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61 results for “macrolides”
Data from Mehra et al. (2020-05-29), "Hydroxychloroquine or chloroquine with or without a macrolide for treatment of COVID-19: a multinational registry analysis"
<p>Recent <a href="http://doi.org/dw8t">reports</a> have identified errors and implausible results in the <a href="http://doi.org/ggwzsb">title paper</a>, few of which have been corrected to date. To facilitate analysis, I provide a spreadsheet containing all data from tables in the corrected version (2020-05-29), from both the main text (html) and supporting information (PDF).</p> <p><br> The data is uploaded to this publicly-funded repository with the <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255293/">permission</a> of the copyright holder: <em>"Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories ... with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source."</em> Text and data mining are also <a href="http://web.archive.org/web/20200602210529/https://www.elsevier.com/connect/coronavirus-information-center">permitted</a>: <em>"These articles are also available to download with rights for full text and data mining, re-use and analyses for as long as needed."</em></p>
Associated coordinate and mtz files for "Crystal structure of cytochrome P450 NysL and the structural basis for stereo- and regio- selective oxidation of antifungal macrolides"
<p>Coordinate and mtz files for the associated protein structures reported in "Crystal structure of cytochrome P450 NysL and the structural basis for stereo- and regio- selective oxidation of antifungal macrolides".</p>
Recurrent Campylobacter jejuni infections with in vivo selection of resistance to macrolides and carbapenems – assembly dataset
<p><strong>Dataset</strong></p> <p>This dataset comprises the genome assemblies of the first isolate collected from each clinical case (A1 and B1), together with the respective annotation.</p> <p>File “Cje_metadata.xlsx” contains the genome assembly statistics for each isolate, including the European Nucleotide Archive (ENA) accession numbers, genotyping and antibiotic resistance profiles.</p> <p>The directory “Assemblies/” contains the genome assembly (.fasta and .gbk formats) of each isolate presented in the metadata file.</p> <p> </p> <p><strong>Genome assembly and annotation</strong></p> <p>Reads quality control and improvement, species confirmation (using the 8GB database available at https://ccb.jhu.edu/software/kraken/) and <em>de novo</em> assembly were performed using the INNUca v4.2.2 pipeline (https://github.com/B-UMMI/INNUca). Briefly, after reads’ quality analysis using FastQC v0.11.5 (http://www.bioinformatics.babraham.ac.uk/projects/fastqc/) and cleaning with Trimmomatic v0.38 (http://www.usadellab.org/cms/?page=trimmomatic), genomes were <em>de novo</em> assembled with SPAdes 3.14.0 (http://bioinf.spbau.ru/spades) with a mean depth of coverage above 160x, and subsequently improved using Pilon v1.23. Multi-Locus Sequence Typing (MLST) was performed using mlst v2.18.1 software (https://github.com/tseemann/mlst). Genome annotation was performed with RAST server v2.0 (http://rast.nmpdr.org/).</p> <p>The raw sequence reads of each isolate were deposited at ENA under the study accession numbers PRJEB42628 and PRJNA505131.</p> <p> </p> <p><strong>Funding</strong></p> <p>This work was supported by GenomePT (ref. POCI-01-0145-FEDER-022184) from Fundação para a Ciência e Tecnologia, Portugal.</p>
Macrolide Azithromycin to Prevent Rapid Worsening of Symptoms Associated With Chronic Obstructive Pulmonary Disease
ClinicalTrials.gov study NCT00325897. IPD Sharing: NO. Countries: 1. Publications: 9.
Asthma Clinical Research Network (ACRN) Trial - Macrolides in Asthma (MIA)
ClinicalTrials.gov study NCT00318708. IPD Sharing: Not stated. Countries: 1. Publications: 1.
The Anti-inflammatory Effect of Prophylactic Macrolides on Children With Chronic Lung Disease
ClinicalTrials.gov study NCT02544984. IPD Sharing: Not stated. Countries: 1. Publications: 2.
Comparison of Two Macrolides, Azithromycin and Erythromycin, for Symptomatic Treatment of Gastroparesis
ClinicalTrials.gov study NCT01323582. IPD Sharing: Not stated. Countries: 1. Publications: 13.
Doxycycline vs. Macrolide for MRMP (DOMINO)
ClinicalTrials.gov study NCT07306234. IPD Sharing: YES. Countries: 1. Publications: 13.
Fig. 2 in Conoidecyclics A-C from marine macroalga Turbinaria conoides: Newly described natural macrolides with prospective bioactive properties
Fig. 2. (A1-C1) 1H–1H COSY (bold-face bonds), selected HMBCs (double-barbed arrows), (A2-C2) NOE (colored arrows) correlations of conoidecyclics A-C isolated from T. conoides and (A3-C3) computer-generated models using MM2 force field calculations were displayed.
Fig. 5 in Conoidecyclics A-C from marine macroalga Turbinaria conoides: Newly described natural macrolides with prospective bioactive properties
Fig. 5. (A1-A2) Representative hydrogen binding interactions between conoidecyclic C and the amino acyl residues in the catalytic sites of COX-2; (A3-A4) Representative hydrogen binding interactions between conoidecyclic C and the amino acyl residues in the catalytic sites of 5-LOX; (A5-A6) Representative hydrogen binding interactions between conoidecyclic C and the amino acyl residues in the catalytic sites of PTP-1B; (A7-A8) Representative hydrogen binding interactions between conoidecyclic C and the amino acyl residues in the catalytic sites of ACE as obtained from in silico molecular docking analysis.
Fig. 3 in Conoidecyclics A-C from marine macroalga Turbinaria conoides: Newly described natural macrolides with prospective bioactive properties
Fig. 3. (A1-A2) Representative hydrogen binding interactions between conoidecyclic A and the amino acyl residues in the catalytic sites of COX-2; (A3-A4) Representative hydrogen binding interactions between conoidecyclic A and the amino acyl residues in the catalytic sites of 5-LOX; (A5-A6) Representative hydrogen binding interactions between conoidecyclic A and the amino acyl residues in the catalytic sites of PTP-1B; (A7-A8) Representative hydrogen binding interactions between conoidecyclic A and the amino acyl residues in the catalytic sites of ACE as obtained from in silico molecular docking analysis.
Fig. 1 in Conoidecyclics A-C from marine macroalga Turbinaria conoides: Newly described natural macrolides with prospective bioactive properties
Fig. 1. Structural representations of conoidecyclics A-C purified from the solvent extract of T. conoides. The thallus structure (leaf-like) of T. conoides was illustrated.
Fig. 4 in Conoidecyclics A-C from marine macroalga Turbinaria conoides: Newly described natural macrolides with prospective bioactive properties
Fig. 4. (A1-A2) Representative hydrogen binding interactions between conoidecyclic B and the amino acyl residues in the catalytic sites of COX-2; (A3-A4) Representative hydrogen binding interactions between conoidecyclic B and the amino acyl residues in the catalytic sites of 5-LOX; (A5-A6) Representative hydrogen binding interactions between conoidecyclic B and the amino acyl residues in the catalytic sites of PTP-1B; (A7-A8) Representative hydrogen binding interactions between conoidecyclic B and the amino acyl residues in the catalytic sites of ACE as obtained from in silico molecular docking analysis.
Fig. 6 in Conoidecyclics A-C from marine macroalga Turbinaria conoides: Newly described natural macrolides with prospective bioactive properties
Fig. 6. Kinetic studies of the pharmacologic response with regard to inhibition mode of ACE-I (A–C), PTP-1B (D–F) and 5-LOX (G–I), respectively to the studied conoidecyclics A-C. Representation of Dixon plots for conoidecyclics A-C, for the determination of the inhibition constant Ki. The Ki value was determined from the negative X-axis value at the point of the intersection of the four lines. The data were expressed as the mean reciprocal of initial velocity for triplicates (n = 3) at each substrate concentration. Different concentrations of isolated compounds were used, and the inhibitory potentials were expressed in mM.
Effects of Macrolides on Asthma Control
ClinicalTrials.gov study NCT00852579. IPD Sharing: Not stated. Countries: 1. Publications: 3.
Macrolide Maintenance Therapy in Chronic Obstructive Pulmonary Disease
ClinicalTrials.gov study NCT00985244. IPD Sharing: Not stated. Countries: 1. Publications: 3.
A Trial of Placebo Versus Macrolide for Mycoplasma Pneumoniae Childhood Pneumonia: MYTHIC Study
ClinicalTrials.gov study NCT06325293. IPD Sharing: NO. Countries: 1. Publications: 9.
Effects of Long Term Macrolide Antibiotic Therapy in Patients With COPD
ClinicalTrials.gov study NCT00147667. IPD Sharing: Not stated. Countries: 1. Publications: 1.
Macrolides for KCNJ5 - Mutated Aldosterone-Producing Adenoma (MAPA)
ClinicalTrials.gov study NCT03414918. IPD Sharing: UNDECIDED. Countries: 1. Publications: 5.
Efficacy of Long-Term Low Dose Macrolide Therapy in Preventing Early Recurrence of Nasal Polyps After Endoscopic Sinus Surgery
ClinicalTrials.gov study NCT07316959. IPD Sharing: NO. Countries: 1. Publications: 1.
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International Brain Laboratory public data
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OpenNeuro
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