7. Publications: 0.
Long-term Persistence of Immunity Against Hepatitis B in 7-8 Years Old Children After Hepatitis B Vaccination.
ClinicalTrials.gov study NCT00519649. IPD Sharing: YES. Countries: 1. Publications: 1.
Evaluation of the Long-term Persistence of Immunity to Hepatitis B, in Adolescents Vaccinated in Infancy With Engerix™-B Kinder
ClinicalTrials.gov study NCT01847430. IPD Sharing: YES. Countries: 1. Publications: 1.
Study Evaluating Prevnar Infant Long-term Immune Response Versus Prevnar Naive Cohort
ClinicalTrials.gov study NCT00824850. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Long-term Study of Romiplostim in Thrombocytopenic Pediatric Patients With Immune Thrombocytopenia (ITP)
ClinicalTrials.gov study NCT02279173. IPD Sharing: YES. Countries: 17. Publications: 2.
Long-Term Immune Persistence of GlaxoSmithKline Biologicals' Inactivated Hepatitis A Vaccine, Injected According to 0, 6-month Schedule
ClinicalTrials.gov study NCT00289757. IPD Sharing: YES. Countries: 1. Publications: 7.
Efficacy of Different COVID-19 Vaccine Combinations in Inducing Long-term Humoral Immunity [PRIBIVAC]
ClinicalTrials.gov study NCT05142319. IPD Sharing: NO. Countries: 1. Publications: 6.
Long-Term Immune Persistence of GSK Biologicals' Combined Hepatitis A & B Vaccine Injected According to a 0,1,6 Month Schedule
ClinicalTrials.gov study NCT00289718. IPD Sharing: YES. Countries: 1. Publications: 3.
A Study Evaluating the Safety and Efficacy of Long-term Dosing of Romiplostim in Thrombocytopenic Pediatric Patients With Immune (Idiopathic) Thrombocytopenia Purpura
ClinicalTrials.gov study NCT01071954. IPD Sharing: Not stated. Countries: 4. Publications: 1.
Long-Term Immune Persistence of GlaxoSmithKline Biologicals' Inactivated Hepatitis A Vaccine Injected According to a 0, 12-month Schedule
ClinicalTrials.gov study NCT00291876. IPD Sharing: YES. Countries: 1. Publications: 5.
Long-term Persistence of Immunity to Hepatitis B in Adults Vaccinated With GlaxoSmithKline (GSK) Biologicals' Hepatitis B Vaccine (HBV), Engerix-B
ClinicalTrials.gov study NCT02901951. IPD Sharing: YES. Countries: 2. Publications: 1.
Long-term Immune Persistence of GSK Biologicals' Combined Hepatitis A & B Vaccine Injected According to a 0,1,6 Mth Schedule in Healthy Adults
ClinicalTrials.gov study NCT00289770. IPD Sharing: YES. Countries: 1. Publications: 3.
Data from: Single cell RNA-seq analysis reveals that prenatal arsenic exposure results in long-term, adverse effects on immune gene expression in response to Influenza A infection
Open the record for dataset details and reuse information.
Long-term memory T cells as preventive anticancer immunity elicited by TuA-derived heteroclitic peptides
<p>The host’s immune system may be primed against antigens during the lifetime (e.g. microorganisms antigens—MoAs), and swiftly<br> recalled upon growth of a tumor expressing antigens similar in sequence and structure. C57BL/6 mice were immunized in a preventive<br> setting with tumor antigens (TuAs) or corresponding heteroclitic peptides specific for TC-1 and B16 cell lines. AQ1 Immediately or 2-<br> months after the end of the vaccination protocol, animals were implanted with cell lines. The specific anti-vaccine immune response as<br> well as tumor growth were regularly evaluated for 2 months post-implantation. The preventive vaccination with TuA or their<br> heteroclitic peptides (hPep) was able to delay (B16) or completely suppress (TC-1) tumor growth when cancer cells were implanted<br> immediately after the end of the vaccination. More importantly, TC-1 tumor growth was significantly delayed, and suppressed in 6/8<br> animals, also when cells were implanted 2-months after the end of the vaccination. The vaccine-specific T cell response provided a<br> strong immune correlate to the pattern of tumor growth. A preventive immunization with heteroclitic peptides resembling a TuA is able<br> to strongly delay or even suppress tumor growth in a mouse model. More importantly, the same effect is observed also when tumor<br> cells are implanted 2 months after the end of vaccination, which corresponds to 8 – 10 years in human life. The observed potent tumor<br> control indicates that a memory T cell immunity elicited during the lifetime by a antigens similar to a TuA, i.e. viral antigens, may<br> ultimately represent a great advantage for cancer patients and may lead to a novel preventive anti-cancer vaccine strategy.</p>
A novel immune-related prognostic signature based on Chemoradiotherapy sensitivity predicts long-term survival in patients with esophageal squamous cell carcinoma.
<p>Raw Data for PeerJ</p>
Duration of Long-term Immunity After Hepatitis B Virus Immunization
ClinicalTrials.gov study NCT01182311. IPD Sharing: Not stated. Countries: 1. Publications: 4.
A Long-term Safety Study of Eltrombopag in Pediatric Patients With Chronic Immune (Idiopathic) Thrombocytopenic Purpura (ITP)
ClinicalTrials.gov study NCT02201290. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Safety and Long-term Evaluation (up to 5 Years) of First Booster Immunization With Novartis' TBE Vaccine for Adults in Adolescents and Adults
ClinicalTrials.gov study NCT00387634. IPD Sharing: Not stated. Countries: 1. Publications: 1.
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Allen Brain Atlas
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International Brain Laboratory public data
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OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.