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27
datasets available to search
ShareScore release 0.9.0
Dataset results
27 results for “mTORC2”
Data from: Loss of mTORC2 signaling in oligodendrocyte precursor cells delays myelination
Myelin abnormalities are increasingly being recognized as an important component of a number of neurologic developmental disorders. The integration of many signaling pathways and cell types are critical for correct myelinogenesis. The PI3-K and mechanistic target of rapamycin (mTOR) pathways have been found to play key roles. mTOR is found within two distinct complexes, mTORC1 and mTORC2. mTORC1 activity has been shown to play a major role during myelination, while the role of mTORC2 is not yet well understood. To determine the role of mTORC2 signaling in myelinogenesis, we generated a mouse lacking the critical mTORC2 component Rictor in oligodendrocyte precursors (OPCs). Targeted deletion of Rictor in these cells decreases and delays the expression of myelin related proteins and reduces the size of cerebral white matter tracts. This is developmentally manifest as a transient reduction in myelinated axon density and g-ratio. OPC cell number is reduced at birth without detectable change in proliferation with proportional reductions in mature oligodendrocyte number at P15. The total number of oligodendrocytes as well as extent of myelination, does improve over time. Adult conditional knock-out (CKO) animals do not demonstrate a behavioral phenotype likely due in part to preserved axonal conduction velocities. These data support and extend prior studies demonstrating an important but transient contribution of mTORC2 signaling to myelin development.
Data from: Loss of mTORC2 signaling in oligodendrocyte precursor cells delays myelination
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Modulations of mTORC2-GATA3 is by isorhamnetin activates endosomal-lysosomal degradation in J774.1 macrophage-like cell line
GEO Series GSE167010. Mus musculus. 20 samples. Type: Expression profiling by array; Expression profiling by high throughput sequencing.
Next Generation Sequencing and Quantitative Analysis of mRNAs in Caenorhabditis elegans Mutant Animals Exhibiting Impaired Hedgehog, mTORC2, or p38 Signaling
GEO Series GSE268363. Caenorhabditis elegans. 36 samples. Type: Expression profiling by high throughput sequencing.
Quantitative analysis of transcriptomes in control and mTORC2-suppressed glioblastoma cells
GEO Series GSE138475. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Activating Transcription Factor 4 modulated TGFb-induced aggresiveness in triple negative breast cancer vis SMAD2/3/4 and mTORC2 signaling
GEO Series GSE113362. Homo sapiens. 20 samples. Type: Expression profiling by high throughput sequencing.
Bat3 regulates T cell terminal differentiation in an mTORC2-dependent manner
GEO Series GSE168435. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Targeting mTORC2-Dependent AKT/FOXO1/RNF125 Signaling Exploits a Therapeutic Vulnerability in c-MET-Activated and β-catenin-Mutated Hepatocellular Carcinoma
GEO Series GSE314652. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
screen miRNAs specifically regulated by mTORC1 or mTORC2
GEO Series GSE61289. Homo sapiens. 3 samples. Type: Non-coding RNA profiling by array.
Transcriptional profiling of ATP-competitive mTOR inhibitors reveals mTORC1 and mTORC2 specific regulatory networks
GEO Series GSE27784. Mus musculus. 12 samples. Type: Expression profiling by array.
Integrin-α10-dependency defines a novel therapeutic strategy targeting RAC and mTORC2 for metastatic myxofibrosarcoma
GEO Series GSE72545. Homo sapiens. 64 samples. Type: Expression profiling by array.
Data from: Na+ influx via Orai1 inhibits intracellular ATP induced mTORC2 signaling to disrupt CD4 T cell gene expression and differentiation
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Transcriptome changes associated with targeting mTORC2 in lung squamous cell carcinoma
GEO Series GSE269711. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Chaperone dependent coordination of nutrient sensing and energy metabolism by mTORC2
GEO Series GSE93948. Mus musculus. 8 samples. Type: Expression profiling by high throughput sequencing.
Hyperactivation of mTORC1 and mTORC2 by multiple oncogenic events causes addiction to eIF4E-dependent mRNA translation in T-cell leukemia
GEO Series GSE59367. Mus musculus. 6 samples. Type: Genome variation profiling by array.
Targeting mTORC2-Dependent AKT/FOXO1/RNF125 Signaling Exploits a Therapeutic Vulnerability in c-MET-Activated and β-catenin-Mutated Hepatocellular Carcinoma [SNU449]
GEO Series GSE314956. Homo sapiens. 6 samples. Type: Expression profiling by high throughput sequencing.
Critical roles of mTORC1 and mTORC2 kinase signaling and glucose metabolism in follicular helper T cell differentiation
GEO Series GSE85555. Mus musculus. 12 samples. Type: Expression profiling by array.
Inactivation of mTORC2 in macrophages is a signature of colorectal cancer that promotes tumorigenesis.
GEO Series GSE96525. Mus musculus. 7 samples. Type: Expression profiling by array.
Genome-wide maps of chromatin H3K9ac state in control and mTORC2-suppressed glioblastoma cells
GEO Series GSE133117. Homo sapiens. 4 samples. Type: Genome binding/occupancy profiling by high throughput sequencing.
Epigenome analysis of control and mTORC2-suppressed glioblastoma cells
GEO Series GSE235207. Homo sapiens. 4 samples. Type: Methylation profiling by genome tiling array.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.