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Dataset results
21 results for “mammalian host”
Dataset of host, habitat and vegetation parameters in relation to gastrointestinal parasite infections of small mammalian hosts in Madagascar
<p>The dataset contains information on the endoparasite infection status of 903 individuals of four small mammal species (<em>Microcebus murinus</em>, <em>M. ravelobensis</em>, <em>Eliurus myoxinus</em>, <em>Rattus rattus</em>) in relation to host-specific (sex, body condition, population density) and habitat-specific factors (degree of habitat fragmentation, fragment size, distance to the edge of the fragment, percentage of edge habitat, vegetation structure).</p>
Supplementary movies for: "The mammalian membrane microenvironment regulates the sequential attachment of bacteria to host cells"
<p><strong>Supplementary Movie 1: Live visualization of bacterial attachment to host cells. </strong></p> <p>Microscopic visualizations of <em>E. coli</em> VHH adhesion to HeLa GFP. Maximum intensity projection of a 1-hour confocal microscopy time-lapse at 0.1 fps accelerated 100x. Overlay of bacteria (red) location of initial contact (circles) and their corresponding tracks (colored lines). Scale bar: 50 µm.</p> <p> </p> <p><strong>Supplementary Movie 2: High-speed visualization of bacterial attachment to host cells upon contact.</strong></p> <p>Close-up on microscopic visualizations of <em>E. coli</em> VHH <em>E. coli</em> adhesion to HeLa GFP. Maximum intensity projection of 5-minutes confocal microscopy time-lapses at 1 fps accelerated 10x. Overlay of bacteria (red) location of initial contact (circles) and their corresponding tracks (colored lines).</p> <p> </p> <p><strong>Supplementary Movie 3: Attachment of <em>E. coli</em> VHH to GFP-coated coverslips. </strong></p> <p><em>E. coli</em> VHH in flow binding to the edge of a GFP-functionalized coverslip used as a substrate for a microfluidic channel. Maximum intensity projection of 5-minutes confocal microscopy time-lapse at 1 fps accelerated 10x. Scale bar: 50 µm.</p> <p> </p> <p><strong>Supplementary Movie 4: HeLa GFP cells actively pull bacteria towards their cell body. </strong></p> <p>Maximum intensity projection of a confocal time-lapse experiment at 0.1 fps accelerated 100x of <em>E. coli</em> VHH (red), HeLa GFP (CD80) (green) and 3 mm/s flow. Scale bar: 10 µm.</p> <p> </p> <p><strong>Supplementary Movie 5: Bacteria sequester GFP upon attachment. </strong></p> <p>Maximum intensity projection of 20-minutes epifluorescence microscopy time-lapse at 1 frame per minutes accelerated 60x. <em>E. coli</em> VHH were added on HeLa GFP under static conditions at an MOI of 200 for a couple of minutes and washed 3 times before imaging. Scale bar: 10 µm.</p> <p> </p> <p><strong>Supplementary Movie 6: Flagella promote unspecific transient binding. </strong></p> <p>Maximum intensity projection of a confocal time-lapse experiment at 6 frames per minutes accelerated 100x of flagellated <em>E. coli</em> VHH (red), HeLa GFP (CD80) (green) and 3 mm/s flow. Scale bar: 10 µm.</p>
Viral zoonotic risk is homogenous among taxonomic orders of mammalian and avian reservoir hosts
<p>Data and code for the paper "Viral zoonotic risk is homogenous among taxonomic orders of mammalian and avian reservoir hosts".</p>
Data from: Context-dependent costs and benefits of tuberculosis resistance traits in a wild mammalian host
Disease acts as a powerful driver of evolution in natural host populations, yet individuals in a population often vary in their susceptibility to infection. Energetic trade-offs between immune and reproductive investment lead to the evolution of distinct life-history strategies, driven by the relative fitness costs and benefits of resisting infection. However, examples quantifying the cost of resistance outside of the laboratory are rare. Here, we observe two distinct forms of resistance to bovine tuberculosis (bTB), an important zoonotic pathogen, in a free-ranging African buffalo (Syncerus caffer) population. We characterize these phenotypes as 'infection resistance', in which hosts delay or prevent infection, and 'proliferation resistance', in which the host limits the spread of lesions caused by the pathogen after infection has occurred. We found weak evidence that infection resistance to bTB may be heritable in this buffalo population (h2=0.10) and comes at the cost of reduced body condition and marginally reduced survival once infected, but also associates with an overall higher reproductive rate. Infection resistant animals thus appear to follow a 'fast' pace of life syndrome, in that they reproduce more quickly but die upon infection. In contrast, proliferation resistance had no apparent costs and was associated with measures of positive host health- such as having a higher body condition and reproductive rate. This study quantifies striking phenotypic variation in pathogen resistance and provides evidence for a link between life history variation and a disease resistance trait in a wild mammalian host population.
Data from: Risk alleles for tuberculosis infection associate with reduced immune reactivity in a wild mammalian host
Integrating biological processes across scales remains a central challenge in disease ecology. Genetic variation drives differences in host immune responses, which, along with environmental factors, generates temporal and spatial infection patterns in natural populations that epidemiologists seek to predict and control. However, genetics and immunology are typically studied in model systems, whereas population-level patterns of infection status and susceptibility are uniquely observable in nature. Despite obvious causal connections, organizational scales from genes to host outcomes to population patterns are rarely linked explicitly. Here we identify two loci near genes involved in macrophage (phagocyte) activation and pathogen degradation that additively increase risk of bovine tuberculosis infection by up to 9-fold in wild African buffalo. Furthermore, we observe genotype-specific variation in IL-12 production indicative of variation in macrophage activation. Here we provide measurable differences in infection resistance at multiple scales by characterizing the genetic and inflammatory variation driving patterns of infection in a wild mammal.
Code from: Costs of parasite generalism revealed by abundance patterns across mammalian hosts
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Data from: Risk alleles for tuberculosis infection associate with reduced immune reactivity in a wild mammalian host
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AAV-mediated Inner ear gene delivery triggers mild host immune responses in the mammalian inner ear
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Stable isotope analysis of ectoparasites as a tool for understanding trophic interactions with mammalian hosts
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Data from: Context-dependent costs and benefits of tuberculosis resistance traits in a wild mammalian host
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Data from: The mammalian complement system as an epitome of host–pathogen genetic conflicts
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Host derivation of Sindbis virus influences mammalian type 1 interferon response to infection
GEO Series GSE234344. Homo sapiens. 9 samples. Type: Expression profiling by high throughput sequencing.
Regulation of Trypanosoma brucei total and polysomal mRNA during development within its mammalian host
GEO Series GSE46388. Trypanosoma brucei brucei. 9 samples. Type: Expression profiling by high throughput sequencing.
Macrophage training to Borrelia burgdorferi governs cardiac inflammation in the mammalian host [RNA-seq]
GEO Series GSE125503. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing.
Toxoplasma and Eimeria co-opt the host cFos expression for intracellular development in mammalian cells
GEO Series GSE157395. Mus musculus. 28 samples. Type: Expression profiling by array.
Ehrlichia chaffeensis Transcriptome in Mammalian and Arthropod Hosts Reveals Differential Gene Expression and Post Transcriptional Regulation
GEO Series GSE29109. Ehrlichia chaffeensis; Ehrlichia chaffeensis str. Arkansas. 3 samples. Type: Expression profiling by array.
Bacteria boost mammalian host NAD metabolism by engaging the deamidated biosynthesis pathway
GEO Series GSE127750. Homo sapiens. 16 samples. Type: Expression profiling by high throughput sequencing.
Individual heterogeneity in ixodid tick infestation and prevalence of Borrelia burgdorferi sensu lato in a northern community of small mammalian hosts
<p>Dataset and scripts for our paper "Individual heterogeneity in ixodid tick infestation and prevalence of <i>Borrelia burgdorferi</i> sensu lato in a northern community of small mammalian hosts" in Oecologia</p>
A Model System for Studying the Transcriptomic and Physiological Changes Associated with Mammalian Host-Adaptation by Leptospira interrogans Serovar Copenhageni
GEO Series GSE53818. Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130. 6 samples. Type: Expression profiling by high throughput sequencing.
Macrophage training to Borrelia burgdorferi governs cardiac inflammation in the mammalian host
GEO Series GSE125516. Mus musculus. 14 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing.
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.