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ShareScore release 0.9.0
Dataset results
11 results for “loxP”
Data from: Cre-mediated, loxP independent sequential recombination of a tripartite transcriptional stop cassette allows for partial read-through transcription
<p>One of the widely used applications of the popular Cre-loxP method for targeted recombination is the permanent activation of marker genes, such as reporter genes or antibiotic resistance genes, by excision of a preceding transcriptional stop signal. The STOP cassette consists of three identical SV40-derived poly(A) signal repeats and is flanked by two loxP sites. We found that in addition to complete loxP-mediated recombination, limiting levels of the Cre recombinase also cause incomplete recombination of the STOP cassette. Partial recombination leads to the loss of only one or two of the three identical poly(A) repeats with recombination breakpoints always precisely matching the end/start of each poly(A) signal repeat without any relevant similarity to the canonical or known cryptic loxP sequences, suggesting that this type of Cre-mediated recombination is loxP-independent. Incomplete deletion of the STOP cassette results in partial read-through transcription, explaining at least some of the variability often observed in marker gene expression from an otherwise identical locus.</p>
Data from: Cre-mediated, loxP independent sequential recombination of a tripartite transcriptional stop cassette allows for partial read-through transcription
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Differentially expressed RNA levels in the liver of aged LoxP and SIRT2-KOhep mice
GEO Series GSE228204. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Comparison of small RNA profiling in sperm susceptible or not susceptible to epigenetic silencing of the LoxP site
GEO Series GSE97971. Mus musculus. 4 samples. Type: Non-coding RNA profiling by high throughput sequencing.
RNA sequencing (RNA-SEQ) of BUD31 knockout by cre-loxp in the mouse reproductive system
GEO Series GSE189714. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Next Generation Sequencing of Loxp (Rxratm1Krc/J,Rxra loxP), Hetero(Nex-cre;Rxratm1Krc/J,Rxra cKO-Het) and cKO (Nex-cre;Rxratm1Krc/J,Rxra cKO) mouse Transcriptomes
GEO Series GSE136788. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Gene Expression data from LPS (2 hour) - treated PPP2CA alpha conditional knockout Bone Marrow Derived Macrophages (PP2ACαfl/fl;lyM-Cre, cre-loxp mediated exon1 deletion in myeloid cells)
GEO Series GSE83517. Mus musculus. 4 samples. Type: Expression profiling by array.
RNAseq comparing mouse Cre-loxP-induced EWSR1-ATF1 expression from Rosa26 versus Ewsr1-Atf1 translocation
GEO Series GSE158725. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Cre-loxP-induced Ewsr1-Atf1 translocation tumors
GEO Series GSE158726. Mus musculus. 25 samples. Type: Expression profiling by high throughput sequencing; Other.
Low read depth whole genome sequencing of mouse Cre-loxP-induced Ewsr1-Atf1 translocation tumors
GEO Series GSE158719. Mus musculus. 5 samples. Type: Other.
RNAseq from mouse Cre-loxP-induced Ewsr1-Atf1 translocation
GEO Series GSE158720. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.