Find research datasets worth reusing
Search datasets from major research repositories and use ShareScore to quickly assess how well each record supports discovery, access, and reuse.
34
datasets available to search
ShareScore release 0.9.0
Dataset results
34 results for “mRNA localization”
Dataset associated with: The ERM-1 membrane-binding domain directs erm-1 mRNA localization to the plasma membrane in the C. elegans embryo
<p>mRNA localization and transport are integral in regulating gene expression. In <em>Caenorhabditis</em> <em>elegans'</em> embryos, the maternally inherited mRNA erm-1 (Ezrin/Radixin/Moesin) becomes concentrated in anterior blastomeres. erm-1 mRNA localizes within those blastomeres to the plasma membrane where the essential ERM-1 protein, a membrane-actin linker, is also found. We demonstrate that the localization of erm-1 mRNA to the plasma membrane is translation dependent and requires its encoded N-terminal, membrane-binding (FERM) domain. By perturbing translation through multiple methods, we found that erm-1 mRNA localization at the plasma membrane persisted only if the nascent peptide remained in complex with the translating mRNA. Indeed, re-coding the erm-1 mRNA coding sequence while preserving the encoded amino acid sequence did not disrupt erm-1 mRNA localization, corroborating that the information directing mRNA localization resides within its membrane-binding protein domain. A single-molecule inexpensive fluorescence in situ hybridization screen of 17 genes encoding similar membrane-binding domains identified three plasma membrane-localized mRNAs in the early embryo. Ten additional transcripts showed potential membrane localization later in development. These findings point to a translation-dependent pathway for localization of mRNAs encoding membrane-associated proteins.</p>
Axonal mRNA localization in response to neurotrophin treatment
<p>This file contains the required processed data required to implement the code located at https://github.com/RLuisier/AxonLoc that related to the manuscript Axonal mRNA localization in response to neurotrophin treatment by Luisier et al. 2023.</p>
Dataset associated with: The ERM-1 membrane-binding domain directs erm-1 mRNA localization to the plasma membrane in the C. elegans embryo
Open the record for dataset details and reuse information.
Cross-regulome profiling of RNA polymerases highlights the regulatory role of polymerase III on mRNA transcription by maintaining local chromatin architecture [RNA-seq]
GEO Series GSE217477. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
BRD4 localization to lineage-specific enhancers is associated with a distinct transcription factor repertoire [mRNA-Seq]
GEO Series GSE82289. Homo sapiens. 21 samples. Type: Expression profiling by high throughput sequencing.
Impaired local translation of β-actin mRNA in Ighmbp2-deficient motoneurons: implications for spinal muscular atrophy with respiratory distress (SMARD1)
GEO Series GSE111224. Mus musculus. 6 samples. Type: Expression profiling by high throughput sequencing.
Budding yeast mRNA export and processing factor localization
GEO Series GSE30705. Saccharomyces cerevisiae. 7 samples. Type: Genome binding/occupancy profiling by genome tiling array.
Persistent mRNA localization defects and cell death in ALS neurons caused by transient cellular stress
GEO Series GSE157467. Homo sapiens. 130 samples. Type: Expression profiling by high throughput sequencing; Other.
Altered mRNA transport and local translation in i3Neurons with RNA binding protein knockdown
GEO Series GSE299341. Homo sapiens. 52 samples. Type: Expression profiling by high throughput sequencing.
Comprehensive catalog of dendritically localized mRNA isoforms from sub-cellular sequencing of single mouse neurons
GEO Series GSE115480. Mus musculus. 32 samples. Type: Expression profiling by high throughput sequencing.
Spindle-localized mRNA translation mediated by CPEB1 and CPEB4 controls mitotic progression
GEO Series GSE99810. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Neuronal mitochondria transport Pink1 mRNA via Synaptojanin 2 to support local mitophagy
GEO Series GSE193443. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Transcriptome-wide Regulation of Splicing and mRNA Localization by Muscleblind Proteins
GEO Series GSE39911. Mus musculus; Drosophila melanogaster. 55 samples. Type: Expression profiling by high throughput sequencing.
Local Delivery of mRNA Encoding Cytokines Promotes Antitumor Immunity and Tumor Eradication Across Multiple Preclinical Tumor Models
GEO Series GSE179738. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Cross-regulome profiling of RNA polymerases highlights the regulatory role of polymerase III on mRNA transcription by maintaining local chromatin architecture
GEO Series GSE181701. Mus musculus. 93 samples. Type: Genome binding/occupancy profiling by high throughput sequencing; Other; Expression profiling by high throughput sequencing.
Cross-regulome profiling of RNA polymerases highlights the regulatory role of polymerase III on mRNA transcription by maintaining local chromatin architecture [EU-Seq]
GEO Series GSE217478. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Chemical inhibition of exon junction complex assembly impairs mRNA localization and neural stem cells ciliogenesis
GEO Series GSE286119. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing; Other.
Cross-regulome profiling of RNA polymerases highlights the regulatory role of polymerase III on mRNA transcription by maintaining local chromatin architecture [ATAC-seq]
GEO Series GSE181696. Mus musculus. 8 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Cross-regulome profiling of RNA polymerases highlights the regulatory role of polymerase III on mRNA transcription by maintaining local chromatin architecture [PRO-seq]
GEO Series GSE181699. Mus musculus. 16 samples. Type: Other.
LMKB/MARF1 localizes to mRNA processing bodies, interacts with Ge-1, and regulates IFI44L gene expression
GEO Series GSE55974. Homo sapiens. 6 samples. Type: Expression profiling by array.
ScienceDex guides
Understand access before you commit
These curated guides explain access requirements, typical timelines, costs, and reuse considerations for widely used research datasets.
Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.