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783 results for “lung adenocarcinoma”
Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma
<p>Code and data for the MS <strong>"Ultrasensitive ctDNA detection for preoperative disease stratification in early-stage lung adenocarcinoma"</strong></p>
MicroRNA Panel Predicts Lung Adenocarcinoma in Patients Presenting with Ground-Glass Nodules
<p>MicroRNA (miRNA) expression is correlated with tumor histology, differentiation, invasiveness and treatment outcome. We aimed to identify miRNAs whose differential expression might enable early diagnosis of lung adenocarcinoma in patients presenting with ground-glass nodules (GGNs). To identify potential miRNAs of interest, we analyzed the miRNA expression profile of tumor and adjacent non para-tumor tissue in 3 participants by next-generation sequencing (NGS). We then assessed the expression levels of the miRNAs of interest in 73 lung adenocarcinoma presenting with GGNs with matched adjacent non-tumor tissue by quantitative real-time polymerase chain reaction (qRT-PCR). Target genes of our selected miRNA panel were predicted using Miranda with default parameters. Twenty-three miRNAs showed differential expression between tumor and adjacent non-tumor tissue by NGS. Five miRNAs exhibited higher expression in tumor tissue compared to adjacent non-tumor tissue (P＜0.05), eighteen miRNAs demonstrated lower expression in tumor tissue versus adjacent non-tumor tissue (P＜0.05). When qRT-PCR was performed for the 23 miRNAs identified by NGS in the pilot stage, seven were found to have statistically significant expression in tumor versus adjacent non-tumor tissue (P＜0.05). The predicted targets of our miRNAs of interest are frequently associated with cancer signaling pathways. We developed a miRNA panel that could potential predict the presence of lung adenocarcinoma in patients presenting with GGNs. </p>
Single-cell RNA-seq profiles of lung adenocarcinoma patients and tumor-bearing mice
<p>single-cell RNA sequencing (scRNA-seq) profiles from eight patients with lung adenocarcinoma (LUAD) and four samples of tumor tissues from tumor bearing mice were performed. By integrating other scRNA-seq data and clinical information, we identified activated adaptive immune responses in older patients, reflected by enriched dysfunctional T cell signature scores and immune checkpoint molecules. Our study shows increased efficacy of immune checkpoint blockade therapy in older patients, addressing the prominent role of age when considering immunotherapy.</p>
Intratumoural heterogeneity and immune modulation in lung adenocarcinoma of female smokers and never smokers
<p>Count matrix and associated meta data for single nucleus transcriptomics of healthy and tumour lung tissue from lung adenocarcinoma patients. Cohort includes young and elderly, female and male, smokers and never smokers.</p>
Single-cell and single-nucleus RNA-sequencing from paired normal-adenocarcinoma lung samples provides both common and discordant biological insights
<p>The datasets generated by <em>Cellranger </em>for all 24 samples (.h5 format).<br><br></p>
Machine learning and bioinformatics analysis of diagnostic biomarkers associated with the occurrence and development of lung adenocarcinoma
Open the record for dataset details and reuse information.
Single-cell and spatial transcriptomics delineate molecular traits and immunosuppressive landscape during histological progression of lung adenocarcinoma
<p>Two specimens of lung adenocarcinoma, each corresponding to the lepidic and solid histologic patterns as confirmed through histologic scrutiny, were procured in accordance with standard surgical protocols. These specimens underwent a process of formalin fixation and were subsequently encapsulated within paraffin-embedded tissue blocks. The specimens were then sectioned and subjected to hematoxylin and eosin (H&E) staining to facilitate subsequent imaging at a resolution of 40x (equivalent to 0.25 micron/pixel) via the use of Aperio GT450 scanners. The tissue slides were then conveyed to the Genomics core, where following the decoverslipping of the tissue, the Visium CytAssist device was employed to transfer transcriptomic probes from the original glass slides to capture areas on Visium slides measuring 11mm x 11mm. Comprehensive transcriptomic profiling was achieved post mRNA permeabilization, through poly(A) capture and probe hybridization. The resultant libraries were sequenced utilizing the Illumina Novaseq 6000, using paired-end sequencing with a read length of 150 base pairs.</p>
Data and analysis scripts for: Lung adenocarcinoma promotion by air pollutants
<p>Code for "Lung adenocarcinoma promotion by air pollutants" manuscript</p> <p>egfrm_lc_incidence</p> <ul> <li>Epidemiological analyses of EGFRm lung cancer incidence and PM2.5 levels in England (NHS England), South Korea and Taiwan.</li> </ul> <p>ukbb</p> <ul> <li>Epidemiological analyses of lung cancer incidence and PM2.5 levels in England, using the UKBB data set.</li> </ul> <p>mouse_RNA_seq</p> <ul> <li>Analysis of RNA-seq data derived from lung tumour tissue of pollution-exposed mice.</li> </ul> <p>mouse_WGS</p> <ul> <li>Analysis of WGS data derived from lung tumour tissue of pollution-exposed mice.</li> </ul> <p>normal_lung</p> <ul> <li>Analysis of ddPCR for EGFRm from normal lung tissue from the TRACERx and PEACE cohorts.</li> <li>Analysis of Duplex-seq data from normal lung tissue from the PEACE and BDRE cohorts.</li> </ul>
Data from: Combined analysis of micro RNA and proteomic profiles and interactions in patients with primary lung adenocarcinoma and lung adenocarcinoma brain metastases
<p>We carried out an analysis of miRNAs expression profiles and protein spectrums of non-metastatic primary lung adenocarcinoma (LP) and patients with brain metastases (BM) to better explore the molecular basis of BM. Files containing raw data of miRNA expression and proteomic profiles in the manuscript "Combined analysis of micro RNA and proteomic profiles and interactions in patients with primary lung adenocarcinoma and lung adenocarcinoma brain metastases".</p>
Integrated multi-omics analysis of early lung adenocarcinoma links tumor biological features with predicted indolence or aggressiveness
<p>This is a collection of datasets presented in the manuscript "Multi-omics data analysis identifies correlations between tumor biology features and predicted behaviors in early lung adenocarcinoma". This study provides a comprehensive profiling of LUAD indolence and aggressiveness at the biological bulk and single cell levels, as well as at the clinical and radiomics levels. This hypothesis generating study uncovers several potential future research avenues. It also highlights the importance and power of data integration to improve our systemic understanding of LUAD and to help reduce the gap between basic science research and clinical practice.</p>
Multimodal Fusion of Liquid Biopsy and CT Enhances Differential Diagnosis of Early-stage Lung Adenocarcinoma
<p>This research explores the potential of multimodal fusion for the differential diagnosis of early-stage lung adenocarcinoma (LUAD) (tumor sizes < 2 cm). It combines liquid biopsy biomarkers, specifically extracellular vesicle long RNA (evlRNA) and the computed tomography (CT) attributes.</p><p>It includes 4 files:</p><p>1. gene expression matrix : gene expression matrix for all samples (normalized read counts) .</p><p>2. evlRNA Rad features: 6 image features, 17 evlRNA features and labels</p><p>3. differentially expressed genes: Differentially expressed genes in LUAD patients compared with Benign individuals.</p><p>4. raw data: raw data used to for figure and table.</p>
LUX-Lung 7: A Phase IIb Trial of Afatinib(BIBW2992) Versus Gefitinib for the Treatment of 1st Line EGFR Mutation Positive Adenocarcinoma of the Lung
ClinicalTrials.gov study NCT01466660. IPD Sharing: Not stated. Countries: 14. Publications: 3.
Study of the Safety and Activity of Lenvatinib (E7080) in Subjects With KIF5B-RET-Positive Adenocarcinoma of the Lung
ClinicalTrials.gov study NCT01877083. IPD Sharing: Not stated. Countries: 5. Publications: 2.
Sunitinib in Never-Smokers With Lung Adenocarcinoma
ClinicalTrials.gov study NCT01829217. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Erlotinib in Women With Previously Untreated Adenocarcinoma of the Lung
ClinicalTrials.gov study NCT00137839. IPD Sharing: Not stated. Countries: 1. Publications: 4.
Dacomitinib (PF-00299804) As A Single Oral Agent In Selected Patients With Adenocarcinoma Of The Lung
ClinicalTrials.gov study NCT00818441. IPD Sharing: YES. Countries: 5. Publications: 2.
FSRT Combines With Bevacizumab for Multiple Brain Metastases in Lung Adenocarcinoma
ClinicalTrials.gov study NCT07058428. IPD Sharing: NO. Countries: 1. Publications: 19.
A Study of Tarceva (Erlotinib) in First Line in Patients With Locally Advanced or Metastatic Lung Adenocarcinoma With EGFR Mutations
ClinicalTrials.gov study NCT01609543. IPD Sharing: Not stated. Countries: 3. Publications: 1.
A Phase II Trial of Afatinib(BIBW 2992) in Third-line Treatment for Patients With Stage IIIB/IV Adenocarcinoma of the Lung Harbouring Wild-type Epidermal Growth Factor Receptor[EGFR]
ClinicalTrials.gov study NCT01003899. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Nintedanib Plus Docetaxel in Japanese Patients With Adenocarcinoma Subtype Non-small Cell Lung Cancer After Failure of First Line Chemotherapy
ClinicalTrials.gov study NCT02300298. IPD Sharing: NO. Countries: 1. Publications: 1.
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These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.