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390 results for “mammary gland”
Dataset of Impact of pre-breeding feeding practices on rabbit mammary gland development at mid-pregnancy
<p>The dataset includes search results used in article “Impact of pre-breeding feeding practices on rabbit mammary gland development at mid-pregnancy” biorXiv, 2022.01.17.476562, ver. 3 peer-reviewed and recommended by Peer Community in Animal Science. <a href="https://doi.org/10.1101/2022.01.17.476562">https://doi.org/10.1101/2022.01.17.476562</a></p> <p> </p> <p>Search Results Description: Please use Figure 1 from paper to trace the data made available and experimental group.</p> <p>The excel “raw data 2022-06-24” file contains the following data</p> <ol> <li>Body weight of each rabbit on a weekly basis</li> <li>Analysis of breeding parameters at mid-pregnancy</li> <li>Histological areas of each mammry tissue measured</li> <li>Optical density values obtained for biochemical leptin concentration determination</li> <li>Optical density values obtained for biochemical triglyceride concentration determination</li> <li>Optical density values obtained for biochemical glucose concentration determination</li> <li>Optical density values obtained for biochemical cholesterol concentration determination</li> <li>RT-qPCR results (Ct) from QuantStudio export for milk protein analysis</li> <li>RT-qPCR results (Ct) from QuantStudio export for lipid metabolism analysisen</li> </ol> <p>“Statistical analysis.doc” contained the description of the statistics used in Excel and the description of the linear mixed model analysis , the reference of the script available by the CRAN project is also include.The R scipt file for using the linear mixed model in R added with the "data-croissance-analysis" file.</p>
Investigating the Effect of Positional Variation on Mid-Lactation Mammary Gland Transcriptomics in Mice Fed Either a Low-Fat or High-Fat Diet
<p>Investigating the Effect of Positional Variation on Mid-Lactation Mammary Gland Transcriptomics in Mice Fed Either a Low-Fat or High-Fat Diet.</p>
Dataset for "Surface tension induced budding drives alveologenesis in mammary gland organoids"
<p>Live-cell imaging of organoids from primary human mammary epithelial cells, including responses to laser ablation experiments and data analysis scripts.</p> <p>Please see README file for details.</p>
Effects of Atractylodes Macrocephala Rhizoma polysaccharide on intestinal microbiota composition in rats with mammary gland hyperplasia
<p class="MsoNormal"><strong><span>Background</span></strong><span>: In recent years, Mammary gland hyperplasia (MGH) </span><span>has been</span><span> considered to be one of the diseases caused by endocrine disorders. It has been shown that diseases caused by endocrine disorders can be treated by regulating intestinal microbial. As a commonly used medicine in clinical practice, <em>Atractylodes </em></span><em><span>M</span></em><em><span>acrocephala Rhizoma</span></em><span> has good functions in regulating intestinal homeostasis. Therefore, this paper studied the effect of <em>Atractylodes </em></span><em><span>M</span></em><em><span>acrocephala Rhizoma</span></em><span> polysaccharide (AMP), on the intestinal flora of MGH rats, providing a new idea for polysaccharide treatment of MGH.</span></p> <p class="MsoNormal"><strong><span>Materials and methods</span></strong><span>: </span><span>Eighteen</span><span> female SD rats were selected and randomly divided into three groups, blank control group (Con), model control group (Mod) and AMP group, six rats in each group. MGH rat models were established by estradiol-progesterone combination and treated with AMP gastric infusion. The levels of E<sub>2</sub>, P and PRL in the serum of rats were measured, the intestinal contents were collected, and 16s rRNA high-throughput sequencing technology was used to analyze the changes of intestinal flora in the MGH rats.</span></p> <p class="MsoNormal"><strong><span>Results</span></strong><span>: AMP has good therapeutic effects on MGH rats, decreasing estradiol (E<sub>2</sub>) and prolactin (PRL) levels and increasing progesterone (P) levels, at the same time, it can regulate the abundance and diversity of intestinal flora of MGH rats, improve the disorder of intestinal flora caused by MGH </span><span>and </span><span>change the community structure, increase the abundance of beneficial flora and decrease the abundance of pathogenic flora.</span></p> <p class="MsoNormal"><strong><span>Conclusion</span></strong><span>: AMP can improve the intestinal microbiological environment of MGH rats, maintain the microecological balance of intestinal microbial</span><span>, and improve MGH symptoms</span><span>.</span></p>
Construction of microneedle of Atractylodes macrocephala aqueous extract and effect on mammary gland hyperplasia based on intestinal flora
<p><strong><span>Background</span></strong><span>: </span><span>A </span><span>microneedle</span><span> patch loaded with <em>Atractylodes macrocephala</em> water extract was prepared for the treatment of mammary gland hyperplasia to explore the relationship between MGH and intestinal flora. </span></p> <p><strong><span>Materials and methods</span></strong><span>: </span><span>Preparation of the microneedle patch by micromolding method, the prescription of the microneedle was optimized by the Box-Behnken Design response surface test, and the micro-morphology, penetration, toughness, and brittleness were investigated. <em>In vitro</em> release of drug-loaded microneedles was measured by diffusion cell method. The rat model of mammary gland hyperplasia was prepared by the combination of estradiol benzoate-progesterone, and the microneedle patch of <em>Atractylodes macrocephala</em> aqueous extract was used for intervention treatment. The change of levels in E<sub>2</sub>, P, and PRL in rat serum was determined. The intestinal contents of rats were collected and the changes in intestinal flora in MGH rats were analyzed by 16s rRNA high-throughput sequencing. </span></p> <p><strong><span>Results</span></strong><span>: </span><span>The optimized microneedle formula is a PVA concentration of 6.0%, HA concentration of 15.5%, and PVPK30 concentration of 16.0%. The prepared microneedle tip loaded with <em>Atractylodes macrocephala</em> aqueous extract has complete, sharp, and no bubbles and the needle rate of the microneedle array is in the range of 95%~100%. The bending rate of the microneedle is about 12.7%, and it has good flexibility, and the microneedle can puncture 4 layers of Parafilm</span><span>Ⓡ</span><span> membrane smoothly, and the puncture rate is more than 96%. The <em>in vitro</em> release of the microneedle was characterized by rapid release. The results of animal experiments showed that <em>Atractylodes macrocephala</em> aqueous extract microneedle patch could significantly reduce the E<sub>2</sub> level, significantly reduce the PRL level, and significantly increase the P level. At the same time, it can regulate the abundance and diversity of intestinal flora in MGH rats, improve the intestinal flora disorder caused by mammary gland hyperplasia, and balance the community structure. </span></p> <p><strong><span>Conclusion</span></strong><span>: </span><span>The prepared microneedle containing <em>Atractylodes macrocephala</em> aqueous extract has good toughness and brittle strength, can penetrate the skin and enter the dermis, and effectively deliver drugs to play a role in the treatment of mammary gland hyperplasia.</span></p>
Construction of microneedle of Atractylodes macrocephala aqueous extract and effect on mammary gland hyperplasia based on intestinal flora
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Effects of Atractylodes Macrocephala Rhizoma polysaccharide on intestinal microbiota composition in rats with mammary gland hyperplasia
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Accelerating Whole-Sample Polarization-Resolved Second Harmonic Generation imaging in Mammary Gland Tissue via Generative Adversarial Networks
<p>Authors:</p> <p>Arash Aghigh, Jysiane Cardot, Melika Saadat Mohammadi, Gaëtan Jargot, Heide Ibrahim, Isabelle Plante, François Légaré</p> <p>Affiliations:</p> <p> 1. Centre Énergie Matériaux Télécommunications, Institut National de la Recherche Scientifique, Varennes, Québec, Canada.<br> 2. Centre Armand-Frappier Santé Biotechnologie, Institut National de la Recherche Scientifique, Laval, Québec, Canada.</p> <p>Corresponding Author:</p> <p>Arash Aghigh, arash.aghigh@inrs.ca</p> <p>Description:</p> <p>This dataset accompanies the research on improving whole-sample Polarization-Resolved Second Harmonic Generation (P-SHG) imaging in mammary gland tissue using Enhanced Super-Resolution Generative Adversarial Networks (ESRGAN). The novel approach significantly reduces imaging time while maintaining high image quality and analytical accuracy, demonstrating a reduction in imaging time by more than 95%. This method also minimizes laser-induced photodamage, lowers costs of optical components, and increases the accessibility and applicability of P-SHG imaging in various fields.</p> <p>Keywords:</p> <p>Polarization-Resolved Second Harmonic Generation, P-SHG, Generative Adversarial Networks, GAN, ESRGAN, Mammary Gland Imaging, Super-Resolution, Image Upscaling, Deep Learning, Biomedical Imaging</p> <p>Funding Information:</p> <p> • Canada Foundation for Innovation<br> • Fonds de recherche du Québec–Nature et technologies<br> • Natural Sciences and Engineering Research Council of Canada<br> • New Frontiers Research Fund<br> • NSERC CREATE program (scholarship for Arash Aghigh)</p> <p>Related Identifiers:</p> <p> • GitHub repository for ChaiNNer program: https://github.com/chaiNNer-org/chaiNNer<br> • Download links for models used: https://openmodeldb.info</p> <p>Additional Information:</p> <p>Animal studies were conducted according to the procedures provided by the Canadian Council on Animal Care. The protocol (2005-02) was reviewed and approved by the Institutional Committee for Animal Protection of the Laboratoire National de Biologie Expérimentale (LNBE), the animal facilities based at the Institut National de Recherche Scientifique (INRS).</p>
Supplementary data to publication "Cellular detection of the chemokine receptor CXCR4 in bovine mammary glands and its distribution and regulation on bovine leukocytes"
<p>Supplementary data to publication "Cellular detection of the chemokine receptor CXCR4 in bovine mammary glands and its distribution and regulation on bovine leukocytes" in Journal of Dairy Science; https://doi.org/10.3168/jds.2021-20799</p>
Data from: Digital gene expression analyses of mammary glands from meat ewes naturally infected with clinical mastitis
Clinical mastitis in sheep has gravely restrained production performance for a long time. Knowledge of mechanisms of its pathogenesis and resistance in meat sheep mammary gland with clinical mastitis are not yet understood, especially for clinical mastitis caused by natural infection. In this work, RNA-seq was firstly used to screen differentially expressed genes (DEGs) in clinical mastitic mammary tissues (CMMTs) as compared to healthy mammary tissues (HMTs) from meat sheep flocks. We identified 420 DEGs including 316 up-regulated and 104 down-regulated genes in CMMTs. Gene Ontology annotation revealed these DEGs were mainly engaged in immune response, inflammation response, etc. Pathway enrichment showed they were primarily enriched in pathways relevant to inflammation, immune response and metabolism. Alternative splicing analysis showed most common differential splicing genes (DSGs) in CMMTs and HMTs were implicated in immune response. Immunostaining for two immune response-related proteins encoded by DEGs were mainly observed in mammary epithelium between CMMTs and HMTs, and their positive signals were more intensive in CMMTs. These findings provide experimental basis and reference for further researching the molecular genetic mechanisms particularly immune defense mechanisms of mammary gland in clinical ovine mastitis.
Data from: Digital gene expression analyses of mammary glands from meat ewes naturally infected with clinical mastitis
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Exposure to ionizing radiation induced persistent gene expression changes in mouse mammary gland
Six to eight week old female C57BL/6J mice were exposed to 2 Gy of whole body xce xb3 radiation and mammary glands were surgically removed 2-month after radiation. RNA was isolated and microarray hybridization performed for gene expression analysis. 5 samples were analyzed: 2 controls at 2 months 1 2 Gy at 2 months and 2 7 Gy at 2 months
scRNA-seq, snATAC-seq, and spatial transcriptomics analysis of mammary glands of aged female mice
GEO Series GSE216542. Mus musculus. 22 samples. Type: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other.
Bptf maintains chromatin accessibility and the self-renewal capacity of mammary gland stem cells [RNA-Seq]
GEO Series GSE98003. Mus musculus. 10 samples. Type: Expression profiling by high throughput sequencing.
Gene expression profiles for hyperglycemia induced tumors and mammary glands compared to those in euglycemia
GEO Series GSE40361. Mus musculus. 12 samples. Type: Expression profiling by array.
Characterization and comparison of lactating mouse and bovine mammary gland miRNomes
GEO Series GSE53511. Bos taurus; Mus musculus. 6 samples. Type: Non-coding RNA profiling by high throughput sequencing.
Characterization of estrogen, progesterone and the endocrine-disrupting chemical-induced mouse mammary gland reorganization via single-cell RNA-sequencing
GEO Series GSE149949. Mus musculus. 5 samples. Type: Expression profiling by high throughput sequencing.
Mammary gland tumor immunoinfiltrate analysis
GEO Series GSE150921. Mus musculus. 2 samples. Type: Expression profiling by high throughput sequencing.
Single cell RNA-seq of 346 epithelial cells from the mammary glands of pre-pubescent, pubescent and adult mice
GEO Series GSE95434. Mus musculus. 346 samples. Type: Expression profiling by high throughput sequencing.
TRPS1 maintains luminal progenitors in the mammary gland by repressing SRF/MRTF activity [02_citeseq_shTRPS1_mmg]
GEO Series GSE243508. Mus musculus. 12 samples. Type: Expression profiling by high throughput sequencing.
ScienceDex guides
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Allen Brain Atlas
Allen Brain Atlas is an Allen Institute collection of brain map atlases, datasets, APIs, and analysis tools covering mouse, human, and non-human primate brain resources.
Annotated Behaviour and Observability Dataset (ABODe)
ABODe is a University of Edinburgh DataShare dataset for behavior classification in group-housed mice using home-cage video, identities, bounding boxes, ground-plate positions, and annotator labels.
DANDI Archive for NWB datasets
DANDI is a BRAIN Initiative archive for publishing and sharing neurophysiology data, including electrophysiology, optophysiology, and behavioral data packaged as NWB and related standards.
International Brain Laboratory public data
The International Brain Laboratory public data releases expose standardized mouse decision-making experiments, including Neuropixels recordings, widefield calcium imaging, behavior, and session metadata accessed through the ONE API.
OpenNeuro
OpenNeuro is a free, open platform for sharing neuroimaging datasets, with public search, dataset pages, and download paths for web, S3, DataLad, and the OpenNeuro CLI.