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ShareScore release 0.9.0
Dataset results
9 results for “mammalian fibroblasts”
Data from: New quantitative approaches reveal the spatial preference of nuclear compartments in mammalian fibroblasts
The nuclei of higher eukaryotic cells display compartmentalization and certain nuclear compartments have been shown to follow a degree of spatial organization. To date, the study of nuclear organization has often involved simple quantitative procedures that struggle with both the irregularity of the nuclear boundary and the problem of handling replicate images. Such studies typically focus on inter-object distance, rather than spatial location within the nucleus. The concern of this paper is the spatial preference of nuclear compartments, for which we have developed statistical tools to quantitatively study and explore nuclear organization. These tools combine replicate images to generate 'aggregate maps' which represent the spatial preferences of nuclear compartments. We present two examples of different compartments in mammalian fibroblasts (WI-38 and MRC-5) that demonstrate new knowledge of spatial preference within the cell nucleus. Specifically, the spatial preference of RNA polymerase II is preserved across normal and immortalized cells, whereas PML nuclear bodies exhibit a change in spatial preference from avoiding the centre in normal cells to exhibiting a preference for the centre in immortalized cells. In addition, we show that SC35 splicing speckles are excluded from the nuclear boundary and localize throughout the nucleoplasm and in the interchromatin space in non-transformed WI-38 cells. This new methodology is thus able to reveal the effect of large-scale perturbation on spatial architecture and preferences that would not be obvious from single cell imaging.
Data from: New quantitative approaches reveal the spatial preference of nuclear compartments in mammalian fibroblasts
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Non-viral Induction of Transgene-free iPSCs from Somatic Fibroblasts of Multiple Mammalian Species [marmoset_single-cell]
GEO Series GSE166076. Callithrix jacchus. 71 samples. Type: Expression profiling by high throughput sequencing.
Non-viral Induction of Transgene-free iPSCs from Somatic Fibroblasts of Multiple Mammalian Species [dog]
GEO Series GSE152489. Canis lupus familiaris. 5 samples. Type: Expression profiling by high throughput sequencing.
Non-viral Induction of Transgene-free iPSCs from Somatic Fibroblasts of Multiple Mammalian Species
GEO Series GSE152493. Callithrix jacchus; Canis lupus familiaris; Sus scrofa; Homo sapiens. 107 samples. Type: Expression profiling by high throughput sequencing.
Non-viral Induction of Transgene-free iPSCs from Somatic Fibroblasts of Multiple Mammalian Species [human]
GEO Series GSE152490. Homo sapiens. 4 samples. Type: Expression profiling by high throughput sequencing.
Non-viral Induction of Transgene-free iPSCs from Somatic Fibroblasts of Multiple Mammalian Species [marmoset]
GEO Series GSE152545. Callithrix jacchus. 23 samples. Type: Expression profiling by high throughput sequencing.
Non-viral Induction of Transgene-free iPSCs from Somatic Fibroblasts of Multiple Mammalian Species [pig]
GEO Series GSE152492. Sus scrofa. 4 samples. Type: Expression profiling by high throughput sequencing.
Mitogen induced-nucleosomal response pathway and transcriptional programming in mammalian fibroblasts
GEO Series GSE183856. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
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DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.