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239
datasets available to search
ShareScore release 0.9.0
Dataset results
239 results for “lung fibroblasts”
Silver Nanoparticles Alter Cell Viability Ex Vivo and in Vitro and Induce Proinflammatory Effects in Human Lung Fibroblasts
<p>Dataset for data generated and presented in following article by Löfdahl et al in Nanomaterials 2020, 10, 1868. doi:10.3390/nano10091868</p>
Data from: Exposure effects beyond the epithelial barrier: trans-epithelial induction of oxidative stress by diesel exhaust particulates in lung fibroblasts in an organotypic human airway model
<p><i>In vitro</i> bronchial epithelial monoculture models have been pivotal in defining the adverse effects of inhaled toxicant exposures; however, they are only representative of one cellular compartment and may not accurately reflect the effects of exposures on other cell types. Lung fibroblasts exist immediately beneath the bronchial epithelial barrier and play a central role in lung structure and function, as well as disease development and progression. We tested the hypothesis that <i>in vitro</i> exposure of a human bronchial epithelial cell barrier to the model oxidant diesel exhaust particulates caused trans-epithelial oxidative stress in the underlying lung fibroblasts using a human bronchial epithelial cell and lung fibroblast co-culture model. We observed that diesel exhaust particulates caused trans-epithelial oxidative stress in underlying lung fibroblasts as indicated by intracellular accumulation of the reactive oxygen species hydrogen peroxide, oxidation of the cellular antioxidant glutathione, activation of NRF2, and induction of oxidative stress responsive genes. Further, targeted antioxidant treatment of lung fibroblasts partially mitigated the oxidative stress response gene expression in adjacent human bronchial epithelial cells during diesel exhaust particulate exposure. This indicates that exposure induced oxidative stress in the airway extends beyond the bronchial epithelial barrier and that lung fibroblasts are both a target and a mediator of the adverse effects of inhaled chemical exposures despite a lack of direct exposure to the inhaled material. These findings illustrate the value of co-culture models and suggest that trans-epithelial exposure effects should be considered in inhalation toxicology research and testing.</p>
Endogenous hsa-circ_0007113 binds hsa-miR-515-5p to regulate senescence in human embryonic lung fibroblasts
Open the record for dataset details and reuse information.
Data from: Exposure effects beyond the epithelial barrier: trans-epithelial induction of oxidative stress by diesel exhaust particulates in lung fibroblasts in an organotypic human airway model
Open the record for dataset details and reuse information.
Crosstalk between Mast Cells and Lung Fibroblasts Is Modified by Alveolar Extracellular Matrix and Influences Epithelial Migration
<p>Datasets for the data generated and presented in the article: https://doi.org/10.3390/ijms22020506</p>
Lung tumor MHCII immunity depends on in situ antigen presentation by fibroblasts. [CAF]
GEO Series GSE164653. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome analysis of murine lung epithelial cells and fibroblasts derived from bleomycin-injured alveolospheres
GEO Series GSE200297. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
Aberrant DNA methylation in Non Small Cell Lung Cancer associated fibroblasts
GEO Series GSE68851. Homo sapiens. 28 samples. Type: Methylation profiling by genome tiling array.
Histone ChIP-seq from fibroblast of lung (ENCSR915QOL)
GEO Series GSE175324. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
polyA mRNA RNA-seq from fibroblast of lung (ENCSR000CPM)
GEO Series GSE78595. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Impact of miR-199-5p, miR-199a-3p and miR-214-3p overexpression on human lung fibroblasts
GEO Series GSE97824. Homo sapiens. 12 samples. Type: Expression profiling by array.
TGF-β signaling activated by cancer-associated fibroblasts determines the histological signature of lung adenocarcinoma
GEO Series GSE169029. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Age-dependent decline in lung regeneration with loss of clonogenicity and myofibroblastic differentiation of lung fibroblasts
GEO Series GSE27964. Mus musculus. 36 samples. Type: Expression profiling by array.
Next Generation Sequencing of Lung Primary Fibroblast Responding to Eosinophil-Degranulation Products
GEO Series GSE102860. Homo sapiens. 12 samples. Type: Expression profiling by high throughput sequencing.
Differences between fibroblasts derived from normal and IPF lungs
GEO Series GSE185259. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
mRNA expression profiling after Ago2-immunoprecipitation (IP) in unstimulated and TGF-β1-stimulated primary parenchymal lung fibroblasts of two control subjects
GEO Series GSE86183. Homo sapiens. 16 samples. Type: Other.
Next generation sequencing analysis of primary rat lung fibroblast, primary rat lung alveolar type 2 cell and a novel 10-4A rat lung cell line transcriptomes
GEO Series GSE155743. Rattus norvegicus. 11 samples. Type: Expression profiling by high throughput sequencing.
polyA mRNA RNA-seq from fibroblast of lung (ENCSR000COO)
GEO Series GSE78585. Homo sapiens. 2 samples. Type: Expression profiling by high throughput sequencing.
Gene expression in lung fibroblasts of patients with emphysema
GEO Series GSE3510. Homo sapiens. 2 samples. Type: Expression profiling by array.
First characterization of the transcriptome of lung fibroblasts of SSc patients and healthy donors of African ancestry.
GEO Series GSE215841. Homo sapiens. 23 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.