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datasets available to search
ShareScore release 0.7.1
Dataset results
29 results for “lymphocyte proliferation”
Data from: Tungsten blocks murine B lymphocyte differentiation and proliferation through downregulation of IL-7 receptor/Pax5 signaling
Tungsten is an emerging environmental toxicant associated with several pediatric leukemia clusters, although a causal association has not been established. Our previous work demonstrated that tungsten exposure resulted in an accumulation of pre-B cells in the bone marrow, the same cell type that accumulates in pediatric acute lymphoblastic leukemia (ALL). To better understand the relevant molecular mechanisms, we performed RNA sequencing on flow sorted pre-B cells from control and tungsten-exposed mice. Tungsten decreased the expression of multiple genes critical for B cell development, including members of the IL-7R and pre-BCR signaling pathways, such as Jak1, Stat5a, Erb1, Pax5, Syk, and Ikzf3. These results were confirmed in an in vitro model of B cell differentiation, where tungsten arrested differentiation at the pro-B cell stage and inhibited proliferation. These changes were associated with decreased expression of multiple genes in the IL-7R signaling pathway and decreased percentage of IL-7R, phosphorylated STAT5 (pSTAT5) double-positive cells. Supplementation with IL-7 or overexpression of Pax5, the transcription factor downstream of IL-7R, rescued the tungsten-induced differentiation block. Together, these data support the hypothesis that IL-7R/Pax5 signaling axis is critical to tungsten-mediated effects on pre-B cell development. Importantly, many of these molecules are modulated in ALL.
Data from: Tungsten blocks murine B lymphocyte differentiation and proliferation through downregulation of IL-7 receptor/Pax5 signaling
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Chronic lymphocytic leukemia cells are activated and proliferate in response to specific Th cells
GEO Series GSE48268. Homo sapiens. 12 samples. Type: Expression profiling by array.
Rejuvenation of mesenchymal stem cells by human peripheral blood lymphocytes: A dual-mechanism for targeting senescent cell clearance and promoting cell proliferation in a coculture system [RNA-Seq]
GEO Series GSE307002. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Selective expression of the transcription elongation factor Eleven Nineteen Lysine-rich Leukemia 3 (ELL3) in actiavted B lymphocytes drives rapid B cell proliferation
GEO Series GSE102360. Homo sapiens. 2 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Dupilumab inhibits proliferation of malignant lymphocytes in Sezary syndrome and boosts anti-tumor immunity
GEO Series GSE290850. Homo sapiens. 11 samples. Type: Expression profiling by high throughput sequencing.
Dual Relief of T-Lymphocyte Proliferation and Effector Function Underlies Response to PD-1 Blockade in Epithelial Malignancies
GEO Series GSE148162. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
NF-κB-induced expression of T-bet suppresses proliferation of malignant B cells and is associated with good prognosis in chronic lymphocytic leukemia [scATAC-seq]
GEO Series GSE234224. Mus musculus. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
RELB Reprograms Exhausted Tumor-Infiltrating Lymphocytes for Improved Adoptive Cell Therapy [proliferation]
GEO Series GSE303442. Homo sapiens. 14 samples. Type: Other.
NF-κB-induced expression of T-bet suppresses proliferation of malignant B cells and is associated with good prognosis in chronic lymphocytic leukemia [scRNA-seq]
GEO Series GSE234225. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
NF-κB-induced expression of T-bet suppresses proliferation of malignant B cells and is associated with good prognosis in chronic lymphocytic leukemia
GEO Series GSE234226. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
PD-1 expression identifies activated and proliferating chronic lymphocytic leukemia cells and is a potential biomarker that informs response and resistance to BTK inhibitor therapy
GEO Series GSE283045. Homo sapiens. 35 samples. Type: Expression profiling by high throughput sequencing.
MiRNAs Evaluating Lymphocyte Proliferation and Apoptosis as Well as Prognosis of Sepsis
ClinicalTrials.gov study NCT02756559. IPD Sharing: UNDECIDED. Countries: 1. Publications: 0.
Brd4 regulates the homeostasis of CD8+ T-lymphocytes and their proliferation in response to antigen stimulation [RNA-seq]
GEO Series GSE179491. Mus musculus. 4 samples. Type: Expression profiling by high throughput sequencing.
Increased chronic lymphocytic leukemia proliferation upon IgM stimulation is sustained by the upregulation of miR-132 and miR-212
GEO Series GSE49697. Homo sapiens; synthetic construct. 120 samples. Type: Expression profiling by array; Non-coding RNA profiling by array.
Zfx controls BCR-induced proliferation and survival of B lymphocytes
GEO Series GSE13547. Mus musculus. 12 samples. Type: Expression profiling by array.
Brd4 regulates the homeostasis of CD8+ T-lymphocytes and their proliferation in response to antigen stimulation [Cut&Tag]
GEO Series GSE179490. Mus musculus. 2 samples. Type: Other.
An RFX/miR-150 axis regulates proliferation of primary human T lymphocytes
GEO Series GSE161096. Homo sapiens. 12 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Brain antigens stimulate proliferation of T lymphocytes with a pathogenic phenotype in multiple sclerosis patients
GEO Series GSE193260. Homo sapiens. 24 samples. Type: Expression profiling by high throughput sequencing.
Access to follicular dendritic cells is a pivotal step in murine chronic lymphocytic leukemia B cell activation and proliferation
GEO Series GSE60925. Mus musculus. 18 samples. Type: Expression profiling by array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.